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Genetics

D-Index
56
Citations
12038
World Ranking
3494
National Ranking
417

Overview

Gavin Hudson is affiliated with Newcastle University in the United Kingdom. Their research predominantly focuses on the field of Biochemistry, Genetics and Molecular Biology, with a total of 67 publications. Within this main discipline, they have contributed extensively to Molecular Biology, Clinical Biochemistry, and Neurology, alongside work in Cellular and Molecular Neuroscience and Cancer Research.

Their research addresses several key topics, which include:

  • Mitochondrial Function and Pathology
  • Metabolism and Genetic Disorders
  • Parkinson's Disease Mechanisms and Treatments
  • Metabolomics and Mass Spectrometry Studies
  • RNA modifications and cancer
  • Genetic Neurodegenerative Diseases
  • Single-cell and spatial transcriptomics

Gavin Hudson has authored numerous scientific papers, with some recent notable publications as follows:

  • Age-associated mitochondrial DNA mutations cause metabolic remodeling that contributes to accelerated intestinal tumorigenesis, 2020, Nature Cancer
  • GBA and APOE Impact Cognitive Decline in Parkinson's Disease: A 10-Year Population-Based Study, 2022, Movement Disorders
  • Circulating cell-free mitochondrial DNA levels in Parkinson's disease are influenced by treatment, 2020, Molecular Neurodegeneration
  • The genetics of mitochondrial disease: dissecting mitochondrial pathology using multi-omic pipelines, 2021, The Journal of Pathology
  • Heteroplasmic mitochondrial DNA variants in cardiovascular diseases, 2022, PLoS Genetics

The scientist frequently publishes in several journals including:

  • Scientific Reports
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Movement Disorders
  • npj Parkinson's Disease
  • Nature Cancer

Their collaborative network includes frequent co-authors such as:

  • Angela Pyle
  • Douglass M. Turnbull
  • Amy E. Vincent
  • Alexander G. Bury
  • Paolo Actis

Best Publications

  • Mutation of OPA1 causes dominant optic atrophy with external ophthalmoplegia, ataxia, deafness and multiple mitochondrial DNA deletions: a novel disorder of mtDNA maintenance.

    Gavin Hudson;Patrizia Amati-Bonneau;Emma L. Blakely;Joanna D. Stewart

  • Characterizing mild cognitive impairment in incident Parkinson disease The ICICLE-PD Study

    Alison J Yarnall;David P Breen;Gordon W Duncan;Tien K Khoo

  • Inherited mitochondrial optic neuropathies

    Patrick Yu-Wai-Man;Philip G Griffiths;Gavin Hudson;Patrick F Chinnery

  • Multi-system neurological disease is common in patients with OPA1 mutations

    Patrick Yu-Wai-Man;Philip G. Griffiths;Philip G. Griffiths;G. Gorman;C.-M. Lourenco

  • Excessive burden of lysosomal storage disorder gene variants in Parkinson's disease

    L.A. Robak;L.A. Robak;I.E. Jansen;I.E. Jansen;J van Rooij;A.G. Uitterlinden

  • Loss of VPS13C Function in Autosomal-Recessive Parkinsonism Causes Mitochondrial Dysfunction and Increases PINK1/Parkin-Dependent Mitophagy.

    Suzanne Lesage;Valérie Drouet;Elisa Majounie;Vincent Deramecourt

  • Phenotypic spectrum associated with mutations of the mitochondrial polymerase γ gene

    R Horvath;G Hudson;G Ferrari;N Futterer

  • Clinical Expression of Leber Hereditary Optic Neuropathy Is Affected by the Mitochondrial DNA–Haplogroup Background

    Gavin Hudson;Valerio Carelli;Valerio Carelli;Liesbeth Spruijt;Mike Gerards

  • Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease

    A. Beilina;I. N. Rudenko;A. Kaganovich;L. Civiero

  • Whole-genome sequencing of patients with rare diseases in a national health system

    Ernest Turro;William J Astle;Karyn Megy;Stefan Graf

  • A Two-Stage Meta-Analysis Identifies Several New Loci for Parkinson's Disease

    V. Plagnol;M.A. Nalls;J.M. Bras;D.G. Hernandez;D.G. Hernandez

  • Efficient mitochondrial biogenesis drives incomplete penetrance in Leber's hereditary optic neuropathy.

    Carla Giordano;Luisa Iommarini;Luca Giordano;Alessandra Maresca

  • Mitochondrial DNA polymerase-γ and human disease

    Gavin Hudson;Patrick F. Chinnery

  • Mutant POLG2 Disrupts DNA Polymerase γ Subunits and Causes Progressive External Ophthalmoplegia

    Matthew J. Longley;Susanna Clark;Cynthia Yu Wai Man;Gavin Hudson

  • A founder mutation in Anoctamin 5 is a major cause of limb girdle muscular dystrophy

    Debbie Hicks;A Sarkozy;N Muelas;K Koehler

  • Reduced mitochondrial DNA copy number is a biomarker of Parkinson's disease

    Angela Pyle;Haidyan Anugrha;Marzena Kurzawa-Akanbi;Alison Yarnall

  • Epigenetics, epidemiology and mitochondrial DNA diseases

    Patrick Francis Chinnery;Hannah R Elliott;Gavin Hudson;David C Samuels

  • Identification of an X-Chromosomal Locus and Haplotype Modulating the Phenotype of a Mitochondrial DNA Disorder

    Gavin Hudson;Sharon Keers;Patrick Yu Wai Man;Philip Griffiths

  • Phenotypic spectrum associated with mutations of the mitochondrial polymerase γ gene. Commentary

    Salvatore Dimauro;Guido Davidzon;Michio Hirano;Rita Horvath

  • Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21

    C. C. Spencer;V. Plagnol;A. Strange;M. Gardner

Frequent Co-Authors

Patrick F. Chinnery
Patrick F. Chinnery University of Cambridge
Angela Pyle
Angela Pyle Newcastle University
Robert W. Taylor
Robert W. Taylor Newcastle University
David J. Burn
David J. Burn Newcastle University
Rita Horvath
Rita Horvath University of Cambridge
Douglass M. Turnbull
Douglass M. Turnbull Newcastle University
Patrick Yu-Wai-Man
Patrick Yu-Wai-Man University of Cambridge
Hanns Lochmüller
Hanns Lochmüller University of Freiburg
Massimo Zeviani
Massimo Zeviani University of Padua
Robert McFarland
Robert McFarland Newcastle University

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