World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
70
Citations
18363
World Ranking
6979
National Ranking
217

Overview

Guozhi Xiao is affiliated with the Southern University of Science and Technology in China. Their research primarily focuses on medicine and biochemistry, genetics, and molecular biology.

The scientist's subfields of study include molecular biology, rheumatology, cell biology, immunology and allergy, and genetics. Their work covers several main topics, such as osteoarthritis treatment and mechanisms, bone metabolism and diseases, cell adhesion molecules research, cellular mechanics and interactions, erythrocyte function and pathophysiology, mesenchymal stem cell research, and spine and intervertebral disc pathology.

Guozhi Xiao has contributed to multiple recent papers, including:

  • Osteoarthritis: pathogenic signaling pathways and therapeutic targets, 2023, Signal Transduction and Targeted Therapy
  • Global, regional and national burden of low back pain 1990-2019: A systematic analysis of the Global Burden of Disease study 2019, 2021, Journal of Orthopaedic Translation
  • Molecular mechanosensors in osteocytes, 2020, Bone Research
  • Current understanding of osteoarthritis pathogenesis and relevant new approaches, 2022, Bone Research
  • Metformin limits osteoarthritis development and progression through activation of AMPK signalling, 2020, Annals of the Rheumatic Diseases

Frequent co-authors in their publications include Sixiong Lin, Xiaohao Wu, Xiaochun Bai, Huiling Cao, and Lei Qin.

Guozhi Xiao has published extensively in several journals, notably in Bone Research, Journal of Orthopaedic Translation, bioRxiv (Cold Spring Harbor Laboratory), Signal Transduction and Targeted Therapy, and Frontiers in Cell and Developmental Biology.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Isolation and characterization of MC3T3-E1 preosteoblast subclones with distinct in vitro and in vivo differentiation/mineralization potential.

    Dian Wang;Kurt Christensen;Kanwal Chawla;Guozhi Xiao

  • MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Cbfa1.

    Guozhi Xiao;Di Jiang;Peedikayil Thomas;M.Douglas Benson

  • Regulation of the osteoblast-specific transcription factor, Runx2: Responsiveness to multiple signal transduction pathways

    Renny T. Franceschi;Guozhi Xiao

  • Bone morphogenetic proteins, extracellular matrix, and mitogen-activated protein kinase signaling pathways are required for osteoblast-specific gene expression and differentiation in MC3T3-E1 cells.

    Guozhi Xiao;Rajaram Gopalakrishnan;Di Jiang;Elizabeth Reith

  • Engineering new bone tissue in vitro on highly porous poly(α-hydroxyl acids)/hydroxyapatite composite scaffolds

    Peter X. Ma;Ruiyun Zhang;Guozhi Xiao;Renny T. Franceschi

  • Transcriptional regulation of osteoblasts.

    Renny T. Franceschi;Chunxi Ge;Guozhi Xiao;Hernan Roca

  • Critical role of the extracellular signal–regulated kinase–MAPK pathway in osteoblast differentiation and skeletal development

    Chunxi Ge;Guozhi Xiao;Di Jiang;Renny T. Franceschi

  • Fibroblast Growth Factor 2 Induction of the Osteocalcin Gene Requires MAPK Activity and Phosphorylation of the Osteoblast Transcription Factor, Cbfa1/Runx2

    Guozhi Xiao;Di Jiang;Rajaram Gopalakrishnan;Renny T. Franceschi

  • Role of the α2-Integrin in Osteoblast-specific Gene Expression and Activation of the Osf2 Transcription Factor

    Guozhi Xiao;Dian Wang;M. Douglas Benson;Gerard Karsenty

  • Molecular mechanosensors in osteocytes

    Lei Qin;Wen Liu;Huiling Cao;Guozhi Xiao

  • Multiple Signaling Pathways Converge on the Cbfa1/Runx2 Transcription Factor to Regulate Osteoblast Differentiation

    Renny T. Franceschi;Guozhi Xiao;Di Jiang;Rajaram Gopalakrishnan

  • Monocyte chemotactic protein-1 (MCP-1) acts as a paracrine and autocrine factor for prostate cancer growth and invasion.

    Yi Lu;Yi Lu;Zhong Cai;Zhong Cai;Deborah L. Galson;Guozhi Xiao

  • Cooperative interactions between activating transcription factor 4 and Runx2/Cbfa1 stimulate osteoblast-specific osteocalcin gene expression

    Guozhi Xiao;Di Jiang;Chunxi Ge;Zhuoran Zhao

  • Global, regional and national burden of low back pain 1990–2019: A systematic analysis of the Global Burden of Disease study 2019

    Sheng Chen;Sheng Chen;Mingjue Chen;Xiaohao Wu;Sixiong Lin;Sixiong Lin

  • Macrophage endocytosis of high-mobility group box 1 triggers pyroptosis

    J Xu;Y Jiang;J Wang;X Shi

  • Identification and Functional Characterization of ERK/MAPK Phosphorylation Sites in the Runx2 Transcription Factor

    Chunxi Ge;Guozhi Xiao;Di Jiang;Qian Yang

  • Ascorbic Acid-Dependent Activation of the Osteocalcin Promoter in MC3T3-E1 Preosteoblasts: Requirement for Collagen Matrix Synthesis and the Presence of an Intact OSE2 Sequence

    Guozhi Xiao;Yingqi Cui;Patricia Ducy;Gerard Karsenty

  • MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint.

    Hongxu Yang;Yi Wen;Mian Zhang;Qian Liu

  • Bone Morphogenetic Protein 2 Induces Dental Follicle Cells to Differentiate Toward a Cementoblast/Osteoblast Phenotype

    Ming Zhao;Guozhi Xiao;Janice E. Berry;Renny T. Franceschi

Frequent Co-Authors

Di Chen
Di Chen Chinese Academy of Sciences
Jie Fan
Jie Fan University of Pittsburgh
Renny T. Franceschi
Renny T. Franceschi University of Michigan–Ann Arbor
Hee-Jeong Im
Hee-Jeong Im University of Illinois at Chicago
Chuanyue Wu
Chuanyue Wu University of Pittsburgh
Timothy R. Billiar
Timothy R. Billiar University of Pittsburgh
Chuan-ju Liu
Chuan-ju Liu New York University
G. David Roodman
G. David Roodman Indiana University
Howard S. An
Howard S. An Rush University Medical Center
Song Li
Song Li University of Pittsburgh

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