What is he best known for?
The fields of study he is best known for:
His main research concerns Biochemistry, Protease, Ubiquitin, Stereochemistry and KEAP1.
His work is connected to Cysteine, Enzyme, In vitro, Binding site and Menadione, as a part of Biochemistry.
In his works, Andrew D. Mesecar conducts interdisciplinary research on Protease and Coronavirus.
His Ubiquitin study integrates concerns from other disciplines, such as Mutant and Cell biology.
His Stereochemistry research focuses on Stereoisomerism and how it relates to Thymidine and Alkaloid.
His study in Proteases is interdisciplinary in nature, drawing from both ISG15 and Virology.
His most cited work include:
- Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2 (340 citations)
- The Papain-Like Protease of Severe Acute Respiratory Syndrome Coronavirus Has Deubiquitinating Activity (339 citations)
- The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate. (331 citations)
What are the main themes of his work throughout his whole career to date?
His primary areas of investigation include Stereochemistry, Biochemistry, Protease, Coronavirus and Enzyme.
The concepts of his Stereochemistry study are interwoven with issues in Structure–activity relationship, Reductase, Pharmacognosy and Active site.
Biochemistry is represented through his Ubiquitin, KEAP1, Cysteine, In vitro and Mutant research.
In general Cysteine study, his work on Iodoacetamide often relates to the realm of Tandem mass spectrometry, thereby connecting several areas of interest.
Andrew D. Mesecar has included themes like Papain, Deubiquitinating enzyme, Vero cell and Peptidomimetic in his Protease study.
Andrew D. Mesecar integrates many fields, such as Coronavirus and engineering, in his works.
He most often published in these fields:
- Stereochemistry (37.56%)
- Biochemistry (36.04%)
- Protease (20.81%)
What were the highlights of his more recent work (between 2015-2021)?
- Coronavirus (19.80%)
- Virology (16.24%)
- Protease (20.81%)
In recent papers he was focusing on the following fields of study:
His primary areas of study are Coronavirus, Virology, Protease, Biochemistry and Enzyme.
His work on Porcine epidemic diarrhea virus and Viral protease as part of general Virology research is often related to Broad spectrum and Middle East respiratory syndrome coronavirus, thus linking different fields of science.
In his research on the topic of Protease, Prodrug and Indoline is strongly related with In vitro.
His Biochemistry research includes themes of Inflammation and Moiety.
His work deals with themes such as Crystallization, Stereochemistry and Drug discovery, which intersect with Enzyme.
His Proteases study combines topics in areas such as ISG15 and Enzyme kinetics.
Between 2015 and 2021, his most popular works were:
- Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing. (215 citations)
- Drug Development and Medicinal Chemistry Efforts toward SARS-Coronavirus and Covid-19 Therapeutics. (77 citations)
- Structural Insights into the Interaction of Coronavirus Papain-Like Proteases and Interferon-Stimulated Gene Product 15 from Different Species. (53 citations)
In his most recent research, the most cited papers focused on:
Coronavirus, Virology, Protease, Proteases and Computational biology are his primary areas of study.
Coronavirus is integrated with Papain, Polyproteins and Viral replication in his research.
Enzyme and Biochemistry are the areas that his Papain study falls under.
His work is dedicated to discovering how Protease, In vitro are connected with Viral life cycle and In vivo and other disciplines.
His research investigates the connection with Proteases and areas like ISG15 which intersect with concerns in Mutation, Mutant and Cell biology.
Andrew D. Mesecar focuses mostly in the field of Computational biology, narrowing it down to topics relating to Drug discovery and, in certain cases, Drug development, Proteolytic enzymes and Approved drug.
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