Benoit I. Giasson mainly investigates Alpha-synuclein, Pathology, Lewy body, Cell biology and Biochemistry. His work carried out in the field of Alpha-synuclein brings together such families of science as Protein structure, Immunoelectron microscopy, Cytoplasmic inclusion and Central nervous system. His Pathology research focuses on subjects like Mutation, which are linked to Immunology.
His studies in Lewy body integrate themes in fields like Alzheimer's disease, Dementia with Lewy bodies, Central nervous system disease and Synucleinopathies. He combines subjects such as Oxidative stress, Immunogold labelling and Wild type, Mutant with his study of Cell biology. His Biochemistry study combines topics in areas such as α synuclein and Pathogenesis.
His scientific interests lie mostly in Cell biology, Alpha-synuclein, Pathology, Synucleinopathies and Biochemistry. His Cell biology research includes elements of Fibril and Neurodegeneration, Tauopathy. His work is dedicated to discovering how Neurodegeneration, Neuroscience are connected with Parkinsonism and other disciplines.
His Alpha-synuclein study also includes
Benoit I. Giasson mostly deals with Cell biology, Tauopathy, Pathology, Neurodegeneration and Neuroscience. His Cell biology study focuses on Phosphorylation in particular. He interconnects Neuropil and Neurology in the investigation of issues within Pathology.
The study incorporates disciplines such as Lewy body and Senile plaques in addition to Neurodegeneration. His Lewy body study incorporates themes from Proteostasis and Amyloid. His Neuroscience research incorporates themes from Loss function and Disease.
Benoit I. Giasson mainly investigates Neurodegeneration, Lewy body, Phosphorylation, Pathology and Tauopathy. His study in Neurodegeneration is interdisciplinary in nature, drawing from both Neuroscience and Senile plaques. His Phosphorylation study introduces a deeper knowledge of Cell biology.
In his research, Inhibitory postsynaptic potential, Serine and In vivo is intimately related to Tau protein, which falls under the overarching field of Cell biology. He mostly deals with Synucleinopathies in his studies of Pathology. His Tauopathy research incorporates elements of Mutation, Protein aggregation, Parkinsonism and Frontotemporal dementia.
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Oxidative Damage Linked to Neurodegeneration by Selective α-Synuclein Nitration in Synucleinopathy Lesions
Benoit I. Giasson;John E. Duda;Ian V. J. Murray;Qiping Chen.
Neuronal α-Synucleinopathy with Severe Movement Disorder in Mice Expressing A53T Human α-Synuclein
Benoit I. Giasson;John E. Duda;John E. Duda;Shawn M. Quinn;Bin Zhang.
Initiation and synergistic fibrillization of tau and alpha-synuclein.
Benoit I. Giasson;Mark S. Forman;Mark S. Forman;Makoto Higuchi;Makoto Higuchi;Lawrence I. Golbe;Lawrence I. Golbe.
A Hydrophobic Stretch of 12 Amino Acid Residues in the Middle of α-Synuclein Is Essential for Filament Assembly
Benoit I. Giasson;Ian V.J. Murray;John Q. Trojanowski;Virginia M.-Y. Lee.
Journal of Biological Chemistry (2001)
Mutant and Wild Type Human α-Synucleins Assemble into Elongated Filaments with Distinct Morphologies in Vitro
Benoit I. Giasson;Kunihiro Uryu;John Q. Trojanowski;Virginia M.-Y Lee.
Journal of Biological Chemistry (1999)
Dityrosine cross-linking promotes formation of stable alpha -synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies.
José M. Souza;José M. Souza;Benoit I. Giasson;Qiping Chen;Virginia M.-Y. Lee.
Journal of Biological Chemistry (2000)
Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α‐synuclein
Pang‐hsien Tu;James E. Galvin;James E. Galvin;Minami Baba;Benoit Giasson.
Annals of Neurology (1998)
Lewy Bodies Contain Altered α-Synuclein in Brains of Many Familial Alzheimer's Disease Patients with Mutations in Presenilin and Amyloid Precursor Protein Genes
Carol F. Lippa;Hideo Fujiwara;David M.A. Mann;Benoit Giasson.
American Journal of Pathology (1998)
Induction of α-Synuclein Aggregation by Intracellular Nitrative Insult
Evgenia Paxinou;Qiping Chen;Marie Weisse;Benoit I. Giasson.
The Journal of Neuroscience (2001)
Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases
John E. Duda;Benoit I. Giasson;Meghann E. Mabon;Virginia M.-Y. Lee.
Annals of Neurology (2002)
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