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Molecular Biology

D-Index
70
Citations
19357
World Ranking
1414
National Ranking
720

Overview

Tom Ellenberger is affiliated with Washington University in St. Louis in the United States and works primarily within the fields of Biochemistry, Genetics, and Molecular Biology. Their research spans several subfields, including Molecular Biology, Oncology, Structural Biology, and Genetics.

The scientist's work addresses multiple topics, most notably DNA Repair Mechanisms and PARP inhibition in cancer therapy. Additional areas of focus include Advanced Electron Microscopy Techniques and Applications, DNA and Nucleic Acid Chemistry, and Bacterial Genetics and Biotechnology.

Recent publications reflect a focus on structural and molecular insights. These include:

  • An atypical BRCT-BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase IIIα within a flexible DNA repair complex, 2020, Nucleic Acids Research
  • Structure of an open conformation of T7 DNA polymerase reveals novel structural features regulating primer-template stabilization at the polymerization active site, 2021, Biochemical Journal

Collaboration is evident in Ellenberger's work, with frequent co-authors such as Michal Hammel, Ishtiaque Rashid, Aleksandr Sverzhinsky, Yasin Pourfarjam, and Miaw-Sheue Tsai. Their publications have appeared in venues like Nucleic Acids Research and the Biochemical Journal.

Best Publications

  • Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 Å resolution

    Sylvie Doublié;Stanley Tabor;Alexander M. Long;Charles C. Richardson

  • The GCN4 basic region leucine zipper binds DNA as a dimer of uninterrupted α Helices: Crystal structure of the protein-DNA complex

    Thomas E. Ellenberger;Christopher J. Brandl;Kevin Struhl;Stephen C. Harrison

  • Similarities and differences among 105 members of the Int family of site-specific recombinases

    Simone E. Nunes-Düby;Hyock Joo Kwon;Radhakrishna S. Tirumalai;Tom Ellenberger

  • DNA helicase Srs2 disrupts the Rad51 presynaptic filament

    Lumir Krejci;Stephen Van Komen;Ying Li;Jana Villemain

  • Mechanism of replication-coupled DNA interstrand crosslink repair.

    Markus Räschle;Puck Knipscheer;Milica Enoiu;Todor Angelov

  • Crystal structure of T7 gene 4 ring helicase indicates a mechanism for sequential hydrolysis of nucleotides.

    Martin R Singleton;Michael R Sawaya;Tom Ellenberger;Dale B Wigley

  • Folding transition in the DNA-binding domain of GCN4 on specific binding to DNA.

    M A Weiss;T Ellenberger;C R Wobbe;J P Lee

  • Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.

    Peter Cherepanov;Andre L. B. Ambrosio;Shaila Rahman;Tom Ellenberger

  • Human DNA ligase I completely encircles and partially unwinds nicked DNA.

    John M. Pascal;Patrick J. O'Brien;Patrick J. O'Brien;Alan E. Tomkinson;Tom Ellenberger

  • Eukaryotic DNA ligases: structural and functional insights.

    Tom Ellenberger;Alan E. Tomkinson

  • Dual DNA Binding Specificity of ADD1/SREBP1 Controlled by a Single Amino Acid in the Basic Helix-Loop-Helix Domain

    J. B. Kim;G. D. Spotts;Yuan-Di Halvorsen;Hsiu-Ming Shih

  • An open and closed case for all polymerases

    Sylvie Doublié;Michael R Sawaya;Tom Ellenberger

  • Single-Molecule Kinetics of λ Exonuclease Reveal Base Dependence and Dynamic Disorder

    Antoine M. van Oijen;Paul C. Blainey;Donald J. Crampton;Charles C. Richardson

  • Crystal structure of the helicase domain from the replicative helicase-primase of bacteriophage T7.

    Michael R. Sawaya;Shenyuan Guo;Stanley Tabor;Charles C. Richardson

  • Crystal structure of a human alkylbase-DNA repair enzyme complexed to DNA: Mechanisms for nucleotide flipping and base excision

    Albert Y. Lau;Orlando D. Schärer;Leona Samson;Gregory L. Verdine

  • DNA ligases: structure, reaction mechanism, and function.

    Alan E. Tomkinson;Sangeetha Vijayakumar;John M. Pascal;Tom Ellenberger

  • Structural Basis for the Excision Repair of Alkylation-Damaged DNA

    Jörg Labahn;Orlando D. Schärer;Alexander Long;Khosro Ezaz-Nikpay

  • Flexibility in DNA Recombination: Structure of the Lambda Integrase Catalytic Core

    Hyock Joo Kwon;Radhakrishna Tirumalai;Arthur Landy;Tom Ellenberger

  • Structure-based drug design and optimization of mannoside bacterial FimH antagonists.

    Zhenfu Han;Jerome S. Pinkner;Bradley Ford;Robert Obermann

  • Mechanism of Replication-Coupled DNA Interstrand Crosslink Repair (DOI:10.1016/j.cell.2008.08.030)

    Markus Räschle;Puck Knipscheer;Milica Enoiu;Todor Angelov

Frequent Co-Authors

John A. Tainer
John A. Tainer The University of Texas MD Anderson Cancer Center
Arthur Landy
Arthur Landy Brown University
Alan E. Tomkinson
Alan E. Tomkinson University of New Mexico
Charles C. Richardson
Charles C. Richardson Harvard University
Orlando D. Schärer
Orlando D. Schärer Institute for Basic Science
Gerhard Wagner
Gerhard Wagner Harvard University
Scott J. Hultgren
Scott J. Hultgren Washington University in St. Louis
Jack D. Griffith
Jack D. Griffith University of North Carolina at Chapel Hill
Michael G. Caparon
Michael G. Caparon Washington University in St. Louis
Danesh Moazed
Danesh Moazed Harvard University

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