World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
85
Citations
25668
World Ranking
3156
National Ranking
86

Overview

Di Chen is affiliated with the Chinese Academy of Sciences in China and has a research portfolio primarily focused on Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans several key subfields including Molecular Biology, Rheumatology, Genetics, Oncology, and Surgery.

Their research addresses a range of biomedical topics, notably in osteoarthritis treatment and mechanisms, bone metabolism and diseases, and spine and intervertebral disc pathology. Other significant subject areas include cell adhesion molecules research, glioma diagnosis and treatment, musculoskeletal pain and rehabilitation, as well as inflammatory mediators and NSAID effects.

Di Chen has contributed to multiple recent scientific publications, with selected papers including:

  • Metformin limits osteoarthritis development and progression through activation of AMPK signalling, 2020, Annals of the Rheumatic Diseases
  • Modifiable risk factors associated with cardiovascular disease and mortality in China: a PURE substudy, 2022, European Heart Journal
  • Risk of metabolic abnormalities in osteoarthritis: a new perspective to understand its pathological mechanisms, 2023, Bone Research
  • Osteoarthritis Pain, 2022, International Journal of Molecular Sciences
  • Morroniside attenuates apoptosis and pyroptosis of chondrocytes and ameliorates osteoarthritic development by inhibiting NF-κB signaling, 2020, Journal of Ethnopharmacology

The scientist frequently publishes in well-regarded journals such as Bone Research, Journal of Orthopaedic Translation, Nature Communications, Theranostics, and Journal of Neurorestoratology. Their publication record shows repeated contributions, for example, seven papers in Bone Research and multiple papers in other venues.

Throughout their career, Di Chen has collaborated extensively with other researchers, including Guozhi Xiao, Huiling Cao, Hongting Jin, Xiaohao Wu, and Yumei Lai, with whom they have coauthored several papers.

Best Publications

  • Osteoarthritis: toward a comprehensive understanding of pathological mechanism.

    Di Chen;Jie Shen;Weiwei Zhao;Tingyu Wang

  • Activation of β-Catenin Signaling in Articular Chondrocytes Leads to Osteoarthritis-Like Phenotype in Adult β-Catenin Conditional Activation Mice

    Mei Zhu;Dezhi Tang;Dezhi Tang;Qiuqian Wu;Suyang Hao

  • MMP13 is a critical target gene during the progression of osteoarthritis

    Meina Wang;Meina Wang;Erik R Sampson;Hongting Jin;Hongting Jin;Jia Li;Jia Li

  • Osteoarthritis Pathogenesis: A Review of Molecular Mechanisms

    Bingjiang Xia;Di Chen;Di Chen;Jushi Zhang;Songfeng Hu

  • The BMP signaling and in vivo bone formation

    Xu Cao;Di Chen

  • Smad5 and DPC4 Are Key Molecules in Mediating BMP-2-induced Osteoblastic Differentiation of the Pluripotent Mesenchymal Precursor Cell Line C2C12

    Riko Nishimura;Yoichi Kato;Di Chen;Stephen E. Harris

  • Ankylosing spondylitis: etiology, pathogenesis, and treatments

    Wei Zhu;Xuxia He;Kaiyuan Cheng;Linjie Zhang

  • E3 Ubiquitin Ligase Smurf1 Mediates Core-binding Factor α1/Runx2 Degradation and Plays A Specific Role in Osteoblast Differentiation

    Ming Zhao;Mei Qiao;Babatunde O. Oyajobi;Gregory R. Mundy

  • Intestinal epithelial vitamin D receptor deletion leads to defective autophagy in colitis

    Shaoping Wu;Yong Guo Zhang;Rong Lu;Yinglin Xia

  • Tumor Necrosis Factor Promotes Runx2 Degradation through Up-regulation of Smurf1 and Smurf2 in Osteoblasts

    Hiroyuki Kaneki;Ruolin Guo;Di Chen;Zhenqiang Yao

  • Wnt/β-catenin signaling activates bone morphogenetic protein 2 expression in osteoblasts

    Rongrong Zhang;Babatunde O. Oyajobi;Stephen E. Harris;Di Chen

  • Inhibition of β-Catenin Signaling in Articular Chondrocytes Results in Articular Cartilage Destruction

    Mei Zhu;Mo Chen;Michael Zuscik;Qiuqian Wu

  • Regulation of chondrogenesis and chondrocyte differentiation by stress

    Michael J. Zuscik;Matthew J Hilton;Xinping Zhang;Di Chen

  • MEPE has the properties of an osteoblastic phosphatonin and minhibin

    P.S.N Rowe;Y Kumagai;G Gutierrez;I.R Garrett

  • BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development

    Bing Shu;Ming Zhang;Rong Xie;Meina Wang

  • Dual effects of macrophage inflammatory protein-1α on osteolysis and tumor burden in the murine 5TGM1 model of myeloma bone disease

    Babatunde O. Oyajobi;Giovanni Franchin;Paul J. Williams;Donna Pulkrabek

  • Smurf1 Inhibits Osteoblast Differentiation and Bone Formation in Vitro and in Vivo

    Ming Zhao;Mei Qiao;Stephen E. Harris;Babatunde O. Oyajobi

  • TGF-β signaling and the development of osteoarthritis.

    Jie Shen;Shan Li;Di Chen

  • Recent progress in understanding molecular mechanisms of cartilage degeneration during osteoarthritis

    Meina Wang;Jie Shen;Hongting Jin;Hongting Jin;Hee Jeong Im

  • Excessive mechanical loading promotes osteoarthritis through the gremlin-1-NF-κB pathway.

    Song Ho Chang;Daisuke Mori;Hiroshi Kobayashi;Yoshifumi Mori;Yoshifumi Mori

Frequent Co-Authors

Guozhi Xiao
Guozhi Xiao Southern University of Science and Technology
Regis J. O'Keefe
Regis J. O'Keefe Washington University in St. Louis
Hee-Jeong Im
Hee-Jeong Im University of Illinois at Chicago
Michael J. Zuscik
Michael J. Zuscik University of Rochester
Gregory R. Mundy
Gregory R. Mundy Vanderbilt University
Howard S. An
Howard S. An Rush University Medical Center
Brendan F. Boyce
Brendan F. Boyce University of Rochester Medical Center
Edward M. Schwarz
Edward M. Schwarz University of Rochester Medical Center
Hicham Drissi
Hicham Drissi Emory University
Chu-Xia Deng
Chu-Xia Deng University of Macau

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Best Scientists Citing Di Chen

Trending Scientists

Recently Published Articles