World's Best Scientists 2026 revealed!

D-Index & Metrics

Microbiology

D-Index
71
Citations
30608
World Ranking
1802
National Ranking
767

Research.com Recognitions

  • 2011 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Mark R. Denison is affiliated with Vanderbilt University Medical Center in the United States. Their research primarily focuses on medicine, with a significant emphasis on infectious diseases, molecular biology, epidemiology, animal science and zoology, and cardiology and cardiovascular medicine.

The scientist has contributed extensively to the study of viral pathogens, particularly SARS-CoV-2 and COVID-19, with their work spanning various related topics such as COVID-19 clinical research, respiratory viral infections, viral infections and immunology, viral gastroenteritis research, and hepatitis C virus research. The notable topics covered in their research include:

  • SARS-CoV-2 and COVID-19 Research
  • Viral gastroenteritis research and epidemiology
  • Animal Virus Infections Studies
  • COVID-19 Clinical Research Studies
  • Respiratory viral infections research
  • Viral Infections and Immunology Research
  • Hepatitis C virus research

The frequent collaborators of Mark R. Denison are Ralph S. Baric, Laura J. Stevens, Timothy P. Sheahan, Rachel L. Graham, and James D. Chappell, with the number of joint publications ranging from 20 to 33.

Denison's publications appear repeatedly in respected venues such as:

  • UNC Libraries
  • bioRxiv (Cold Spring Harbor Laboratory)
  • SSRN Electronic Journal
  • New England Journal of Medicine
  • Cell Reports

Representative recent papers include:

  • "An mRNA Vaccine against SARS-CoV-2 - Preliminary Report" (2020), published in the New England Journal of Medicine
  • "Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV" (2020), published in Nature Communications
  • "Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults" (2020), published in the New England Journal of Medicine
  • "SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness" (2020), published in Nature
  • "An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice" (2020), published in Science Translational Medicine

Their research contributions have been recognized with awards, including election as a Fellow of the American Association for the Advancement of Science (AAAS) in 2011.

Best Publications

  • An mRNA Vaccine against SARS-CoV-2 — Preliminary Report

    Lisa A. Jackson;Evan J. Anderson;Nadine G. Rouphael;Paul C. Roberts

  • Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV.

    Timothy P. Sheahan;Amy C. Sims;Sarah R. Leist;Alexandra Schäfer

  • Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

    Timothy P. Sheahan;Amy C. Sims;Rachel L. Graham;Vineet D. Menachery

  • SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness.

    Kizzmekia S. Corbett;Darin K. Edwards;Sarah R. Leist;Olubukola M. Abiona

  • Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults.

    Evan J. Anderson;Nadine G. Rouphael;Alicia T. Widge;Lisa A. Jackson

  • Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease

    Maria L. Agostini;Erica L. Andres;Amy C Sims;Rachel Lauren Graham

  • Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen

    Jesper Pallesen;Nianshuang Wang;Kizzmekia S. Corbett;Daniel Wrapp

  • An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice.

    Timothy P. Sheahan;Amy C. Sims;Shuntai Zhou;Rachel L. Graham

  • Durability of Responses after SARS-CoV-2 mRNA-1273 Vaccination.

    Alicia T. Widge;Nadine G. Rouphael;Lisa A. Jackson;Evan J. Anderson

  • Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus.

    I-Chueh Huang;Charles C. Bailey;Jessica L. Weyer;Sheli R. Radoshitzky

  • Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase

    Ariane J. Brown;John J. Won;Rachel L. Graham;Kenneth H. Dinnon

  • Coronaviruses: an RNA proofreading machine regulates replication fidelity and diversity.

    Mark R. Denison;Rachel L. Graham;Eric F. Donaldson;Lance D. Eckerle

  • Coronavirus Replication Complex Formation Utilizes Components of Cellular Autophagy

    Erik Prentice;W. Gray Jerome;Tamotsu Yoshimori;Noboru Mizushima

  • Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice.

    Andrea J. Pruijssers;Andrea J. Pruijssers;Amelia S. George;Amelia S. George;Alexandra Schäfer;Sarah R. Leist

  • Middle East Respiratory Syndrome

    Yaseen M. Arabi;Hanan H. Balkhy;Frederick G. Hayden;Abderrezak Bouchama

  • Infidelity of SARS-CoV Nsp14-exonuclease mutant virus replication is revealed by complete genome sequencing.

    Lance D. Eckerle;Michelle M. Becker;Rebecca A. Halpin;Kelvin Li

  • Coronaviruses Lacking Exoribonuclease Activity Are Susceptible to Lethal Mutagenesis: Evidence for Proofreading and Potential Therapeutics

    Everett Clinton Smith;Hervé Blanc;Marco Vignuzzi;Mark R. Denison

  • Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus

    Boyd Yount;Kristopher M. Curtis;Elizabeth A. Fritz;Lisa E. Hensley

  • Systematic Assembly of a Full-Length Infectious cDNA of Mouse Hepatitis Virus Strain A59

    Boyd Yount;Mark R. Denison;Susan R. Weiss;Ralph S. Baric

  • High Fidelity of Murine Hepatitis Virus Replication Is Decreased in nsp14 Exoribonuclease Mutants

    Lance D. Eckerle;Xiaotao Lu;Steven M. Sperry;Leena Choi

  • Identification and Characterization of Severe Acute Respiratory Syndrome Coronavirus Replicase Proteins

    Erik Prentice;Josephine McAuliffe;Xiaotao Lu;Kanta Subbarao

Frequent Co-Authors

Ralph S. Baric
Ralph S. Baric University of North Carolina at Chapel Hill
James D. Chappell
James D. Chappell Vanderbilt University Medical Center
Amy C. Sims
Amy C. Sims University of North Carolina at Chapel Hill
Timothy P. Sheahan
Timothy P. Sheahan University of North Carolina at Chapel Hill
Susan R. Weiss
Susan R. Weiss University of Pennsylvania
Boyd Yount
Boyd Yount University of North Carolina at Chapel Hill
Barney S. Graham
Barney S. Graham Morehouse School of Medicine
Kizzmekia S. Corbett
Kizzmekia S. Corbett Harvard University
Tomas Cihlar
Tomas Cihlar Gilead Sciences (United States)
Alexandra Schäfer
Alexandra Schäfer Duke University

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