World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
70
Citations
11574
World Ranking
7193
National Ranking
29

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Cancer
  • Enzyme

Jang Yang Chang mostly deals with Stereochemistry, Cancer research, Cancer, Cell culture and Biochemistry. His Stereochemistry study incorporates themes from IC50, In vitro, Chemical synthesis, Cytotoxicity and Combretastatin. His Cancer research research is multidisciplinary, incorporating elements of DNA damage, Carcinogenesis, Apoptosis, microRNA and Regulation of gene expression.

He is studying Cancer cell, which is a component of Cancer. His Cell culture research incorporates elements of Mitosis and Cell growth. The study of Biochemistry is intertwined with the study of Tubulin in a number of ways.

His most cited work include:

  • BPR0L075, a Novel Synthetic Indole Compound with Antimitotic Activity in Human Cancer Cells, Exerts Effective Antitumoral Activity in Vivo (174 citations)
  • BPR0L075, a Novel Synthetic Indole Compound with Antimitotic Activity in Human Cancer Cells, Exerts Effective Antitumoral Activity in Vivo (174 citations)
  • Concise synthesis and structure-activity relationships of combretastatin A-4 analogues, 1-aroylindoles and 3-aroylindoles, as novel classes of potent antitubulin agents. (147 citations)

What are the main themes of his work throughout his whole career to date?

His scientific interests lie mostly in Cancer research, Internal medicine, Cancer, Cancer cell and Stereochemistry. His studies in Cancer research integrate themes in fields like Cell growth, Carcinogenesis, Apoptosis, Downregulation and upregulation and microRNA. His research investigates the connection between Internal medicine and topics such as Oncology that intersect with problems in Chemotherapy.

Jang Yang Chang interconnects Cell and Cell biology in the investigation of issues within Cancer cell. His study in Stereochemistry is interdisciplinary in nature, drawing from both Cell culture, In vitro, Structure–activity relationship, Chemical synthesis and Combretastatin. His work carried out in the field of Cell culture brings together such families of science as Tubulin, Colchicine and Molecular biology.

He most often published in these fields:

  • Cancer research (50.00%)
  • Internal medicine (34.21%)
  • Cancer (29.74%)

What were the highlights of his more recent work (between 2016-2021)?

  • Cancer research (50.00%)
  • Internal medicine (34.21%)
  • Cancer (29.74%)

In recent papers he was focusing on the following fields of study:

His primary areas of investigation include Cancer research, Internal medicine, Cancer, Head and neck cancer and Cancer cell. His Cancer research research includes themes of Epithelial–mesenchymal transition, Carcinogenesis, Head and neck squamous-cell carcinoma, Transforming growth factor and Western blot. His research on Internal medicine frequently connects to adjacent areas such as Oncology.

The Cancer study combines topics in areas such as DNA damage, Angiogenesis, Drug resistance and Germline. The study incorporates disciplines such as Odds ratio, Alcohol, Confidence interval and Risk factor in addition to Head and neck cancer. His study looks at the relationship between Cancer cell and fields such as Cell, as well as how they intersect with chemical problems.

Between 2016 and 2021, his most popular works were:

  • New Insights into Mechanisms of Cisplatin Resistance: From Tumor Cell to Microenvironment. (57 citations)
  • New Insights into Mechanisms of Cisplatin Resistance: From Tumor Cell to Microenvironment. (57 citations)
  • Tumour cell-derived WNT5B modulates in vitro lymphangiogenesis via induction of partial endothelial-mesenchymal transition of lymphatic endothelial cells. (41 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Cancer
  • Enzyme

His primary areas of study are Cancer research, Carcinogenesis, Immunology, Cancer cell and microRNA. His Cancer research research integrates issues from Cancer, Colorectal cancer, Lymphangiogenesis, Signal transduction and Tube formation. His studies deal with areas such as DNA damage, Angiogenesis, Drug resistance and Cisplatin as well as Cancer.

His Immunology study integrates concerns from other disciplines, such as ALDH2, Oral Microbiome and Oral hygiene. His Cancer cell research includes elements of CDC42, Cell migration, A549 cell and Cell biology. His microRNA research is multidisciplinary, relying on both DNMT3B, Retinoic acid, ALDH1A2, Gene silencing and Epigenetics.

Best Publications

  • New Insights into Mechanisms of Cisplatin Resistance: From Tumor Cell to Microenvironment.

    Shang Hung Chen;Jang Yang Chang;Jang Yang Chang

  • BPR0L075, a Novel Synthetic Indole Compound with Antimitotic Activity in Human Cancer Cells, Exerts Effective Antitumoral Activity in Vivo

    Ching Chuan Kuo;Hsing Pang Hsieh;Wen Yu Pan;Ching Ping Chen

  • Concise synthesis and structure-activity relationships of combretastatin A-4 analogues, 1-aroylindoles and 3-aroylindoles, as novel classes of potent antitubulin agents.

    Jing Ping Liou;Yi Ling Chang;Fu Ming Kuo;Chun Wei Chang

  • Cytotoxic triterpenes from the aerial roots of Ficus microcarpa.

    Yi Ming Chiang;Jang-Yang Chang;Ching Chuan Kuo;Chi Yen Chang

  • Survivin - biology and potential as a therapeutic target in oncology.

    Chun Hei Antonio Cheung;Chien Chang Huang;Fang Ying Tsai;Jane Ying Chieh Lee

  • Novel Phosphoinositide 3-Kinase/mTOR Dual Inhibitor, NVP-BGT226, Displays Potent Growth-Inhibitory Activity against Human Head and Neck Cancer Cells In Vitro and In Vivo

    Kwang Yu Chang;Shan Yin Tsai;Ching Ming Wu;Chia Jui Yen

  • A KRAS mutation status-stratified randomized phase II trial of gemcitabine and oxaliplatin alone or in combination with cetuximab in advanced biliary tract cancer

    J.S. Chen;C. Hsu;N.J. Chiang;N.J. Chiang;N.J. Chiang;C.S. Tsai

  • 2,2'-Diphenyl-1-picrylhydrazyl radical-scavenging active components from adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) hulls.

    Ching Chuan Kuo;Wenchang Chiang;Guey Ping Liu;Ya Lin Chien

  • Downregulated miR329 and miR410 Promote the Proliferation and Invasion of Oral Squamous Cell Carcinoma by Targeting Wnt-7b

    Shine-Gwo Shiah;Shine-Gwo Shiah;Jenn-Ren Hsiao;Wei-Min Chang;Wei-Min Chang;Ya-Wen Chen

  • Epstein-Barr virus-associated gastric adenocarcinoma in Taiwan

    Horng Jyh Harn;Jang Yang Chang;Min Wei Wang;Li Ing Ho

  • Salvinal, a novel microtubule inhibitor isolated from Salvia miltiorrhizae Bunge (Danshen), with antimitotic activity in multidrug-sensitive and -resistant human tumor cells.

    Jang Yang Chang;Chi Yen Chang;Ching Chuan Kuo;Li Tzong Chen

  • Synthesis and structure-activity relationships of 3-aminobenzophenones as antimitotic agents

    Jing Ping Liou;Jang Yang Chang;Chun Wei Chang;Chi Yen Chang

  • Antitumor agents. 111. New 4-hydroxylated and 4-halogenated anilino derivatives of 4'-demethylepipodophyllotoxin as potent inhibitors of human DNA topoisomerase II.

    Kuo Hsiung Lee;Scott A. Beers;Masami Mori;Zhe Qing Wang

  • Aurora kinase inhibitors in preclinical and clinical testing

    Chun Hei Antonio Cheung;Mohane Selvaraj Coumar;Hsing Pang Hsieh;Jang Yang Chang

  • Mechanical regulation of cancer cell apoptosis and autophagy: roles of bone morphogenetic protein receptor, Smad1/5, and p38 MAPK.

    Sheng Chieh Lien;Shun Fu Chang;Pei Ling Lee;Shu Yi Wei

  • Phase I study of nanoliposomal irinotecan (PEP02) in advanced solid tumor patients.

    T. C. Chang;H. S. Shiah;C. H. Yang;K. H. Yeh

  • In vitro and in vivo studies of a novel potential anticancer agent of isochaihulactone on human lung cancer A549 cells

    Yi Lin Chen;Shinn Zong Lin;Jang Yang Chang;Yeung Leung Cheng

  • Characterization of camptothecin-resistant Chinese hamster lung cells.

    Jang Yang Chang;Lyle A. Dethlefsen;Lee R. Barley;Bing Sen Zhou

  • Recent Advances in Anti-Survivin Treatments for Cancer

    Rupinder K. Kanwar;C. H. Cheung;J. Y. Chang;Jagat R. Kanwar

  • Four New 6-Nor-5(6→7)abeo-abietane Type Diterpenes and Antitumoral Cytotoxic Diterpene Constituents from the Bark of Taiwania cryptomerioides

    Chi I. Chang;Jang Yang Chang;Ching Chuan Kuo;Wen Yu Pan

Frequent Co-Authors

Hsing-Pang Hsieh
Hsing-Pang Hsieh Academia Sinica
Yueh-Hsiung Kuo
Yueh-Hsiung Kuo China Medical University
Wu Chou Su
Wu Chou Su National Cheng Kung University
Ann-Lii Cheng
Ann-Lii Cheng National Taiwan University
Jacqueline Whang-Peng
Jacqueline Whang-Peng Taipei Medical University
Yung-Chi Cheng
Yung-Chi Cheng Yale University
Chun-Cheng Lin
Chun-Cheng Lin National Tsing Hua University
Michael Hsiao
Michael Hsiao Academia Sinica
Jagat R. Kanwar
Jagat R. Kanwar Deakin University
Ting-Chao Chou
Ting-Chao Chou Memorial Sloan Kettering Cancer Center

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