Jacek Biernat

Overview

Best Publications

• Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure.

  M. von Bergen;P. Friedhoff;J. Biernat;J. Heberle

  1231
  Citations

• Indirubins Inhibit Glycogen Synthase Kinase-3β and CDK5/P25, Two Protein Kinases Involved in Abnormal Tau Phosphorylation in Alzheimer's Disease A PROPERTY COMMON TO MOST CYCLIN-DEPENDENT KINASE INHIBITORS?

  Sophie Leclerc;Matthieu Garnier;Ralph Hoessel;Doris Marko

  1102
  Citations

• Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: Distinction between PHF-like immunoreactivity and microtubule binding

  J Biernat;N Gustke;G Drewes;E M Mandelkow

  989
  Citations

• Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau

  Susmitha Ambadipudi;Jacek Biernat;Dietmar Riedel;Eckhard Mandelkow

  783
  Citations

• Domains of tau protein and interactions with microtubules.

  N. Gustke;B. Trinczek;J. Biernat;E.-M. Mandelkow

  772
  Citations

• Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state.

  G Drewes;B Lichtenberg-Kraag;F Döring;E M Mandelkow

  766
  Citations

• Structural Polymorphism of 441-Residue Tau at Single Residue Resolution

  Marco D Mukrasch;Stefan Bibow;Jegannath Korukottu;Sadasivam Jeganathan

  725
  Citations

• Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau

  E.-M. Mandelkow;G. Drewes;J. Biernat;N. Gustke

  713
  Citations

• RNA stimulates aggregation of microtubule-associated protein tau into Alzheimer-like paired helical filaments

  T. Kampers;P. Friedhoff;J. Biernat;E.-M. Mandelkow

  682
  Citations

• Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin-dependent kinases cdk2 and cdk5

  K. Baumann;E. M. Mandelkow;J. Biernat;Helen Piwnica-Worms

  654
  Citations

• Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local beta-structure.

  Martin von Bergen;Stefan Barghorn;Li Li;Alexander Marx

  645
  Citations

• Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments.

  A Schneider;J Biernat;M von Bergen;E Mandelkow

  642
  Citations

• The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region

  J. Biernat;E.M. Mandelkow;C. Schröter;B. Lichtenberg-Kraag

  606
  Citations

• Inhibition of cyclin-dependent kinases, GSK-3β and CK1 by hymenialdisine, a marine sponge constituent

  L. Meijer;A. M W H Thunnissen;A. W. White;M. Garnier

  597
  Citations

• Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro.

  H Wille;G Drewes;J Biernat;E M Mandelkow

  595
  Citations

• Tau stabilizes microtubules by binding at the interface between tubulin heterodimers

  Harindranath Kadavath;Romina V. Hofele;Jacek Biernat;Satish Kumar

  588
  Citations

• Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filaments.

  Olaf Schweers;Eva-Maria Mandelkow;Jacek Biernat;Eckhard Mandelkow

  506
  Citations

• Paullones are potent inhibitors of glycogen synthase kinase‐3β and cyclin‐dependent kinase 5/p25

  Maryse Leost;Christiane Schultz;Andreas Link;Yong Zhong Wu

  497
  Citations

• Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation.

  Qingyi Zheng-Fischhöfer;Jacek Biernat;Eva-Maria Mandelkow;Susanne Illenberger

  456
  Citations

• Inducible Expression of Tau Repeat Domain in Cell Models of Tauopathy AGGREGATION IS TOXIC TO CELLS BUT CAN BE REVERSED BY INHIBITOR DRUGS

  Inna Khlistunova;Jacek Biernat;Yipeng Wang;Marcus Pickhardt

  435
  Citations