Ross Jakes spends much of his time researching Tau protein, Cell biology, Biochemistry, Molecular biology and Alpha-synuclein. His Tau protein research includes themes of Amino acid, Peptide sequence and Hyperphosphorylation, Phosphorylation. His Biochemistry research integrates issues from Microtubule-associated protein, Beta-synuclein, Gamma-synuclein and Synuclein Family.
Ross Jakes has included themes like Enzyme activator, SB 203580 and Gene isoform in his Molecular biology study. His Alpha-synuclein research incorporates elements of Lewy body, Wild type, Mutant and Pathogenesis. His Lewy body study combines topics from a wide range of disciplines, such as Dementia with Lewy bodies and Glial cytoplasmic inclusion.
Ross Jakes mainly investigates Tau protein, Biochemistry, Molecular biology, Cell biology and Alpha-synuclein. His research in Tau protein intersects with topics in Epitope, Microtubule-associated protein and Phosphorylation. His study explores the link between Molecular biology and topics such as Peptide sequence that cross with problems in Complementary DNA and Sequence analysis.
His study looks at the intersection of Cell biology and topics like Anatomy with Biophysics and In vitro. His study in Alpha-synuclein is interdisciplinary in nature, drawing from both Lewy body and Dementia with Lewy bodies. His Beta-synuclein research incorporates themes from Gamma-synuclein, Synuclein Family and Glial cytoplasmic inclusion.
Ross Jakes mostly deals with Dementia with Lewy bodies, Tau protein, Molecular biology, Frontotemporal dementia and parkinsonism linked to chromosome 17 and Biochemistry. His work deals with themes such as Protein filament, Parkinson's disease, Alpha-synuclein and Cell biology, which intersect with Dementia with Lewy bodies. Alpha-synuclein is a primary field of his research addressed under Pathology.
His study focuses on the intersection of Tau protein and fields such as Gene isoform with connections in the field of Phosphorylation. His Frontotemporal dementia and parkinsonism linked to chromosome 17 study integrates concerns from other disciplines, such as Mutation, Microtubule-associated protein, Plasma protein binding and Genetics. When carried out as part of a general Biochemistry research project, his work on Neurite, Fibril, MAP2K7 and c-Raf is frequently linked to work in P70-S6 Kinase 1, therefore connecting diverse disciplines of study.
Ross Jakes focuses on Tauopathy, Fibril, Frontotemporal dementia and parkinsonism linked to chromosome 17, Tau protein and Biochemistry. The concepts of his Tauopathy study are interwoven with issues in Frontotemporal dementia, Mutation, Corticobasal degeneration, Parkinsonism and Neuroscience. Ross Jakes interconnects Crystallography, Random coil, Protein folding and Protein structure, Beta sheet in the investigation of issues within Fibril.
His study on Frontotemporal dementia and parkinsonism linked to chromosome 17 is covered under Neurodegeneration. His Tau protein study incorporates themes from Molecular biology, Colocalization and Gene isoform. His work carried out in the field of Biochemistry brings together such families of science as Dementia with Lewy bodies, Mutation and Cell biology.
Alpha-synuclein in Lewy bodies.
Maria Grazia Spillantini;Marie Luise Schmidt;Virginia M.-Y. Lee;John Q. Trojanowski.
Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease
M. Goedert;M.G. Spillantini;R. Jakes;D. Rutherford.
Identification of two distinct synucleins from human brain
Ross Jakes;Maria Grazia Spillantini;Michel Goedert.
FEBS Letters (1994)
Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans
M. Goedert;R. Jakes;M. G. Spillantini;M. G. Spillantini;M. Hasegawa.
Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease
C M Wischik;M Novak;H C Thøgersen;P C Edwards.
Proceedings of the National Academy of Sciences of the United States of America (1988)
Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding.
Gregory T. Bramblett;Michel Goedert;Ross Jakes;Sandra E. Merrick.
Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies
M G Spillantini;R A Crowther;R Jakes;N J Cairns.
Neuroscience Letters (1998)
Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization.
M. Goedert;R. Jakes.
The EMBO Journal (1990)
Abundant Tau Filaments and Nonapoptotic Neurodegeneration in Transgenic Mice Expressing Human P301S Tau Protein
Bridget Allen;Esther Ingram;Masaki Takao;Michael J. Smith.
The Journal of Neuroscience (2002)
Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation.
Poul H. Jensen;Morten S. Nielsen;Ross Jakes;Carlos G. Dotti.
Journal of Biological Chemistry (1998)
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