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Biology and Biochemistry

D-Index
108
Citations
65879
World Ranking
1028
National Ranking
621

Overview

Harry Ischiropoulos is affiliated with the Children's Hospital of Philadelphia in the United States. Their research spans multiple disciplines within the biomedical sciences, focusing on areas such as medicine, biochemistry, genetics, and molecular biology.

The main fields of study covered by their work include:

  • Medicine (51 publications)
  • Biochemistry, Genetics and Molecular Biology (29 publications)

Within these fields, Ischiropoulos has contributed extensively to several subfields:

  • Molecular Biology (15 publications)
  • Physiology (14 publications)
  • Cardiology and Cardiovascular Medicine (10 publications)
  • Cellular and Molecular Neuroscience (6 publications)
  • Biochemistry (5 publications)

Their research topics highlight a focus on molecular and physiological processes, especially involving cardiovascular systems and cellular function:

  • Nitric Oxide and Endothelin Effects (14 publications)
  • Cardiovascular Function and Risk Factors (12 publications)
  • Mitochondrial Function and Pathology (10 publications)
  • Cardiovascular and exercise physiology (8 publications)
  • Neuroscience and Neuropharmacology Research (8 publications)
  • Amino Acid Enzymes and Metabolism (6 publications)
  • Caveolin-1 and cellular processes (6 publications)

Ischiropoulos's publications have appeared frequently in several scientific venues, with notable contributions in:

  • Circulation (3 publications)
  • Nitric Oxide (3 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (3 publications)
  • International Journal of Molecular Sciences (2 publications)
  • Redox Biology (2 publications)

Their recent papers include:

  • PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes, 2022, Cell Stem Cell
  • The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth, 2020, International Journal of Molecular Sciences
  • Systematic elucidation of neuron-astrocyte interaction in models of amyotrophic lateral sclerosis using multi-modal integrated bioinformatics workflow, 2020, Nature Communications
  • Human Placental Transcriptome Reveals Critical Alterations in Inflammation and Energy Metabolism with Fetal Sex Differences in Spontaneous Preterm Birth, 2021, International Journal of Molecular Sciences
  • Unveiling the human nitroproteome: Protein tyrosine nitration in cell signaling and cancer, 2023, Journal of Biological Chemistry

Throughout their career, Ischiropoulos has collaborated with multiple frequent co-authors, including:

  • Paschalis-Thomas Doulias (12 joint publications)
  • Hossein Fazelinia (8 joint publications)
  • Lynn A. Spruce (7 joint publications)
  • Hua Ding (6 joint publications)
  • Serena Raimo (5 joint publications)

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Evaluation of the probe 2',7'-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress.

    Carl P. LeBel;Harry Ischiropoulos;Stephen C. Bondy

  • Peroxynitrite: biochemistry, pathophysiology and development of therapeutics

    Csaba Szabó;Csaba Szabó;Harry Ischiropoulos;Rafael Radi

  • Oxidative Damage Linked to Neurodegeneration by Selective α-Synuclein Nitration in Synucleinopathy Lesions

    Benoit I. Giasson;John E. Duda;Ian V. J. Murray;Qiping Chen

  • Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase

    Harry Ischiropoulos;Ling Zhu;Jun Chen;Michael Tsai

  • Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations.

    Balaraman Kalyanaraman;Victor Darley-Usmar;Kelvin J.A. Davies;Phyllis A. Dennery

  • Biological tyrosine nitration: a pathophysiological function of nitric oxide and reactive oxygen species.

    Harry Ischiropoulos

  • Peroxynitrite formation from macrophage-derived nitric oxide

    Harry Ischiropoulos;Ling Zhu;Joseph S. Beckman

  • Blockade of Microglial Activation Is Neuroprotective in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model of Parkinson Disease

    Du Chu Wu;Vernice Jackson-Lewis;Miquel Vila;Kim Tieu

  • Evaluation of 2',7'-dichlorofluorescin and dihydrorhodamine 123 as fluorescent probes for intracellular H2O2 in cultured endothelial cells.

    J.A. Royall;H. Ischiropoulos

  • Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease

    Lemin Zheng;Benedicta Nukuna;Marie Luise Brennan;Mingjiang Sun

  • Oxidative stress and nitration in neurodegeneration: cause, effect, or association?

    Harry Ischiropoulos;Joseph S. Beckman

  • Kinetics of superoxide dismutase- and iron-catalyzed nitration of phenolics by peroxynitrite.

    Joseph S. Beckman;Harry Ischiropoulos;Ling Zhu;Mark van der Woerd

  • Peroxynitrite-mediated oxidation of dihydrorhodamine 123.

    Neil W. Kooy;James A. Royall;Harry Ischiropoulos;Joseph S. Beckman

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Dopamine-modified α-synuclein blocks chaperone-mediated autophagy

    Marta Martinez-Vicente;Zsolt Talloczy;Susmita Kaushik;Ashish C. Massey

  • Peroxynitrite-mediated oxidative protein modifications

    Harry Ischiropoulos;Abu B. Al-Mehdi

  • NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease

    Du-Chu Wu;Peter Teismann;Kim Tieu;Miquel Vila

  • Antimicrobial Actions of the Nadph Phagocyte Oxidase and Inducible Nitric Oxide Synthase in Experimental Salmonellosis. I. Effects on Microbial Killing by Activated Peritoneal Macrophages in Vitro

    Andrés Vazquez-Torres;Jessica Jones-Carson;Pietro Mastroeni;Harry Ischiropoulos

  • Biological selectivity and functional aspects of protein tyrosine nitration.

    Harry Ischiropoulos

Frequent Co-Authors

Benoit I. Giasson
Benoit I. Giasson University of Florida
Andrew J. Gow
Andrew J. Gow Rutgers, The State University of New Jersey
Virginia M.-Y. Lee
Virginia M.-Y. Lee University of Pennsylvania
Joseph S. Beckman
Joseph S. Beckman Oregon State University
John Q. Trojanowski
John Q. Trojanowski University of Pennsylvania
Serge Przedborski
Serge Przedborski Columbia University
Stanley L. Hazen
Stanley L. Hazen Cleveland Clinic Lerner College of Medicine
Kenneth B. Margulies
Kenneth B. Margulies University of Pennsylvania
Raymond R. Townsend
Raymond R. Townsend University of Pennsylvania
Csaba Szabó
Csaba Szabó University of Fribourg

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