D-Index & Metrics Best Publications

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 56 Citations 10,149 164 World Ranking 7106 National Ranking 143

Overview

What is she best known for?

The fields of study she is best known for:

  • Gene
  • Internal medicine
  • Cancer

Her primary areas of study are Cell biology, Cartilage, Osteoblast, Bone morphogenetic protein and Cellular differentiation. Her Cell biology study combines topics from a wide range of disciplines, such as Internal medicine, Biochemistry and Endocrinology. The Chondrocyte research Di Chen does as part of her general Cartilage study is frequently linked to other disciplines of science, such as Aggrecan, therefore creating a link between diverse domains of science.

The concepts of her Osteoblast study are interwoven with issues in Bone morphogenetic protein 7, Bone morphogenetic protein 2 and Proteasome. The study incorporates disciplines such as Molecular biology and Noggin in addition to Bone morphogenetic protein 2. The various areas that Di Chen examines in her Cellular differentiation study include Mesenchymal stem cell and BMP signaling pathway.

Her most cited work include:

  • Stimulation of bone formation in vitro and in rodents by statins. (1470 citations)
  • MicroRNA-204 regulates Runx2 protein expression and mesenchymal progenitor cell differentiation. (437 citations)
  • Activation of β-Catenin Signaling in Articular Chondrocytes Leads to Osteoarthritis-Like Phenotype in Adult β-Catenin Conditional Activation Mice (338 citations)

What are the main themes of her work throughout her whole career to date?

Her primary scientific interests are in Cell biology, Cartilage, Internal medicine, Chondrocyte and Endocrinology. Her Cell biology study integrates concerns from other disciplines, such as Cellular differentiation and Osteoblast. Her study in Osteoblast is interdisciplinary in nature, drawing from both Osteoclast, Ubiquitin ligase, Bone morphogenetic protein 2 and Cancer research.

Her work deals with themes such as Immunohistochemistry, Pathology, Bioinformatics and Conditional gene knockout, which intersect with Cartilage. Her research investigates the link between Chondrocyte and topics such as Molecular biology that cross with problems in Transcription factor and Bone morphogenetic protein 4. Her Endocrinology research is multidisciplinary, relying on both Downregulation and upregulation, Bone morphogenetic protein 7 and Transgene.

She most often published in these fields:

  • Cell biology (45.21%)
  • Cartilage (29.89%)
  • Internal medicine (22.99%)

What were the highlights of her more recent work (between 2018-2021)?

  • Cell biology (45.21%)
  • Cartilage (29.89%)
  • Pathogenesis (6.51%)

In recent papers she was focusing on the following fields of study:

Di Chen spends much of her time researching Cell biology, Cartilage, Pathogenesis, Internal medicine and Pathology. Her Cell biology research is multidisciplinary, incorporating elements of Osteoclast and Osteoblast. She combines subjects such as Bone growth and Bone marrow with her study of Osteoblast.

Her Cartilage research integrates issues from Immunohistochemistry, Condyle, Arthritis, MMP3 and Stem cell. She interconnects Lumbar and Endocrinology in the investigation of issues within Internal medicine. Her studies in Pathology integrate themes in fields like Phenotype and Synovitis.

Between 2018 and 2021, her most popular works were:

  • Ankylosing spondylitis: etiology, pathogenesis, and treatments (40 citations)
  • Excessive mechanical loading promotes osteoarthritis through the gremlin-1-NF-κB pathway. (39 citations)
  • The microRNAs miR-204 and miR-211 maintain joint homeostasis and protect against osteoarthritis progression. (36 citations)

In her most recent research, the most cited papers focused on:

  • Gene
  • Internal medicine
  • Cancer

Her main research concerns Cell biology, Cartilage, Downregulation and upregulation, Endocrinology and Internal medicine. Her Cell biology research is multidisciplinary, relying on both Bone morphogenetic protein, RUNX2, Tissue homeostasis and Intervertebral disc. Her work deals with themes such as NFKB1, Transcription factor and NF-κB, Signal transduction, which intersect with Cartilage.

The various areas that Di Chen examines in her Downregulation and upregulation study include Immunohistochemistry, CRISPR, Bioinformatics, Nerve growth factor and Histology. Her Endocrinology study frequently links to adjacent areas such as MMP3. When carried out as part of a general Internal medicine research project, her work on Adipocyte, Matrix metalloproteinase and Adipose tissue is frequently linked to work in Leptin, therefore connecting diverse disciplines of study.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Stimulation of bone formation in vitro and in rodents by statins.

G. Mundy;R. Garrett;S. Harris;J. Chan.
Science (1999)

2396 Citations

MicroRNA-204 regulates Runx2 protein expression and mesenchymal progenitor cell differentiation.

Jian Huang;Lan Zhao;Lianping Xing;Di Chen.
Stem Cells (2009)

598 Citations

Activation of β-Catenin Signaling in Articular Chondrocytes Leads to Osteoarthritis-Like Phenotype in Adult β-Catenin Conditional Activation Mice

Mei Zhu;Dezhi Tang;Dezhi Tang;Qiuqian Wu;Suyang Hao.
Journal of Bone and Mineral Research (2009)

468 Citations

Osteoarthritis: toward a comprehensive understanding of pathological mechanism.

Di Chen;Jie Shen;Weiwei Zhao;Weiwei Zhao;Tingyu Wang.
Bone research (2017)

404 Citations

The BMP signaling and in vivo bone formation

Xu Cao;Di Chen.
Gene (2005)

367 Citations

Smad5 and DPC4 Are Key Molecules in Mediating BMP-2-induced Osteoblastic Differentiation of the Pluripotent Mesenchymal Precursor Cell Line C2C12

Riko Nishimura;Riko Nishimura;Yoichi Kato;Di Chen;Stephen E. Harris.
Journal of Biological Chemistry (1998)

364 Citations

Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro

I.R. Garrett;D. Chen;G. Gutierrez;M. Zhao.
Journal of Clinical Investigation (2003)

346 Citations

E3 Ubiquitin Ligase Smurf1 Mediates Core-binding Factor α1/Runx2 Degradation and Plays A Specific Role in Osteoblast Differentiation

Ming Zhao;Mei Qiao;Babatunde O. Oyajobi;Gregory R. Mundy.
Journal of Biological Chemistry (2003)

326 Citations

BONE MORPHOGENETIC PROTEIN 2 (BMP-2) ENHANCES BMP-3, BMP-4, AND BONE CELL DIFFERENTIATION MARKER GENE EXPRESSION DURING THE INDUCTION OF MINERALIZED BONE MATRIX FORMATION IN CULTURES OF FETAL RAT CALVARIAL OSTEOBLASTS

D. Chen;M. A. Harris;G. Rossini;C. R. Dunstan.
Calcified Tissue International (1997)

307 Citations

MMP13 is a critical target gene during the progression of osteoarthritis

Meina Wang;Meina Wang;Erik R Sampson;Hongting Jin;Hongting Jin;Jia Li;Jia Li.
Arthritis Research & Therapy (2013)

296 Citations

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