His main research concerns Biochemistry, Protease, Ubiquitin, Stereochemistry and KEAP1. His work is connected to Cysteine, Enzyme, In vitro, Binding site and Menadione, as a part of Biochemistry. In his works, Andrew D. Mesecar conducts interdisciplinary research on Protease and Coronavirus.
His Ubiquitin study integrates concerns from other disciplines, such as Mutant and Cell biology. His Stereochemistry research focuses on Stereoisomerism and how it relates to Thymidine and Alkaloid. His study in Proteases is interdisciplinary in nature, drawing from both ISG15 and Virology.
His primary areas of investigation include Stereochemistry, Biochemistry, Protease, Coronavirus and Enzyme. The concepts of his Stereochemistry study are interwoven with issues in Structure–activity relationship, Reductase, Pharmacognosy and Active site. Biochemistry is represented through his Ubiquitin, KEAP1, Cysteine, In vitro and Mutant research.
In general Cysteine study, his work on Iodoacetamide often relates to the realm of Tandem mass spectrometry, thereby connecting several areas of interest. Andrew D. Mesecar has included themes like Papain, Deubiquitinating enzyme, Vero cell and Peptidomimetic in his Protease study. Andrew D. Mesecar integrates many fields, such as Coronavirus and engineering, in his works.
His primary areas of study are Coronavirus, Virology, Protease, Biochemistry and Enzyme. His work on Porcine epidemic diarrhea virus and Viral protease as part of general Virology research is often related to Broad spectrum and Middle East respiratory syndrome coronavirus, thus linking different fields of science. In his research on the topic of Protease, Prodrug and Indoline is strongly related with In vitro.
His Biochemistry research includes themes of Inflammation and Moiety. His work deals with themes such as Crystallization, Stereochemistry and Drug discovery, which intersect with Enzyme. His Proteases study combines topics in areas such as ISG15 and Enzyme kinetics.
Coronavirus, Virology, Protease, Proteases and Computational biology are his primary areas of study. Coronavirus is integrated with Papain, Polyproteins and Viral replication in his research. Enzyme and Biochemistry are the areas that his Papain study falls under.
His work is dedicated to discovering how Protease, In vitro are connected with Viral life cycle and In vivo and other disciplines. His research investigates the connection with Proteases and areas like ISG15 which intersect with concerns in Mutation, Mutant and Cell biology. Andrew D. Mesecar focuses mostly in the field of Computational biology, narrowing it down to topics relating to Drug discovery and, in certain cases, Drug development, Proteolytic enzymes and Approved drug.
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Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2
Aimee L. Eggler;Guowen Liu;John M. Pezzuto;Richard B. van Breemen.
Proceedings of the National Academy of Sciences of the United States of America (2005)
The Papain-Like Protease of Severe Acute Respiratory Syndrome Coronavirus Has Deubiquitinating Activity
Naina Barretto;Dalia Jukneliene;Kiira M. Ratia;Zhongbin Chen.
Journal of Virology (2005)
Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis.
Jill D. Dombrauckas;Bernard D. Santarsiero;Andrew D. Mesecar.
The SARS-coronavirus papain-like protease: structure, function and inhibition by designed antiviral compounds.
Yahira M. Báez-Santos;Sarah E. St. John;Andrew D. Mesecar.
Antiviral Research (2015)
The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate.
Melissa S Jurica;Andrew Mesecar;Patrick J Heath;Wuxian Shi.
Severe acute respiratory syndrome coronavirus papain-like protease: Structure of a viral deubiquitinating enzyme
Kiira Ratia;Kumar Singh Saikatendu;Bernard D. Santarsiero;Naina Barretto.
Proceedings of the National Academy of Sciences of the United States of America (2006)
Phosphorylation of Serine 256 Suppresses Transactivation by FKHR (FOXO1) by Multiple Mechanisms DIRECT AND INDIRECT EFFECTS ON NUCLEAR/CYTOPLASMIC SHUTTLING AND DNA BINDING
Xiaohui Zhang;Lixia Gan;Haiyun Pan;Shaodong Guo.
Journal of Biological Chemistry (2002)
A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication
Kiira Ratia;Scott Pegan;Jun Takayama;Katrina Sleeman.
Proceedings of the National Academy of Sciences of the United States of America (2008)
Severe Acute Respiratory Syndrome Coronavirus Papain-Like Protease Ubiquitin-Like Domain and Catalytic Domain Regulate Antagonism of IRF3 and NF-κB Signaling
Matthew Frieman;Kiira M. Ratia;Robert E. Johnston;Andrew D. Mesecar.
Journal of Virology (2009)
Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor.
Joanna E Burdette;Jianghua Liu;Shao-Nong Chen;Daniel S Fabricant.
Journal of Agricultural and Food Chemistry (2003)
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