World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
48
Citations
8089
World Ranking
18422
National Ranking
7520

Overview

Hicham Drissi is affiliated with Emory University in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on molecular biology, rheumatology, surgery, genetics, and immunology as significant subfields.

The main topics of Drissi's work include osteoarthritis treatment and mechanisms, bone metabolism and diseases, mesenchymal stem cell research, spine and intervertebral disc pathology, knee injuries and reconstruction techniques, TGF-β signaling in diseases, and bone health and treatments.

Drissi has published extensively, with recent papers including:

  • Cell-based versus corticosteroid injections for knee pain in osteoarthritis: a randomized phase 3 trial, 2023, Nature Medicine
  • Single-cell RNA-seq identifies unique transcriptional landscapes of human nucleus pulposus and annulus fibrosus cells, 2020, Scientific Reports
  • Bifidobacterium adolescentis supplementation attenuates fracture-induced systemic sequelae, 2020, Biomedicine & Pharmacotherapy
  • Current perspectives on the multiple roles of osteoclasts: Mechanisms of osteoclast-osteoblast communication and potential clinical implications, 2024, eLife
  • Sexual Dimorphism in Differentiating Osteoclast Precursors Demonstrates Enhanced Inflammatory Pathway Activation in Female Cells, 2020, Journal of Bone and Mineral Research

Frequent coauthors include Nazir M. Khan, Martha Elena Díaz-Hernández, Joseph L. Roberts, Pallavi Bhattaram, and Jarred Kaiser.

The scientist has published regularly in venues such as bioRxiv (Cold Spring Harbor Laboratory), eLife, Journal of Orthopaedic Research®, Bone, and JOR Spine.

Best Publications

  • Runx2-mediated regulation of the zinc finger Osterix/Sp7 gene.

    Yasuhiko Nishio;Yufeng Dong;Mark Paris;Regis J. O'Keefe

  • Transcriptional autoregulation of the bone related CBFA1/RUNX2 gene.

    Hicham Drissi;Quyen Luc;A. Rauf Shakoori;Susana Chuva De Sousa Lopes

  • Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor.

    Yu-Feng Dong;Do Y. Soung;Edward M. Schwarz;Regis J. O'Keefe

  • 1,25-(OH)2-Vitamin D3 Suppresses the Bone-Related Runx2/Cbfa1 Gene Promoter

    Hicham Drissi;Arlyssa Pouliot;Christian Koolloos;Janet L Stein

  • Phenotype discovery by gene expression profiling: mapping of biological processes linked to BMP-2-mediated osteoblast differentiation.

    Eva Balint;David S. Lapointe;Hicham Drissi;Caroline M. J. van der Meijden

  • Reduced COX-2 expression in aged mice is associated with impaired fracture healing.

    Amish A Naik;Chao Xie;Michael J. Zuscik;Paul Kingsley

  • Smad3‐Deficient Chondrocytes Have Enhanced BMP Signaling and Accelerated Differentiation

    Tian Fang Li;Michael Darowish;Michael J. Zuscik;Di Chen

  • Quantitative mouse model of implant-associated osteomyelitis and the kinetics of microbial growth, osteolysis, and humoral immunity.

    Dan Li;Kirill Gromov;Kirill Gromov;Kjeld Søballe;J. Edward Puzas

  • Primary murine limb bud mesenchymal cells in long-term culture complete chondrocyte differentiation: TGF-β delays hypertrophy and PGE2 inhibits terminal differentiation

    Xinping Zhang;Navid Ziran;J.Jeffery Goater;Edward M Schwarz

  • Runx1/AML1/Cbfa2 mediates onset of mesenchymal cell differentiation toward chondrogenesis.

    YongJun Wang;Ruth M Belflower;Yu-Feng Dong;Edward M Schwarz

  • Osterix/Sp7 regulates mesenchymal stem cell mediated endochondral ossification.

    Lee A. Kaback;Do Y. Soung;Amish Naik;Nathan Smith

  • Transcriptional regulation of chondrocyte maturation: potential involvement of transcription factors in OA pathogenesis.

    Hicham Drissi;Michael Zuscik;Randy Rosier;Regis O’Keefe

  • Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice.

    Qiuqian Wu;Kyung-Ok Kim;Erik R. Sampson;Di Chen

  • Cyclin D1-Cdk4 Induce Runx2 Ubiquitination and Degradation

    Run Shen;Xiumei Wang;Hicham Drissi;Fang Liu

  • Murine and chicken chondrocytes regulate osteoclastogenesis by producing RANKL in response to BMP2

    Michihiko Usui;Lianping Xing;Hicham Drissi;Michael Zuscik

  • Runx1/AML1 hematopoietic transcription factor contributes to skeletal development in vivo.

    Jane B. Lian;Eva Balint;Amjad Javed;Hicham Drissi

  • Parathyroid hormone-related peptide (PTHrP) inhibits Runx2 expression through the PKA signaling pathway

    Tian-Fang Li;Yufeng Dong;Andreia M Ionescu;Randy N Rosier

  • Transcription factors RUNX1/AML1 and RUNX2/Cbfa1 dynamically associate with stationary subnuclear domains

    Kimberly Stacy Harrington;Amjad Javed;Hicham Drissi;Sandra Marie McNeil

  • Overexpression of MiR-335-5p Promotes Bone Formation and Regeneration in Mice†

    Lan Zhang;Yin Tang;Xiaofang Zhu;Tianchi Tu

  • Roles of SATB2 in Osteogenic Differentiation and Bone Regeneration

    Jin Zhang;Qisheng Tu;Rudolf Grosschedl;Min Seok Kim

Frequent Co-Authors

Regis J. O'Keefe
Regis J. O'Keefe Washington University in St. Louis
Edward M. Schwarz
Edward M. Schwarz University of Rochester Medical Center
Michael J. Zuscik
Michael J. Zuscik University of Rochester
Di Chen
Di Chen Chinese Academy of Sciences
Le T. Duong
Le T. Duong MSD (United States)
Andrés J. García
Andrés J. García Georgia Institute of Technology
M. Neale Weitzmann
M. Neale Weitzmann Emory University
Frank Barry
Frank Barry University of Galway
Florence Apparailly
Florence Apparailly University of Montpellier
Greg Gibson
Greg Gibson Georgia Institute of Technology

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