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Medicine

D-Index
84
Citations
25210
World Ranking
15129
National Ranking
7641

Research.com Recognitions

  • 2008 - Fellow of John Simon Guggenheim Memorial Foundation
  • 2007 - Fellow of the American Association for the Advancement of Science (AAAS)
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Jason X.-J. Yuan is affiliated with the University of California, San Diego in the United States. Their research primarily focuses on pulmonary and respiratory medicine, with significant contributions also in molecular biology, cardiology and cardiovascular medicine, physiology, and surgery. Their work spans interdisciplinary areas within medicine and biochemistry, genetics, and molecular biology.

Yuan's main topics of research include:

  • Pulmonary Hypertension Research and Treatments
  • Chronic Obstructive Pulmonary Disease (COPD) Research
  • Cardiovascular Function and Risk Factors
  • Erythrocyte Function and Pathophysiology
  • Ion Channels and Receptors
  • Ion channel regulation and function
  • Nitric Oxide and Endothelin Effects

Frequent co-authors who have collaborated extensively with Yuan are:

  • Jian Wang
  • Ayako Makino
  • Pritesh Jain
  • Aleksandra Babicheva
  • Patricia A. Thistlethwaite

The scientist has published regularly in these venues:

  • The FASEB Journal
  • British Journal of Pharmacology
  • Pulmonary Circulation
  • American Journal of Respiratory and Critical Care Medicine
  • Physiology

Among their recent papers are:

  • "MDM2-Mediated Ubiquitination of Angiotensin-Converting Enzyme 2 Contributes to the Development of Pulmonary Arterial Hypertension" (2020), Circulation
  • "Endothelial upregulation of mechanosensitive channel Piezo1 in pulmonary hypertension" (2021), American Journal of Physiology-Cell Physiology
  • "Clinical Characteristics and Transplant-Free Survival Across the Spectrum of Pulmonary Vascular Disease" (2022), Journal of the American College of Cardiology
  • "Upregulation of Piezo1 (Piezo Type Mechanosensitive Ion Channel Component 1) Enhances the Intracellular Free Calcium in Pulmonary Arterial Smooth Muscle Cells From Idiopathic Pulmonary Arterial Hypertension Patients" (2021), Hypertension
  • "Pathophysiology and pathogenic mechanisms of pulmonary hypertension: role of membrane receptors, ion channels, and Ca2+ signaling" (2022), Physiological Reviews

Yuan has received recognition in the form of fellowships and memberships, including:

  • Fellow of John Simon Guggenheim Memorial Foundation (2008)
  • Fellow of the American Association for the Advancement of Science (AAAS) (2007)
  • Member of the Association of American Physicians

Best Publications

  • Postnatal isl1 + cardioblasts enter fully differentiated cardiomyocyte lineages

    Karl Ludwig Laugwitz;Alessandra Moretti;Jason Lam;Peter Gruber

  • Cellular and molecular basis of pulmonary arterial hypertension.

    Nicholas W. Morrell;Serge Adnot;Stephen L. Archer;Jocelyn Dupuis

  • Inflammation, growth factors, and pulmonary vascular remodeling.

    Paul M. Hassoun;Luc Mouthon;Joan A. Barberà;Saadia Eddahibi

  • Dysfunctional Voltage-Gated K+ Channels in Pulmonary Artery Smooth Muscle Cells of Patients With Primary Pulmonary Hypertension

    Jason Xiao Jian Yuan;Ann M. Aldinger;Magdalena Juhaszova;Jian Wang

  • Risk factors and basic mechanisms of chronic thromboembolic pulmonary hypertension: a current understanding

    Irene M. Lang;Raffaele Pesavento;Diana Bonderman;Jason X.-J. Yuan

  • Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension

    Ying Yu;Ivana Fantozzi;Carmelle V. Remillard;Judd W. Landsberg

  • SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2.

    Yuyang Lei;Jiao Zhang;Jiao Zhang;Cara R. Schiavon;Ming He

  • Signaling molecules in nonfamilial pulmonary hypertension.

    Lingling Du;Christopher C. Sullivan;Danny Chu;Augustine J. Cho

  • Upregulated TRP and enhanced capacitative Ca2+ entry in human pulmonary artery myocytes during proliferation

    Vera A. Golovina;Oleksandr Platoshyn;Colleen L. Bailey;Jian Wang

  • Cellular and molecular mechanisms of pulmonary vascular remodeling: role in the development of pulmonary hypertension.

    Mehran Mandegar;Yuan Cheng B. Fung;Wei Huang;Carmelle V. Remillard

  • PDGF stimulates pulmonary vascular smooth muscle cell proliferation by upregulating TRPC6 expression.

    Ying Yu;Michele Sweeney;Shen Zhang;Oleksandr Platoshyn

  • Notch3 signaling promotes the development of pulmonary arterial hypertension

    Xiaodong Li;Xiaoxue Zhang;Robin Leathers;Ayako Makino

  • Activation of K+ channels: an essential pathway in programmed cell death

    Carmelle V. Remillard;Jason X.-J. Yuan

  • Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells

    Shen Zhang;Ivana Fantozzi;Donna D. Tigno;Eunhee S. Yi

  • Inhibition of endogenous TRP1 decreases capacitative Ca2+ entry and attenuates pulmonary artery smooth muscle cell proliferation.

    Michele Sweeney;Ying Yu;Oleksandr Platoshyn;Shen Zhang

  • Mechanisms of Hybrid Oligomer Formation in the Pathogenesis of Combined Alzheimer's and Parkinson's Diseases

    Igor F. Tsigelny;Leslie Crews;Paula Desplats;Gideon M. Shaked

  • Angiotensin-(1–7) binds to specific receptors on cardiac fibroblasts to initiate antifibrotic and antitrophic effects

    Michikado Iwata;Randy T. Cowling;Devorah Gurantz;Cristina Moore

  • Persistent eNOS activation secondary to caveolin-1 deficiency induces pulmonary hypertension in mice and humans through PKG nitration

    You Yang Zhao;Yidan D. Zhao;Muhammad K. Mirza;Julia H. Huang

  • Pathogenesis of Pulmonary Arterial Hypertension The Need for Multiple Hits

    Jason X.-J. Yuan;Lewis J. Rubin

  • Hypoxia increases AP-1 binding activity by enhancing capacitative Ca2+ entry in human pulmonary artery endothelial cells

    Ivana Fantozzi;Shen Zhang;Oleksandr Platoshyn;Carmelle V. Remillard

Frequent Co-Authors

Joe G.N. Garcia
Joe G.N. Garcia University of Arizona
Stephen M. Black
Stephen M. Black Florida International University
Ying Yu
Ying Yu Central China Normal University
Lewis J. Rubin
Lewis J. Rubin University of California, San Diego
Nicholas W. Morrell
Nicholas W. Morrell University of Cambridge
John Y.-J. Shyy
John Y.-J. Shyy University of California, San Diego
Paul A. Insel
Paul A. Insel University of California, San Diego
Ting Wang
Ting Wang Washington University in St. Louis
Wolfgang H. Dillmann
Wolfgang H. Dillmann University of California, San Diego
Jaladanki N. Rao
Jaladanki N. Rao University of Maryland, Baltimore

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