2026 Andrew D. Mesecar: Biology and Biochemistry Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Chemistry	69	6164	5596	1875	1560	245	17714
Biology and Biochemistry	73	5941	5480	2812	2521	247	18887

Overview

Andrew D. Mesecar is affiliated with Purdue University West Lafayette in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a significant focus on Molecular Biology and Infectious Diseases, complemented by work in Computational Theory and Mathematics, Physiology, and Spectroscopy.

Key topics central to their research include:

SARS-CoV-2 and COVID-19 Research
Computational Drug Discovery Methods
COVID-19 Clinical Research Studies
Alzheimer's disease research and treatments
Protein Tyrosine Phosphatases
RNA modifications and cancer
Endoplasmic Reticulum Stress and Disease

Andrew D. Mesecar has contributed to numerous publications featured in various scientific venues. Frequent publication platforms include:

Zenodo (CERN European Organization for Nuclear Research)
bioRxiv (Cold Spring Harbor Laboratory)
Alzheimer's & Dementia
Biophysical Journal
UNC Libraries

Among recent papers authored or co-authored are:

"Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing", 2020, Nature
"Drug Development and Medicinal Chemistry Efforts toward SARS-Coronavirus and Covid-19 Therapeutics", 2020, ChemMedChem
"Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19", 2021, Nature Communications
"A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication", 2021, Nature Communications
"Discovery of a Novel Inhibitor of Coronavirus 3CL Protease for the Potential Treatment of COVID-19", 2020, bioRxiv (Cold Spring Harbor Laboratory)

Frequent co-authors involved in the research efforts alongside Andrew D. Mesecar include:

Emma K. Lendy
Karson S. Putt
Brent Clayton
Arun K. Ghosh
Ramya Visvanathan

Best Publications

The SARS-coronavirus papain-like protease: structure, function and inhibition by designed antiviral compounds.

Yahira M. Báez-Santos;Sarah E. St. John;Andrew D. Mesecar

859
Citations
Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing.

Laura Riva;Shuofeng Yuan;Xin Yin;Laura Martin-Sancho

783
Citations
The Papain-Like Protease of Severe Acute Respiratory Syndrome Coronavirus Has Deubiquitinating Activity

Naina Barretto;Dalia Jukneliene;Kiira M. Ratia;Zhongbin Chen

640
Citations
Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis.

Jill D. Dombrauckas;Bernard D. Santarsiero;Andrew D. Mesecar

582
Citations
Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2

Aimee L. Eggler;Guowen Liu;John M. Pezzuto;Richard B. van Breemen

553
Citations
A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication

Kiira Ratia;Scott Pegan;Jun Takayama;Katrina Sleeman

531
Citations
The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate.

Melissa S Jurica;Andrew Mesecar;Patrick J Heath;Wuxian Shi

513
Citations
Severe acute respiratory syndrome coronavirus papain-like protease: Structure of a viral deubiquitinating enzyme

Kiira Ratia;Kumar Singh Saikatendu;Bernard D. Santarsiero;Naina Barretto

462
Citations
Severe Acute Respiratory Syndrome Coronavirus Papain-Like Protease Ubiquitin-Like Domain and Catalytic Domain Regulate Antagonism of IRF3 and NF-κB Signaling

Matthew Frieman;Kiira M. Ratia;Robert E. Johnston;Andrew D. Mesecar

405
Citations
Phosphorylation of Serine 256 Suppresses Transactivation by FKHR (FOXO1) by Multiple Mechanisms DIRECT AND INDIRECT EFFECTS ON NUCLEAR/CYTOPLASMIC SHUTTLING AND DNA BINDING

Xiaohui Zhang;Lixia Gan;Haiyun Pan;Shaodong Guo

372
Citations
Deubiquitinating and Interferon Antagonism Activities of Coronavirus Papain-Like Proteases

Mark A. Clementz;Zhongbin Chen;Bridget S. Banach;Yanhua Wang

359
Citations
Modification of keap1 cysteine residues by sulforaphane.

Chenqi Hu;Aimee L. Eggler;Andrew D. Mesecar;Richard B. van Breemen

330
Citations
Molecular mechanisms of natural products in chemoprevention: induction of cytoprotective enzymes by Nrf2.

Aimee L. Eggler;Andrew D. Mesecar

309
Citations
Xanthohumol isolated from Humulus lupulus Inhibits menadione-induced DNA damage through induction of quinone reductase.

Birgit M. Dietz;Young Hwa Kang;Guowen Liu;Aimee L. Eggler

292
Citations
Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor.

Joanna E Burdette;Jianghua Liu;Shao-Nong Chen;Daniel S Fabricant

292
Citations
Drug Development and Medicinal Chemistry Efforts toward SARS-Coronavirus and Covid-19 Therapeutics.

Arun K. Ghosh;Margherita Brindisi;Margherita Brindisi;Dana Shahabi;Mackenzie E. Chapman

280
Citations
Orbital steering in the catalytic power of enzymes: small structural changes with large catalytic consequences.

Andrew D. Mesecar;Barry L. Stoddard;Daniel E. Koshland

278
Citations
Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19.

Britton Boras;Rhys M Jones;Brandon J Anson;Dan Arenson

272
Citations
New Chemical Constituents of Euphorbia quinquecostata and Absolute Configuration Assignment by a Convenient Mosher Ester Procedure Carried Out in NMR Tubes

Bao Ning Su;Eun Jung Park;Zakaria H. Mbwambo;Bernard D. Santarsiero

271
Citations
Silvestrol and episilvestrol, potential anticancer rocaglate derivatives from Aglaia silvestris.

Bang Yeon Hwang;Bao Ning Su;Heebyung Chai;Qiuwen Mi

267
Citations
X-ray Structural and Biological Evaluation of a Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-like Proteases

Yahira M. Báez-Santos;Scott J. Barraza;Michael W. Wilson;Michael P. Agius

240
Citations