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Medicine

D-Index
102
Citations
31923
World Ranking
7754
National Ranking
4040

Overview

Regis J. O'Keefe is affiliated with Washington University in St. Louis in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a particular focus on Surgery, Molecular Biology, Rheumatology, Cancer Research, and Orthopedics and Sports Medicine.

The scientist's work concentrates on key topics including:

  • Hip disorders and treatments
  • Orthopaedic implants and arthroplasty
  • Osteoarthritis treatment and mechanisms
  • Bone and joint diseases
  • Cancer-related molecular mechanisms research
  • Cardiac valve diseases and treatments
  • Bone fractures and treatments

Recent papers authored or co-authored by Regis J. O'Keefe include:

  • LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis, 2020, Nature Communications
  • FoxO1 is a crucial mediator of TGF-β/TAK1 signaling and protects against osteoarthritis by maintaining articular cartilage homeostasis, 2020, Proceedings of the National Academy of Sciences
  • Magnesium facilitates the healing of atypical femoral fractures: A single-cell transcriptomic study, 2022, Materials Today
  • Deletion of Glut1 in early postnatal cartilage reprograms chondrocytes toward enhanced glutamine oxidation, 2021, Bone Research
  • Inflammatory Response of Articular Cartilage to Femoroacetabular Impingement in the Hip, 2020, The American Journal of Sports Medicine

The scientist frequently publishes in venues such as:

  • Orthopaedic Journal of Sports Medicine (7 publications)
  • The American Journal of Sports Medicine (4 publications)
  • Osteoarthritis and Cartilage (3 publications)
  • UNC Libraries (3 publications)
  • Journal of Bone and Joint Surgery (3 publications)

Regis J. O'Keefe has collaborated regularly with several co-authors, including:

  • Cecilia Pascual-Garrido (16 collaborations)
  • Jie Shen (15 collaborations)
  • John C. Clohisy (15 collaborations)
  • Robert H. Brophy (13 collaborations)
  • Tomoyuki Kamenaga (10 collaborations)

Best Publications

  • Atypical subtrochanteric and diaphyseal femoral fractures: Report of a task force of the american society for bone and mineral Research

    Elizabeth Shane;David Burr;Peter R. Ebeling;Bo Abrahamsen

  • Atypical Subtrochanteric and Diaphyseal Femoral Fractures: Report of a Task Force of the American Society for Bone and Mineral Research Running Title: Atypical Femoral Fractures Task Force Report

    Elizabeth Shane;David Burr;Peter R. Ebeling;Bo

  • Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair

    Xinping Zhang;Edward M. Schwarz;Donald A. Young;J. Edward Puzas

  • Activation of β-Catenin Signaling in Articular Chondrocytes Leads to Osteoarthritis-Like Phenotype in Adult β-Catenin Conditional Activation Mice

    Mei Zhu;Dezhi Tang;Dezhi Tang;Qiuqian Wu;Suyang Hao

  • Runx2-mediated regulation of the zinc finger Osterix/Sp7 gene.

    Yasuhiko Nishio;Yufeng Dong;Mark Paris;Regis J. O'Keefe

  • Periosteal Progenitor Cell Fate in Segmental Cortical Bone Graft Transplantations: Implications for Functional Tissue Engineering

    Xinping Zhang;Chao Xie;Angela S P Lin;Hiromu Ito

  • The biology of the growth plate.

    R. Tracy Ballock;Regis J. O'Keefe

  • Articular cartilage biology.

    Michael Ulrich-Vinther;Michael D Maloney;Edward M Schwarz;Randy Rosier

  • Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy

    Hiromu Ito;Hiromu Ito;Mette Koefoed;Prarop Tiyapatanaputi;Kirill Gromov

  • TNFα and pathologic bone resorption

    Brendan E Boyce;Ping Li;Zhenqiang Yao;Qian Zhang

  • Inhibition of β-Catenin Signaling in Articular Chondrocytes Results in Articular Cartilage Destruction

    Mei Zhu;Mo Chen;Michael Zuscik;Qiuqian Wu

  • Bone Tissue Engineering and Regeneration: From Discovery to the Clinic—An Overview

    Regis J. O'Keefe;Jeremy Mao

  • RANK Signaling Is Not Required for TNFα‐Mediated Increase in CD11bhi Osteoclast Precursors but Is Essential for Mature Osteoclast Formation in TNFα‐Mediated Inflammatory Arthritis

    Ping Li;Edward M Schwarz;Regis J O'Keefe;Lin Ma

  • Regulation of chondrogenesis and chondrocyte differentiation by stress

    Michael J. Zuscik;Matthew J Hilton;Xinping Zhang;Di Chen

  • Tumor necrosis factor-alpha/nuclear transcription factor-kappaB signaling in periprosthetic osteolysis.

    E M Schwarz;A P Lu;J J Goater;E B Benz

  • Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor.

    Yu-Feng Dong;Do Y. Soung;Edward M. Schwarz;Regis J. O'Keefe

  • BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development

    Bing Shu;Ming Zhang;Rong Xie;Meina Wang

  • A Perspective: Engineering Periosteum for Structural Bone Graft Healing

    Xinping Zhang;Hani A. Awad;Regis J. O’Keefe;Robert E. Guldberg

  • Proinflammatory cytokines and metalloproteases are expressed in the subacromial bursa in patients with rotator cuff disease.

    Ilya Voloshin;Jill Gelinas;Michael D. Maloney;Regis J. O’Keefe

  • Erratum: Atypical subtrochanteric and diaphyseal femoral fractures: Report of a task force of the American Society for Bone and Mineral Research (Journal of Bone and Mineral Research (2010) 25 (2267-2294))

    Elizabeth Shane;David Burr;Peter R. Ebeling;Bo Abrahamsen

Frequent Co-Authors

Edward M. Schwarz
Edward M. Schwarz University of Rochester Medical Center
Michael J. Zuscik
Michael J. Zuscik University of Rochester
Di Chen
Di Chen Chinese Academy of Sciences
Hicham Drissi
Hicham Drissi Emory University
Brendan F. Boyce
Brendan F. Boyce University of Rochester Medical Center
Kjeld Søballe
Kjeld Søballe Aarhus University Hospital
Louis S. Constine
Louis S. Constine University of Rochester Medical Center
R. John Looney
R. John Looney University of Rochester
Henry J. Mankin
Henry J. Mankin Harvard University
Jeremy J. Mao
Jeremy J. Mao Columbia University

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