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Maria Grazia Spillantini

Maria Grazia Spillantini

D-Index & Metrics

Neuroscience

D-Index
109
Citations
65839
World Ranking
548
National Ranking
70

Research.com Recognitions

  • 2013 - Fellow of the Royal Society, United Kingdom
  • 2000 - Potamkin Prize for Research in Pick's, Alzheimer's, and Related Diseases, American Academy of Neurology
  • 2000 - Sedgwick Memorial Medal, American Public Health Association
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom

Overview

Maria Grazia Spillantini is affiliated with the University of Cambridge in the United Kingdom. Their research primarily focuses on medical and neuroscience fields, with notable specialization in neurology and physiology. The work also spans molecular biology, cellular and molecular neuroscience, and cell biology.

The main topics within their research include:

  • Parkinson's Disease Mechanisms and Treatments
  • Alzheimer's disease research and treatments
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Neurological disorders and treatments
  • Nuclear Receptors and Signaling
  • S100 Proteins and Annexins
  • Botulinum Toxin and Related Neurological Disorders

Among their recent publications are:

  • The pathogenesis of Parkinson's disease, 2024, The Lancet
  • Age-dependent formation of TMEM106B amyloid filaments in human brains, 2022, Nature
  • Microglia become hypofunctional and release metalloproteases and tau seeds when phagocytosing live neurons with P301S tau aggregates, 2021, Science Advances
  • Safety, tolerability and pharmacokinetics of the oligomer modulator anle138b with exposure levels sufficient for therapeutic efficacy in a murine Parkinson model: A randomised, double-blind, placebo-controlled phase 1a trial, 2022, EBioMedicine
  • New SNCA mutation and structures of α-synuclein filaments from juvenile-onset synucleinopathy, 2023, Acta Neuropathologica

The venues they frequently publish in include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Acta Neuropathologica Communications
  • Acta Neuropathologica
  • Brain
  • Neurobiology of Disease

Their collaborations involve frequent co-authorship with several researchers, including:

  • Michel Goedert
  • Mehtap Bacioglu
  • Bernardino Ghetti
  • Sjors H. W. Scheres
  • David Klenerman

In addition to numerous articles, Maria Grazia Spillantini has contributed to book publications, including a title published by Springer Nature:

  • Frontotemporal Dementias, 2021

Maria Grazia Spillantini has received several awards throughout their career, such as:

  • Fellow of the Royal Society, United Kingdom (2013)
  • Sedgwick Memorial Medal, American Public Health Association (2000)
  • Potamkin Prize for Research in Pick's, Alzheimer's, and Related Diseases, American Academy of Neurology (2000)
  • Fellow of The Academy of Medical Sciences, United Kingdom

Best Publications

  • Alpha-synuclein in Lewy bodies.

    Maria Grazia Spillantini;Marie Luise Schmidt;Virginia M.-Y. Lee;John Q. Trojanowski

  • α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies

    M G Spillantini;R A Crowther;R Jakes;M Hasegawa

  • Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

    M. Goedert;M.G. Spillantini;R. Jakes;D. Rutherford

  • A Century of Alzheimer's Disease

    Michel Goedert;Maria Grazia Spillantini

  • Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

    Maria Grazia Spillantini;Jill R. Murrell;Michel Goedert;Martin R. Farlow

  • Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain.

    M Goedert;M G Spillantini;M C Potier;J Ulrich

  • Tau proteins of alzheimer paired helical filaments: Abnormal phosphorylation of all six brain isoforms

    M. Goedert;M.G. Spillantini;N.J. Cairns;R.A. Crowther

  • 100 years of Lewy pathology

    Michel Goedert;Maria Grazia Spillantini;Kelly Del Tredici;Heiko Braak

  • Identification of two distinct synucleins from human brain

    Ross Jakes;Maria Grazia Spillantini;Michel Goedert

  • Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans

    M. Goedert;R. Jakes;M. G. Spillantini;M. G. Spillantini;M. Hasegawa

  • Tau pathology and neurodegeneration

    Maria Grazia Spillantini;Michel Goedert

  • Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies

    M G Spillantini;R A Crowther;R Jakes;N J Cairns

  • Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia

    Gaia Skibinski;Nicholas J Parkinson;Jeremy M Brown;Lisa Chakrabarti;Lisa Chakrabarti

  • Abundant Tau Filaments and Nonapoptotic Neurodegeneration in Transgenic Mice Expressing Human P301S Tau Protein

    Bridget Allen;Esther Ingram;Masaki Takao;Michael J. Smith

  • Tau protein pathology in neurodegenerative diseases

    Maria Grazia Spillantini;Michel Goedert

  • The pathogenesis of Parkinson's disease

    Unknown

  • Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice.

    Francisco Pan-Montojo;Francisco Pan-Montojo;Oleg Anichtchik;Yanina Dening;Lilla Knels

  • Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions

    Vivianna M. Van Deerlin;Patrick M A Sleiman;Maria Martinez-Lage;Maria Martinez-Lage;Alice Chen-Plotkin

  • The Synucleinopathies: Twenty Years On.

    Michel Goedert;Ross Jakes;Maria Grazia Spillantini

  • The α-Synucleinopathies: Parkinson's Disease, Dementia with Lewy Bodies, and Multiple System Atrophy

    Maria Grazia Spillantini;Michel Goedert

  • Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17: A New Group of Tauopathies

    Maria Grazia Spillantini;Thomas D. Bird;Bernardino Ghetti

Frequent Co-Authors

Michel Goedert
Michel Goedert MRC Laboratory of Molecular Biology
John R. Hodges
John R. Hodges University of Sydney
Glenda M. Halliday
Glenda M. Halliday University of Sydney
James B. Rowe
James B. Rowe University of Cambridge
Peter Heutink
Peter Heutink German Center for Neurodegenerative Diseases
Martin R. Farlow
Martin R. Farlow Indiana University
James W. Fawcett
James W. Fawcett University of Cambridge
John Q. Trojanowski
John Q. Trojanowski University of Pennsylvania
Martin N. Rossor
Martin N. Rossor University College London
Roger A. Barker
Roger A. Barker University of Cambridge

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