What is he best known for?
The fields of study he is best known for:
His main research concerns DNA, Stereochemistry, Crystallography, RNA and Biochemistry.
Aaron Klug has researched DNA in several fields, including G-Quartets and Zinc finger.
His Zinc finger research integrates issues from Peptide sequence, DNA binding site and Recombinant DNA.
The various areas that he examines in his Stereochemistry study include Hairpin ribozyme, Protein tertiary structure, Hammerhead ribozyme, Crystal structure and Hydrogen bond.
The study incorporates disciplines such as Chromatin, Nucleosome and Protein subunit in addition to Crystallography.
Aaron Klug combines topics linked to Virology with his work on RNA.
His most cited work include:
- Physical Principles in the Construction of Regular Viruses (1928 citations)
- Repetitive zinc‐binding domains in the protein transcription factor IIIA from Xenopus oocytes. (1715 citations)
- Reconstruction of Three Dimensional Structures from Electron Micrographs (1050 citations)
What are the main themes of his work throughout his whole career to date?
Aaron Klug mainly focuses on Crystallography, DNA, Tobacco mosaic virus, RNA and Zinc finger.
His Crystallography research includes themes of X-ray crystallography, Diffraction, Transfer RNA and Electron microscope.
He combines subjects such as DNA binding site and Stereochemistry with his study of DNA.
His research investigates the link between Tobacco mosaic virus and topics such as Protein structure that cross with problems in Peptide sequence.
His RNA research incorporates themes from Molecular biology and Transcription factor.
His research in Zinc finger intersects with topics in Binding site and DNA-binding protein.
He most often published in these fields:
- Crystallography (33.70%)
- DNA (19.89%)
- Tobacco mosaic virus (15.47%)
What were the highlights of his more recent work (between 1998-2010)?
- Zinc finger (14.36%)
- Computational biology (9.39%)
- Genetics (11.05%)
In recent papers he was focusing on the following fields of study:
Aaron Klug spends much of his time researching Zinc finger, Computational biology, Genetics, Gene and Cell biology.
His Zinc finger research includes elements of DNA and Mitochondrial DNA.
His DNA study frequently intersects with other fields, such as Regulation of gene expression.
His work on DNA-binding protein, Knockout rat and Mutant as part of general Genetics research is frequently linked to Chinese hamster ovary cell and Functional genomics, bridging the gap between disciplines.
His research integrates issues of RNA, Biophysics, Helix and General transcription factor in his study of Transcription factor.
His Coat protein study, which is part of a larger body of work in RNA, is frequently linked to Particle, bridging the gap between disciplines.
Between 1998 and 2010, his most popular works were:
- The Discovery of Zinc Fingers and Their Applications in Gene Regulation and Genome Manipulation (470 citations)
- Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases (379 citations)
- The tobacco mosaic virus particle: structure and assembly (350 citations)
In his most recent research, the most cited papers focused on:
Aaron Klug mostly deals with Zinc finger, Genetics, DNA, Zinc finger nuclease and Computational biology.
His work in Zinc finger tackles topics such as Mitochondrial DNA which are related to areas like Mitochondrion and Base pair.
His study in the field of Knockout rat, Mutant and Gene knockout also crosses realms of Chinese hamster ovary cell and Functional genomics.
His DNA study incorporates themes from Regulation of gene expression, Gene, Peptide sequence and Human genome.
His biological study spans a wide range of topics, including Protein–DNA interaction and RING finger domain.
His Computational biology research is multidisciplinary, relying on both Integrases and Effector.
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