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Immunology

D-Index
72
Citations
21097
World Ranking
2200
National Ranking
1065

Overview

Shen-Ying Zhang is a researcher affiliated with Rockefeller University in the United States. Their work spans multiple domains within biomedical science, focusing extensively on immunology, infectious diseases, and molecular biology. With a publication record encompassing 140 works in Medicine, 80 in Immunology and Microbiology, and 62 in Biochemistry, Genetics, and Molecular Biology, their contributions cover diverse aspects of human health and disease.

Their primary research interests include Immunodeficiency and Autoimmune Disorders, interferon and immune responses, and SARS-CoV-2 and COVID-19 research. Additional topics of study include COVID-19 clinical research, RNA regulation and disease, Kawasaki Disease and coronary complications, and blood disorders and treatments.

Notable recent publications by Shen-Ying Zhang include:

  • "Autoantibodies against type I IFNs in patients with life-threatening COVID-19," 2020, Science
  • "X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19," 2021, Science Immunology
  • "Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1," 2021, The Journal of Experimental Medicine
  • "A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection," 2020, Cell
  • "Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine," 2021, The Journal of Experimental Medicine

Frequent publication venues for Zhang include The Journal of Experimental Medicine (16 publications), bioRxiv (Cold Spring Harbor Laboratory) (10), Journal of Clinical Immunology (9), Current Opinion in Immunology (5), and Science Immunology (4).

Shen-Ying Zhang collaborates regularly with several well-known scientists in the field. Their frequent co-authors include Jean-Laurent Casanova, Paul Bastard, Laurent Abel, Qian Zhang, and Emmanuelle Jouanguy. These collaborations reflect a strong network focused on immunology and infectious diseases research.

Best Publications

  • Autoantibodies against type I IFNs in patients with life-threatening COVID-19.

    Paul Bastard;Paul Bastard;Paul Bastard;Lindsey B. Rosen;Qian Zhang;Eleftherios Michailidis

  • Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

    Qian Zhang;Paul Bastard;Paul Bastard;Zhiyong Liu;Jérémie Le Pen

  • Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors.

    Jérôme Cros;Nicolas Cagnard;Kevin Woollard;Natacha Patey

  • TLR3 deficiency in patients with herpes simplex encephalitis.

    Shen Ying Zhang;Shen Ying Zhang;Emmanuelle Jouanguy;Emmanuelle Jouanguy;Sophie Ugolini;Asma Smahi

  • Herpes simplex virus encephalitis in human UNC-93B deficiency.

    Armanda Casrouge;Shen Ying Zhang;Shen Ying Zhang;Céline Eidenschenk;Emmanuelle Jouanguy;Emmanuelle Jouanguy

  • Autoantibodies neutralizing type I IFNs are present in ~ 4% of uninfected individuals over 70 years old and account for ~ 20% of COVID-19 deaths.

    Paul Bastard;Adrian Gervais;Adrian Gervais;Tom Le Voyer;Tom Le Voyer;Jérémie Rosain;Jérémie Rosain

  • Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation

    Xianqin Zhang;Dusan Bogunovic;Béatrice Payelle-Brogard;Véronique Francois-Newton

  • Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency

    Michael J. Ciancanelli;Sarah X.L. Huang;Priya Luthra;Hannah Garner

  • Selective predisposition to bacterial infections in IRAK-4–deficient children: IRAK-4–dependent TLRs are otherwise redundant in protective immunity

    Cheng Lung Ku;Horst Von Bernuth;Horst Von Bernuth;Capucine Picard;Shen Ying Zhang

  • Inborn errors of interferon (IFN)-mediated immunity in humans: insights into the respective roles of IFN-alpha/beta, IFN-gamma, and IFN-lambda in host defense.

    Shen-Ying Zhang;Stéphanie Boisson-Dupuis;Stéphanie Boisson-Dupuis;Ariane Chapgier;Ariane Chapgier;Kun Yang;Kun Yang

  • X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19.

    Takaki Asano;Bertrand Boisson;Bertrand Boisson;Bertrand Boisson;Fanny Onodi;Daniela Matuozzo;Daniela Matuozzo

  • Human TRAF3 Adaptor Molecule Deficiency Leads to Impaired Toll-like Receptor 3 Response and Susceptibility to Herpes Simplex Encephalitis

    Rebeca Pérez de Diego;Rebeca Pérez de Diego;Rebeca Pérez de Diego;Vanessa Sancho-Shimizu;Vanessa Sancho-Shimizu;Vanessa Sancho-Shimizu;Lazaro Lorenzo;Lazaro Lorenzo;Lazaro Lorenzo;Anne Puel;Anne Puel;Anne Puel

  • Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells

    Fabien G Lafaille;Itai M. Pessach;Itai M. Pessach;Shen-Ying Zhang;Shen-Ying Zhang;Michael J. Ciancanelli

  • Human TLR-7-, -8-, and -9-Mediated Induction of IFN-α/β and -λ Is IRAK-4 Dependent and Redundant for Protective Immunity to Viruses

    Kun Yang;Kun Yang;Anne Puel;Shenying Zhang;Shenying Zhang;Céline Eidenschenk

  • Heterozygous TBK1 mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood

    Melina Herman;Michael Ciancanelli;Yi Hung Ou;Lazaro Lorenzo

  • Parsing the Interferon Transcriptional Network and Its Disease Associations

    Sara Mostafavi;Sara Mostafavi;Hideyuki Yoshida;Devapregasan Moodley;Hugo LeBoité

  • The mutation significance cutoff: gene-level thresholds for variant predictions

    Yuval Itan;Lei Shang;Bertrand Boisson;Bertrand Boisson;Michael J Ciancanelli

  • Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency

    Vanessa Sancho-Shimizu;Rebeca Pérez de Diego;Lazaro Lorenzo;Rabih Halwani

  • Herpes simplex virus encephalitis in a patient with complete TLR3 deficiency: TLR3 is otherwise redundant in protective immunity

    Yiqi Guo;Yiqi Guo;Magali Audry;Michael Ciancanelli;Laia Alsina;Laia Alsina

  • The human gene damage index as a gene-level approach to prioritizing exome variants

    Yuval Itan;Lei Shang;Bertrand Boisson;Etienne Patin;Etienne Patin

  • Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1.

    Paul Bastard;Paul Bastard;Paul Bastard;Elizaveta Orlova;Leila Sozaeva;Romain Lévy;Romain Lévy

  • IRAK-4-and MyD88-Dependent Pathways Are Essential for the Removal of Developing Autoreactive B Cells in Humans

    Isabelle Isnardi;Yen Shing Ng;Iva Srdanovic;Roja Motaghedi

Frequent Co-Authors

Laurent Abel
Laurent Abel Université Paris Cité
Jean-Laurent Casanova
Jean-Laurent Casanova The University of Texas Southwestern Medical Center
Emmanuelle Jouanguy
Emmanuelle Jouanguy Necker-Enfants Malades Hospital
Bertrand Boisson
Bertrand Boisson Rockefeller University
Aurélie Cobat
Aurélie Cobat Grenoble Alpes University
Stéphanie Boisson-Dupuis
Stéphanie Boisson-Dupuis Université Paris Cité
Capucine Picard
Capucine Picard Université Paris Cité
Jacinta Bustamante
Jacinta Bustamante Rockefeller University
Yuval Itan
Yuval Itan Icahn School of Medicine at Mount Sinai

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