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Immunology

D-Index
131
Citations
68882
World Ranking
221
National Ranking
145

Medicine

D-Index
131
Citations
69257
World Ranking
2385
National Ranking
1345

Research.com Recognitions

  • 2019 - Member of the National Academy of Medicine (NAM)
  • 2018 - Presidential Award, Clinical Immunology Society
  • 2006 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Gynaecology and Paediatrics

Overview

Luigi D. Notarangelo is affiliated with the National Institutes of Health in the United States. Their research spans multiple fields within medicine, immunology, and molecular biology, with a significant focus on the immunological aspects of infectious diseases. Their expertise includes immunodeficiency, autoimmune disorders, immune cell function, and SARS-CoV-2 and COVID-19 research.

The scientist has contributed extensively to the literature, with publications primarily in:

  • Journal of Clinical Immunology
  • Clinical Immunology
  • Journal of Allergy and Clinical Immunology
  • Frontiers in Immunology
  • bioRxiv (Cold Spring Harbor Laboratory)

Major areas of study include:

  • Medicine
  • Immunology and Microbiology
  • Biochemistry, Genetics and Molecular Biology

Within these broader disciplines, Notarangelo's work is categorized further into subfields such as:

  • Immunology
  • Infectious Diseases
  • Genetics
  • Molecular Biology
  • Epidemiology

The main research topics for Notarangelo cover:

  • Immunodeficiency and Autoimmune Disorders
  • Immune Cell Function and Interaction
  • SARS-CoV-2 and COVID-19 Research
  • T-cell and B-cell Immunology
  • COVID-19 Clinical Research Studies
  • Blood disorders and treatments
  • Cytomegalovirus and herpesvirus research

Among their most cited recent papers are:

  • "Autoantibodies against type I IFNs in patients with life-threatening COVID-19," 2020, published in Science
  • "X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19," 2021, Science Immunology
  • "Human genetic and immunological determinants of critical COVID-19 pneumonia," 2022, Nature
  • "An immune-based biomarker signature is associated with mortality in COVID-19 patients," 2020, JCI Insight
  • "Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1," 2021, The Journal of Experimental Medicine

Frequent collaborators include:

  • Ottavia M. Delmonte
  • Marita Bosticardo
  • Kerry Dobbs
  • Helen C. Su
  • Steven M. Holland

Luigi D. Notarangelo has been recognized through several awards, including:

  • Member of the National Academy of Medicine (NAM), 2019
  • Presidential Award, Clinical Immunology Society, 2018
  • German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina - Nationale Akademie der Wissenschaften, 2006 (in Gynaecology and Paediatrics)

Best Publications

  • Autoantibodies against type I IFNs in patients with life-threatening COVID-19.

    Paul Bastard;Paul Bastard;Paul Bastard;Lindsey B. Rosen;Qian Zhang;Eleftherios Michailidis

  • Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

    Qian Zhang;Paul Bastard;Paul Bastard;Zhiyong Liu;Jérémie Le Pen

  • Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2).

    Patrick Revy;Taro Muto;Yves Levy;Frédéric Geissmann

  • Diagnostic criteria for primary immunodeficiencies. Representing PAGID (Pan-American Group for Immunodeficiency) and ESID (European Society for Immunodeficiencies).

    Mary Ellen Conley;Luigi D. Notarangelo;Amos Etzioni

  • Gene Therapy for Immunodeficiency Due to Adenosine Deaminase Deficiency

    Alessandro Aiuti;Federica Cattaneo;Stefania Galimberti;Ulrike Benninghoff

  • The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM

    J. Sayos;C. Wu;M. Morra;N. Wang

  • Gene therapy in peripheral blood lymphocytes and bone marrow for ADA- immunodeficient patients

    Claudio Bordignon;Luigi D. Notarangelo;Nadia Nobili;Giuliana Ferrari

  • Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4

    Hye Sun Kuehn;Weiming Ouyang;Bernice Lo;Elissa K. Deenick;Elissa K. Deenick

  • Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM

    Ulf Korthäuer;Daniel Graf;Hans W. Mages;Francine Brière

  • B cell–helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen

    Irene Puga;Montserrat Cols;Carolina M. Barra;Bing-Yang He

  • Defects in TCIRG1 subunit of the vacuolar proton pump are responsible for a subset of human autosomal recessive osteopetrosis.

    Annalisa Frattini;Paul J. Orchard;Cristina Sobacchi;Silvia Giliani

  • Transplantation Outcomes for Severe Combined Immunodeficiency, 2000–2009

    Sung Yun Pai;Brent R. Logan;Linda M. Griffith;Rebecca H. Buckley

  • Clinical spectrum of X-linked hyper-IgM syndrome

    Jacov Levy;Teresa Espanol-Boren;Carolin Thomas;Alain Fischer

  • Newborn Screening for Severe Combined Immunodeficiency in 11 Screening Programs in the United States

    Antonia Kwan;Roshini S. Abraham;Robert Currier;Amy Brower

  • Expansion of the Human Phenotype Ontology (HPO) knowledge base and resources

    Sebastian Köhler;Leigh Carmody;Nicole A. Vasilevsky;Julius O. B. Jacobsen

  • X-Linked Lymphoproliferative Disease 2b4 Molecules Displaying Inhibitory Rather than Activating Function Are Responsible for the Inability of Natural Killer Cells to Kill Epstein-Barr Virus–Infected Cells

    Silvia Parolini;Cristina Bottino;Michela Falco;Raffaella Augugliaro

  • Primary Immunodeficiency Diseases: An Update on the Classification from the International Union of Immunological Societies Expert Committee for Primary Immunodeficiency

    Waleed Al-Herz;Aziz Bousfiha;Jean-Laurent Casanova;Jean-Laurent Casanova;Helen Chapel

  • Primary immunodeficiencies: 2009 update

    Luigi D. Notarangelo;Alain Fischer;Raif S. Geha;Jean-Laurent Casanova

  • Primary immunodeficiency diseases: An update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee

    Raif S. Geha;Luigi D. Notarangelo;Jean Laurent Casanova;Helen Chapel

  • A three-dimensional model of human lung development and disease from pluripotent stem cells

    Ya-Wen Chen;Sarah Xuelian Huang;Ana Luisa Rodrigues Toste de Carvalho;Siu-Hong Ho

  • Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation

    Xianqin Zhang;Dusan Bogunovic;Béatrice Payelle-Brogard;Véronique Francois-Newton

Frequent Co-Authors

Silvia Giliani
Silvia Giliani University of Brescia
Jolan E. Walter
Jolan E. Walter University of South Florida
Sung-Yun Pai
Sung-Yun Pai National Institutes of Health
Anna Villa
Anna Villa National Academies of Sciences, Engineering, and Medicine
Jean-Laurent Casanova
Jean-Laurent Casanova The University of Texas Southwestern Medical Center
Raif S. Geha
Raif S. Geha Boston Children's Hospital
Laurent Abel
Laurent Abel Université Paris Cité
Shen-Ying Zhang
Shen-Ying Zhang Rockefeller University
Waleed Al-Herz
Waleed Al-Herz Kuwait University
Jennifer M. Puck
Jennifer M. Puck University of California, San Francisco

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