Po-Huang Liang

Overview

Best Publications

• Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus.

  Chih Chun Wen;Yueh Hsiung Kuo;Jia Tsrong Jan;Po Huang Liang

  622
  Citations

• Structure, mechanism and function of prenyltransferases

  Po-Huang Liang;Tzu-Ping Ko;Andrew H.-J Wang

  602
  Citations

• Small molecules targeting severe acute respiratory syndrome human coronavirus

  Chung Yi Wu;Jia Tsrong Jan;Shiou Hwa Ma;Chin Jung Kuo

  595
  Citations

• Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality.

  Dennis Lee;Scott A. Long;Jerry L. Adams;George Chan

  323
  Citations

• Ancestry of the 4-chlorobenzoate dehalogenase: analysis of amino acid sequence identities among families of acyl:adenyl ligases, enoyl-CoA hydratases/isomerases, and acyl-CoA thioesterases.

  Patricia C. Babbitt;George L. Kenyon;Brian M. Martin;Hugues Charest

  289
  Citations

• Mechanism of the Maturation Process of SARS-CoV 3CL Protease

  Min-Feng Hsu;Chih-Jung Kuo;Kai-Ti Chang;Kai-Ti Chang;Hui-Chuan Chang

  276
  Citations

• Inhibition of SARS-CoV 3C-like Protease Activity by Theaflavin-3,3'-digallate (TF3)

  Chia Nan Chen;Coney P.C. Lin;Kuo Kuei Huang;Wei Cheng Chen

  265
  Citations

• Structural and functional analysis of three β-glucosidases from bacterium Clostridium cellulovorans, fungus Trichoderma reesei and termite Neotermes koshunensis.

  Wen Yih Jeng;Nai Chen Wang;Man Hua Lin;Cheng Tse Lin

  234
  Citations

• Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases

  Rey Ting Guo;Rong Cao;Po Huang Liang;Po Huang Liang;Tzu Ping Ko

  230
  Citations

• Characterization of SARS main protease and inhibitor assay using a fluorogenic substrate

  Chih Jung Kuo;Ya Hui Chi;John T.A. Hsu;Po Huang Liang

  207
  Citations

• Structure-Based Drug Design and Structural Biology Study of Novel Nonpeptide Inhibitors of Severe Acute Respiratory Syndrome Coronavirus Main Protease

  I-Lin Lu;Neeraj Mahindroo;Po-Huang Liang;Yi-Hui Peng

  181
  Citations

• Structural Basis of Inhibition Specificities of 3C and 3C-like Proteases by Zinc-coordinating and Peptidomimetic Compounds

  Cheng Chung Lee;Cheng Chung Lee;Chih Jung Kuo;Tzu Ping Ko;Min Feng Hsu

  179
  Citations

• Loop closure and intersubunit communication in tryptophan synthase.

  Thomas R. Schneider;Eva Gerhardt;Minsu Lee;Po−Huang Liang

  178
  Citations

• Crystal Structures of Undecaprenyl Pyrophosphate Synthase in Complex with Magnesium, Isopentenyl Pyrophosphate, and Farnesyl Thiopyrophosphate ROLES OF THE METAL ION AND CONSERVED RESIDUES IN CATALYSIS

  Rey-Ting Guo;Tzu-Ping Ko;Annie P.-C. Chen;Annie P.-C. Chen;Chih-Jung Kuo

  176
  Citations

• Traditional Chinese medicine herbal extracts of Cibotium barometz, Gentiana scabra, Dioscorea batatas, Cassia tora, and Taxillus chinensis inhibit SARS-CoV replication.

  Chih-Chun Wen;Lie-Fen Shyur;Jia-Tsrong Jan;Po-Huang Liang

  172
  Citations

• Stable benzotriazole esters as mechanism-based inactivators of the severe acute respiratory syndrome 3CL protease.

  Chung-Yi Wu;Ke-Yung King;Chih-Jung Kuo;Jim-Min Fang;Jim-Min Fang

  154
  Citations

• Isolation and characterization of the three polypeptide components of 4-chlorobenzoate dehalogenase from Pseudomonas sp. strain CBS-3.

  Kai Hsuan Chang;Po Haung Liang;Wendie Beck;Jeffrey D. Scholten

  135
  Citations

• Anti-SARS coronavirus agents: a patent review (2008 – present)

  Vathan Kumar;Young-Sik Jung;Po-Huang Liang

  132
  Citations

• Synthesis and evaluation of pyrazolone compounds as SARS-coronavirus 3C-like protease inhibitors

  R. Ramajayam;Kian Pin Tan;Hun Ge Liu;Po Huang Liang;Po Huang Liang

  132
  Citations

• Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic alpha,beta-unsaturated esters.

  Jiun-Jie Shie;Jim-Min Fang;Jim-Min Fang;Tun-Hsun Kuo;Chih-Jung Kuo

  130
  Citations