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Gregory V. Kryukov

Gregory V. Kryukov

D-Index & Metrics

Genetics

D-Index
60
Citations
50392
World Ranking
3091
National Ranking
1348

Overview

Gregory V. Kryukov is affiliated with the Broad Institute in the United States and has contributed to research primarily in the fields of biochemistry, genetics, molecular biology, and medicine. Their research spans several interrelated subfields including molecular biology, oncology, cancer research, genetics, and pulmonary and respiratory medicine.

The scientist's work covers a variety of topics with a focus on CRISPR and genetic engineering, CAR-T cell therapy research, cancer genomics and diagnostics, gene expression and cancer classification, click chemistry and its applications, PI3K/AKT/mTOR signaling pathways in cancer, and the relationship between metabolism, diabetes, and cancer.

Gregory V. Kryukov's recent notable publications include:

  • Quantitative Proteomics of the Cancer Cell Line Encyclopedia, 2020, Cell
  • DrugMap: A quantitative pan-cancer analysis of cysteine ligandability, 2024, Cell
  • STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts, 2023, Cancer Discovery
  • Rational design of a SOCS1-edited tumor-infiltrating lymphocyte therapy using CRISPR/Cas9 screens, 2023, Journal of Clinical Investigation
  • Precision Oncology Comes of Age: Designing Best-in-Class Small Molecules by Integrating Two Decades of Advances in Chemistry, Target Biology, and Data Science, 2023, Cancer Discovery

Frequent collaborators of Kryukov include:

  • Frank Stegmeier
  • Natasja Brooijmans
  • Brendan J. Hilbert
  • Angel Guzman-Perez
  • Darrin D. Stuart

Gregory V. Kryukov has published most often in the following scientific venues:

  • Cell
  • Cancer Discovery
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Journal of Clinical Investigation

Best Publications

  • The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

    Jordi Barretina;Giordano Caponigro;Nicolas Stransky;Kavitha Venkatesan

  • Mutational heterogeneity in cancer and the search for new cancer-associated genes

    Michael S. Lawrence;Petar Stojanov;Petar Stojanov;Paz Polak;Paz Polak;Paz Polak;Gregory V. Kryukov;Gregory V. Kryukov;Gregory V. Kryukov

  • A landscape of driver mutations in melanoma

    Eran Hodis;Ian R. Watson;Ian R. Watson;Gregory V. Kryukov;Gregory V. Kryukov;Gregory V. Kryukov;Stefan T. Arold

  • Characterization of Mammalian Selenoproteomes

    Gregory V. Kryukov;Sergi Castellano;Sergey V. Novoselov;Sergey V. Novoselov;Alexey V. Lobanov;Alexey V. Lobanov

  • Next-generation characterization of the Cancer Cell Line Encyclopedia

    Mahmoud Ghandi;Franklin W. Huang;Franklin W. Huang;Franklin W. Huang;Judit Jané-Valbuena;Judit Jané-Valbuena;Gregory V. Kryukov

  • Defining a Cancer Dependency Map

    Aviad Tsherniak;Francisca Vazquez;Francisca Vazquez;Phil G. Montgomery;Barbara A. Weir;Barbara A. Weir

  • Highly Recurrent TERT Promoter Mutations in Human Melanoma

    Franklin W. Huang;Franklin W. Huang;Eran Hodis;Eran Hodis;Eran Hodis;Mary Jue Xu;Mary Jue Xu;Mary Jue Xu;Gregory V. Kryukov

  • Punctuated Evolution of Prostate Cancer Genomes

    Sylvan C Baca;Davide Prandi;Michael S Lawrence;Juan Miguel Mosquera

  • An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers

    Steven A Roberts;Michael S Lawrence;Leszek J Klimczak;Sara A Grimm

  • The Genetic Landscape of Clinical Resistance to RAF Inhibition in Metastatic Melanoma

    Eliezer M. Van Allen;Eliezer M. Van Allen;Nikhil Wagle;Nikhil Wagle;Antje Sucker;Daniel J. Treacy

  • Pooled Association Tests for Rare Variants in Exon-Resequencing Studies

    Alkes L. Price;Gregory V. Kryukov;Gregory V. Kryukov;Paul I.W. de Bakker;Paul I.W. de Bakker;Shaun M. Purcell;Shaun M. Purcell

  • Quantitative Proteomics of the Cancer Cell Line Encyclopedia

    David P. Nusinow;John Szpyt;Mahmoud Ghandi;Christopher M. Rose

  • An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules

    Amrita Basu;Nicole E. Bodycombe;Jaime H. Cheah;Edmund V. Price

  • Most Rare Missense Alleles Are Deleterious in Humans: Implications for Complex Disease and Association Studies

    Gregory V. Kryukov;Len A. Pennacchio;Len A. Pennacchio;Shamil R. Sunyaev

  • Genome sequencing reveals insights into physiology and longevity of the naked mole rat

    Eun Bae Kim;Xiaodong Fang;Alexey A. Fushan;Zhiyong Huang

  • Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer.

    Aria Vaishnavi;Marzia Capelletti;Anh T Le;Severine Kako

  • Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting

    Andrew J Aguirre;Robin M Meyers;Barbara A. Weir;Francisca Vázquez

  • Somatic ERCC2 Mutations Correlate with Cisplatin Sensitivity in Muscle-Invasive Urothelial Carcinoma

    Eliezer M Van Allen;Kent W. Mouw;Philip Kim;Gopa Iyer

  • Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine

    Eliezer M Van Allen;Nikhil Wagle;Petar Stojanov;Danielle L Perrin

  • MAP Kinase Pathway Alterations in BRAF-Mutant Melanoma Patients with Acquired Resistance to Combined RAF/MEK Inhibition

    Nikhil Wagle;Nikhil Wagle;Eliezer M. Van Allen;Eliezer M. Van Allen;Daniel J. Treacy;Dennie T. Frederick

Frequent Co-Authors

Levi A. Garraway
Levi A. Garraway Roche (United States)
Vadim N. Gladyshev
Vadim N. Gladyshev Brigham and Women's Hospital
Gad Getz
Gad Getz Broad Institute
Todd R. Golub
Todd R. Golub Harvard University
Shamil R. Sunyaev
Shamil R. Sunyaev Harvard University
William C. Hahn
William C. Hahn Dana-Farber Cancer Institute
Eliezer M. Van Allen
Eliezer M. Van Allen Harvard University
William R. Sellers
William R. Sellers Harvard University
Dolph L. Hatfield
Dolph L. Hatfield National Institutes of Health
Matthew Meyerson
Matthew Meyerson Harvard University

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