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D-Index & Metrics

Biology and Biochemistry

D-Index
68
Citations
25062
World Ranking
7640
National Ranking
3477

Overview

Tomas Cihlar is affiliated with Gilead Sciences, located in the United States, and their research primarily focuses on medicine with significant contributions in infectious diseases, epidemiology, virology, cardiology and cardiovascular medicine, and hepatology.

The scientist's recent publications include work on antiviral therapies and viral infections, particularly targeting viruses such as MERS-CoV and SARS-CoV-2. Key papers are:

  • Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV (2020, Nature Communications)
  • Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection (2020, Proceedings of the National Academy of Sciences)
  • Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2 (2020, Nature)
  • Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice (2020, Cell Reports)
  • Clinical targeting of HIV capsid protein with a long-acting small molecule (2020, Nature)

Tomas Cihlar has frequently collaborated with several co-authors, including:

  • John P. Bilello
  • Danielle Porter
  • Darius Babusis
  • Joy Y. Feng
  • Timothy P. Sheahan

The scientist's work has been published often in prominent venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • UNC Libraries
  • Nature Communications
  • Antimicrobial Agents and Chemotherapy
  • Antiviral Research

Their research topics mainly revolve around viral infections and treatment development, covering:

  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 Clinical Research Studies
  • Respiratory viral infections research
  • Viral Infections and Outbreaks Research
  • HIV Research and Treatment
  • HIV/AIDS drug development and treatment
  • Viral gastroenteritis research and epidemiology

Best Publications

  • Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV.

    Timothy P. Sheahan;Amy C. Sims;Sarah R. Leist;Alexandra Schäfer

  • Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

    Timothy P. Sheahan;Amy C. Sims;Rachel L. Graham;Vineet D. Menachery

  • Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

    Travis K. Warren;Robert Jordan;Michael K. Lo;Adrian S. Ray

  • Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease

    Maria L. Agostini;Erica L. Andres;Amy C Sims;Rachel Lauren Graham

  • Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection.

    Emmie de Wit;Friederike Feldmann;Jacqueline Cronin;Robert Jordan

  • Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2.

    Brandi N. Williamson;Friederike Feldmann;Benjamin Schwarz;Kimberly Meade-White

  • Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses

    Dustin Siegel;Hon C. Hui;Edward Doerffler;Michael O. Clarke

  • Assessment of Mitochondrial Toxicity in Human Cells Treated with Tenofovir: Comparison with Other Nucleoside Reverse Transcriptase Inhibitors

    Gabriel Birkus;Michael J. M. Hitchcock;Tomas Cihlar

  • Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase

    Ariane J. Brown;John J. Won;Rachel L. Graham;Kenneth H. Dinnon

  • GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses.

    Michael K. Lo;Robert Jordan;Aaron Arvey;Jawahar Sudhamsu

  • Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice.

    Andrea J. Pruijssers;Andrea J. Pruijssers;Amelia S. George;Amelia S. George;Alexandra Schäfer;Sarah R. Leist

  • Nucleoside and nucleotide HIV reverse transcriptase inhibitors: 25 years after zidovudine

    Tomas Cihlar;Adrian S. Ray

  • Cytotoxicity of Antiviral Nucleotides Adefovir and Cidofovir Is Induced by the Expression of Human Renal Organic Anion Transporter 1

    Edmund S. Ho;Deborah C. Lin;Dirk B. Mendel;Tomas Cihlar

  • Selective Intracellular Activation of a Novel Prodrug of the Human Immunodeficiency Virus Reverse Transcriptase Inhibitor Tenofovir Leads to Preferential Distribution and Accumulation in Lymphatic Tissue

    William A. Lee;Gong-Xin He;Eugene Eisenberg;Tomas Cihlar

  • Mechanism of Active Renal Tubular Efflux of Tenofovir

    Adrian S. Ray;Tomas Cihlar;Kelly L. Robinson;Leah Tong

  • Clinical targeting of HIV capsid protein with a long-acting small molecule.

    John O. Link;Martin S. Rhee;Winston C. Tse;Jim Zheng

  • Histone deacetylase inhibitor romidepsin induces HIV expression in CD4 T cells from patients on suppressive antiretroviral therapy at concentrations achieved by clinical dosing.

    Datsen George Wei;Vicki Chiang;Elizabeth Fyne;Mini Balakrishnan

  • Current status and challenges of antiretroviral research and therapy.

    José A. Esté;Tomas Cihlar

  • Human renal organic anion transporter 1 (hOAT1) and its role in the nephrotoxicity of antiviral nucleotide analogs

    Tomas Cihlar;Edmund S. Ho;Deborah C. Lin;Andrew S. Mulato

  • Antiviral Activity of Bictegravir (GS-9883), a Novel Potent HIV-1 Integrase Strand Transfer Inhibitor with an Improved Resistance Profile

    Manuel Tsiang;Gregg S. Jones;Joshua Goldsmith;Andrew Mulato

Frequent Co-Authors

Adrian S. Ray
Adrian S. Ray Yale University
Choung U. Kim
Choung U. Kim Bristol-Myers Squibb (Germany)
Ralph S. Baric
Ralph S. Baric University of North Carolina at Chapel Hill
Timothy P. Sheahan
Timothy P. Sheahan University of North Carolina at Chapel Hill
Mark R. Denison
Mark R. Denison Vanderbilt University Medical Center
Sina Bavari
Sina Bavari United States Army Medical Research Institute of Infectious Diseases
Amy C. Sims
Amy C. Sims University of North Carolina at Chapel Hill
David R. Martinez
David R. Martinez Yale University
Emmie de Wit
Emmie de Wit National Institutes of Health
James D. Chappell
James D. Chappell Vanderbilt University Medical Center

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