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Medicine

D-Index
74
Citations
39759
World Ranking
19254
National Ranking
1736

Overview

R. Anthony Crowther is affiliated with the MRC Laboratory of Molecular Biology in the United Kingdom. Their research spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with a strong focus on Molecular Biology, Physiology, Neurology, Structural Biology, and Surfaces, Coatings and Films as subfields of study.

The scientist's primary research topics include Alzheimer's disease research and treatments, prion diseases and protein misfolding, protein structure and dynamics, neuroinflammation and neurodegeneration mechanisms, advanced electron microscopy techniques and applications, electron and X-ray spectroscopy techniques, and ATP synthase and ATPases research.

Recent publications highlight involvement in studying tau filaments and neurodegeneration:

  • "Cryo-EM structures of tau filaments from the brains of mice transgenic for human mutant P301S Tau", 2023, Acta Neuropathologica Communications
  • "Tau and neurodegeneration", 2023, Cytoskeleton
  • "Cryo-EM structures of Tau filaments from the brains of mice transgenic for human mutant P301S Tau", 2023, bioRxiv (Cold Spring Harbor Laboratory)
  • "MRC2020: improvements to Ximdisp and the MRC image-processing programs", 2023, IUCrJ
  • "Sir Aaron Klug OM. 11 August 1926-20 November 2018", 2020, Biographical Memoirs of Fellows of the Royal Society

Frequent co-authors with whom Crowther has collaborated include Sjors H. W. Scheres, Michel Goedert, Manuel Schweighauser, Alexey G. Murzin, and Jennifer A. Macdonald.

The majority of their publications appear in venues such as Biographical Memoirs of Fellows of the Royal Society, Acta Neuropathologica Communications, Cytoskeleton, bioRxiv (Cold Spring Harbor Laboratory), and IUCrJ.

Best Publications

  • Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

    M. Goedert;M.G. Spillantini;R. Jakes;D. Rutherford

  • Transmission and spreading of tauopathy in transgenic mouse brain

    Florence Clavaguera;Tristan Bolmont;R. Anthony Crowther;Dorothee Abramowski

  • Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain.

    M Goedert;M G Spillantini;M C Potier;J Ulrich

  • Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau

    M Goedert;C M Wischik;R A Crowther;J E Walker

  • Tau proteins of alzheimer paired helical filaments: Abnormal phosphorylation of all six brain isoforms

    M. Goedert;M.G. Spillantini;N.J. Cairns;R.A. Crowther

  • Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans

    M. Goedert;R. Jakes;M. G. Spillantini;M. G. Spillantini;M. Hasegawa

  • Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies

    M G Spillantini;R A Crowther;R Jakes;N J Cairns

  • Brain homogenates from human tauopathies induce tau inclusions in mouse brain.

    Florence Clavaguera;Hiroyasu Akatsu;Graham Fraser;R. Anthony Crowther

  • The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development.

    M. Goedert;R. Jakes;R. A. Crowther;J. Six

  • Synthetic filaments assembled from C-terminally truncated α-synuclein

    R.Anthony Crowther;Ross Jakes;Maria Grazia Spillantini;Michel Goedert

  • Propagation of Tau Aggregates and Neurodegeneration.

    Michel Goedert;David S Eisenberg;R Anthony Crowther

  • Familial multiple system tauopathy with presenile dementia: A disease with abundant neuronal and glial tau filaments

    Maria Grazia Spillantini;Michel Goedert;R. Anthony Crowther;Jill R. Murrell

  • Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease : identification of phosphorylation sites in tau-protein

    M Goedert;R Jakes;R A Crowther;P Cohen

  • Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein

    A. Probst;J. Götz;K. H. Wiederhold;M. Tolnay

  • Molecular characterization of microtubule-associated proteins tau and map2

    M. Goedert;M. Goedert;R.A. Crowther;R.A. Crowther;C.C. Garner;C.C. Garner

  • Tau filaments from human brain and from in vitro assembly of recombinant protein show cross-β structure

    John Berriman;Louise C. Serpell;Keith A. Oberg;Anthony L. Fink

  • Tau mutations cause frontotemporal dementias.

    Michel Goedert;R.Anthony Crowther;Maria Grazia Spillantini

  • Effects of frontotemporal dementia FTDP-17 mutations on heparin-induced assembly of tau filaments

    Michel Goedert;Ross Jakes;R.Anthony Crowther

  • Tau Pathology in Two Dutch Families with Mutations in the Microtubule-Binding Region of Tau

    M.G. Spillantini;R.A. Crowther;W. Kamphorst;P. Heutink

  • TRANSMISSION AND SPREADING OF TAUOPATHIES IN TRANSGENIC MOUSE BRAIN

    Florence Clavaguera;Bernardino Ghetti;Gabriel Schweighauser;Hiroyasu Akatsu

Frequent Co-Authors

Michel Goedert
Michel Goedert MRC Laboratory of Molecular Biology
Maria Grazia Spillantini
Maria Grazia Spillantini University of Cambridge
Bernardino Ghetti
Bernardino Ghetti Indiana University
Ross Jakes
Ross Jakes MRC Laboratory of Molecular Biology
Mike Smith
Mike Smith Duke University
Louise C. Serpell
Louise C. Serpell University of Sussex
John R. Hodges
John R. Hodges University of Sydney
Aaron Klug
Aaron Klug MRC Laboratory of Molecular Biology
Matthias Staufenbiel
Matthias Staufenbiel University of Tübingen
Gerard D. Schellenberg
Gerard D. Schellenberg University of Pennsylvania

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