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Hsing-Pang Hsieh

Hsing-Pang Hsieh

D-Index & Metrics

Chemistry

D-Index
47
Citations
7119
World Ranking
15739
National Ranking
111

Overview

Hsing-Pang Hsieh is affiliated with Academia Sinica in Taiwan and has contributed to a range of studies primarily within the fields of Biochemistry, Genetics, and Molecular Biology, as well as Medicine.

Their research covers key subfields such as Molecular Biology, Organic Chemistry, Oncology, Infectious Diseases, and Cancer Research. This diverse disciplinary reach is reflected in the variety of topics addressed, including:

  • Cancer Mechanisms and Therapy
  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 Clinical Research Studies
  • Phagocytosis and Immune Regulation
  • Quinazolinone synthesis and applications
  • Cancer therapeutics and mechanisms
  • Traditional and Medicinal Uses of Annonaceae

Hsieh's publication record includes numerous peer-reviewed papers, with notable recent contributions such as:

  • "A critical overview of current progress for COVID-19: development of vaccines, antiviral drugs, and therapeutic antibodies" (2022) in the Journal of Biomedical Science
  • "Pharmacokinetics of anti-SARS-CoV agent niclosamide and its analogs in rats" (2020) in the Journal of Food and Drug Analysis
  • "Discovery of BPR1R024, an Orally Active and Selective CSF1R Inhibitor that Exhibits Antitumor and Immunomodulatory Activity in a Murine Colon Tumor Model" (2021) in the Journal of Medicinal Chemistry
  • "Identification of Entry Inhibitors against Delta and Omicron Variants of SARS-CoV-2" (2022) in the International Journal of Molecular Sciences
  • "Natural product myricetin is a pan-KDM4 inhibitor which with poly lactic-co-glycolic acid formulation effectively targets castration-resistant prostate cancer" (2022) in the Journal of Biomedical Science

Their frequent coauthors include Mu-Chun Li, Teng-Kuang Yeh, Chih-Ming Chen, Mohane Selvaraj Coumar, and Wan-Ching Yen, suggesting collaborative efforts across multiple projects.

Hsieh's work has been published most often in venues such as the Journal of Biomedical Science and the Journal of Medicinal Chemistry, each with five publications. Additional common publication venues include the European Journal of Medicinal Chemistry, Journal of the Chinese Chemical Society, and Bioorganic Chemistry.

Best Publications

  • BPR0L075, a Novel Synthetic Indole Compound with Antimitotic Activity in Human Cancer Cells, Exerts Effective Antitumoral Activity in Vivo

    Ching Chuan Kuo;Hsing Pang Hsieh;Wen Yu Pan;Ching Ping Chen

  • Inhibition of Severe Acute Respiratory Syndrome Coronavirus Replication by Niclosamide

    Chang Jer Wu;Jia Tsrong Jan;Chi Min Chen;Hsing Pang Hsieh

  • Inhibition of SARS-CoV 3C-like Protease Activity by Theaflavin-3,3'-digallate (TF3)

    Chia Nan Chen;Coney P.C. Lin;Kuo Kuei Huang;Wei Cheng Chen

  • Concise synthesis and structure-activity relationships of combretastatin A-4 analogues, 1-aroylindoles and 3-aroylindoles, as novel classes of potent antitubulin agents.

    Jing Ping Liou;Yi Ling Chang;Fu Ming Kuo;Chun Wei Chang

  • Pharmaceutical design of antimitotic agents based on combretastatins.

    H. P. Hsieh;J. P. Liou;N. Mahindroo

  • Structure-Based Drug Design and Structural Biology Study of Novel Nonpeptide Inhibitors of Severe Acute Respiratory Syndrome Coronavirus Main Protease

    I-Lin Lu;Neeraj Mahindroo;Po-Huang Liang;Yi-Hui Peng

  • Anti-influenza drug discovery: structure-activity relationship and mechanistic insight into novel angelicin derivatives.

    Jiann Yih Yeh;Mohane Selvaraj Coumar;Jim Tong Horng;Hui Yi Shiao;Hui Yi Shiao

  • Synthesis and structure-activity relationship of 2-aminobenzophenone derivatives as antimitotic agents.

    Jing Ping Liou;Chun Wei Chang;Jeng Shin Song;Yung Ning Yang

  • Synthesis and anti-viral activity of a series of sesquiterpene lactones and analogues in the subgenomic HCV replicon system.

    Der Ren Hwang;Yu Shan Wu;Chun Wei Chang;Tzu Wen Lien

  • Design and synthesis of tetrahydropyridothieno[2,3-d]pyrimidine scaffold based epidermal growth factor receptor (EGFR) kinase inhibitors: the role of side chain chirality and Michael acceptor group for maximal potency.

    Chia Hsien Wu;Mohane Selvaraj Coumar;Chang Ying Chu;Wen Hsing Lin

  • Protein Kinase Inhibitor Design by Targeting the Asp-Phe-Gly (DFG) Motif: The Role of the DFG Motif in the Design of Epidermal Growth Factor Receptor Inhibitors

    Yi Hui Peng;Hui Yi Shiao;Chih Hsiang Tu;Chih Hsiang Tu;Pang Min Liu

  • Strategies of Development of Antiviral Agents Directed Against Influenza Virus Replication

    Hsing Pang Hsieh;John T.A. Hsu;John T.A. Hsu

  • Structure-based drug design of a novel family of PPARgamma partial agonists: virtual screening, X-ray crystallography, and in vitro/in vivo biological activities.

    I-Lin Lu;Chien-Fu Huang;Yi-Hui Peng;Ying-Ting Lin

  • Synthesis and structure-activity relationships of 3-aminobenzophenones as antimitotic agents

    Jing Ping Liou;Jang Yang Chang;Chun Wei Chang;Chi Yen Chang

  • Evaluation of metal-conjugated compounds as inhibitors of 3CL protease of SARS-CoV

    John T.-A. Hsu;Chih-Jung Kuo;Hsing-Pang Hsieh;Yeau-Ching Wang

  • Novel indole-based peroxisome proliferator-activated receptor agonists: design, SAR, structural biology, and biological activities.

    Neeraj Mahindroo;Chien-Fu Huang;Yi-Huei Peng;Chiung-Chiu Wang

  • Synthesis and biological evaluation of 1-methyl-2-(3',4',5'-trimethoxybenzoyl)-3-aminoindoles as a new class of antimitotic agents and tubulin inhibitors.

    Romeo Romagnoli;Pier Giovanni Baraldi;Taradas Sarkar;Maria Dora Carrion

  • Thiopurine analogues inhibit papain-like protease of severe acute respiratory syndrome coronavirus

    Chi Yuan Chou;Chia Hui Chien;Yu San Han;Mojca Trstenjak Prebanda

  • Scaffold-hopping strategy: synthesis and biological evaluation of 5,6-fused bicyclic heteroaromatics to identify orally bioavailable anticancer agents.

    Yen Shih Tung;Yen Shih Tung;Mohane Selvaraj Coumar;Yu Shan Wu;Hui Yi Shiao

  • Synthesis and evaluation of 3-aroylindoles as anticancer agents: metabolite approach.

    Yu Shan Wu;Yu Shan Wu;Mohane Selvaraj Coumar;Jang Yang Chang;Hsu Yi Sun

  • 7-Aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents.

    Jang Yang Chang;Hsing Pang Hsieh;Chi Yen Chang;Kuo Shun Hsu

  • Structure-activity and crystallographic analysis of benzophenone derivatives - The potential anticancer agents

    Hsing Pang Hsieh;Jing Ping Liou;Ying Ting Lin;Neeraj Mahindroo

Frequent Co-Authors

Jang Yang Chang
Jang Yang Chang National Health Research Institutes
Shin-Ru Shih
Shin-Ru Shih Chang Gung University
Shui-Tein Chen
Shui-Tein Chen Academia Sinica
Chun-Cheng Lin
Chun-Cheng Lin National Tsing Hua University
Po-Huang Liang
Po-Huang Liang Academia Sinica
Gene-Hsiang Lee
Gene-Hsiang Lee National Taiwan University
Chuan-Liang Kao
Chuan-Liang Kao National Taiwan University
Hsing Jien Kung
Hsing Jien Kung Taipei Medical University
Cynthia J. Burrows
Cynthia J. Burrows University of Utah
Boris Turk
Boris Turk Jožef Stefan Institute

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