The scientist’s investigation covers issues in Receptor, Cell biology, Tumor necrosis factor alpha, Molecular biology and Signal transduction. His Receptor study integrates concerns from other disciplines, such as Extracellular and Cytokine. His Cell biology study combines topics in areas such as Cancer research and Apoptosis, Caspase, Programmed cell death, Fas receptor.
His work carried out in the field of Tumor necrosis factor alpha brings together such families of science as In vitro and Recombinant DNA. His Molecular biology research incorporates elements of NFKB1, Interferon, Messenger RNA, MHC Class I Gene and Caspase 10. The Signal transduction study combines topics in areas such as Transcription factor and Kinase.
His main research concerns Tumor necrosis factor alpha, Molecular biology, Receptor, Cell biology and Immunology. His research in Tumor necrosis factor alpha intersects with topics in Cancer research and Cytokine. The various areas that he examines in his Molecular biology study include Interferon, Cytotoxic T cell and Antibody, Monoclonal antibody, Polyclonal antibodies.
His studies in Interferon integrate themes in fields like Virus, Vesicular stomatitis virus and Peripheral blood mononuclear cell, In vitro. His Receptor research incorporates themes from Extracellular, Intracellular and Function. In his study, Inflammation is strongly linked to Caspase 8, which falls under the umbrella field of Cell biology.
David Wallach focuses on Cell biology, Caspase 8, Tumor necrosis factor alpha, Programmed cell death and Immunology. His Cell biology research includes elements of Inflammation, Apoptosis and Necroptosis. His study looks at the intersection of Caspase 8 and topics like Cancer research with Transcription and Genetic enhancement.
His work deals with themes such as Receptor, Cytokine and Molecular biology, which intersect with Tumor necrosis factor alpha. His work in Receptor tackles topics such as Immune system which are related to areas like Cytotoxic T cell. His Molecular biology research is multidisciplinary, incorporating elements of Peptide sequence and Transgene.
His scientific interests lie mostly in Cell biology, Programmed cell death, Immunology, Apoptosis and Caspase 8. His Cell biology study incorporates themes from Receptor and RIPK1, Necroptosis. His Receptor research incorporates themes from Immune system and Pathogenesis.
Tumor necrosis factor alpha and IκB kinase are subfields of Immunology in which his conducts study. His Apoptosis study integrates concerns from other disciplines, such as Progenitor cell, Molecular biology and Transcriptional regulation. His work carried out in the field of Signal transduction brings together such families of science as Fas receptor and Cell.
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Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death.
Mark P Boldin;Tanya M Goncharov;Yury V Goltseve;David Wallach.
Cell (1996)
MAP3K-related kinase involved in NF- K B induction by TNF, CD95 and IL-1
Nikolai L. Malinin;Mark P. Boldin;Andrei V. Kovalenko;David Wallach.
Nature (1997)
TUMOR NECROSIS FACTOR RECEPTOR AND Fas SIGNALING MECHANISMS
D. Wallach;E. E. Varfolomeev;N. L. Malinin;Yuri V. Goltsev.
Annual Review of Immunology (1999)
Targeted Disruption of the Mouse Caspase 8 Gene Ablates Cell Death Induction by the TNF Receptors, Fas/Apo1, and DR3 and Is Lethal Prenatally
Eugene E Varfolomeev;Marcus Schuchmann;Victor Luria;Nuchanard Chiannilkulchai.
Immunity (1998)
The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination.
Andrew Kovalenko;Christine Chable-Bessia;Giuseppina Cantarella;Giuseppina Cantarella;Alain Israël.
Nature (2003)
A NOVEL PROTEIN THAT INTERACTS WITH THE DEATH DOMAIN OF FAS/APO1 CONTAINS A SEQUENCE MOTIF RELATED TO THE DEATH DOMAIN
Mark P. Boldin;Eugene E. Varfolomeev;Zeev Pancer;Igor L. Mett.
Journal of Biological Chemistry (1995)
Stabilization of the bioactivity of tumor necrosis factor by its soluble receptors.
D Aderka;H Engelmann;Y Maor;C Brakebusch.
Journal of Experimental Medicine (1992)
Two tumor necrosis factor-binding proteins purified from human urine. Evidence for immunological cross-reactivity with cell surface tumor necrosis factor receptors.
H Engelmann;D Novick;D Wallach.
Journal of Biological Chemistry (1990)
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
Lorenzo Galluzzi;Ilio Vitale;Stuart A. Aaronson;John M. Abrams.
Nature (2018)
A tumor necrosis factor-binding protein purified to homogeneity from human urine protects cells from tumor necrosis factor toxicity.
H Engelmann;D Aderka;M Rubinstein;D Rotman.
Journal of Biological Chemistry (1989)
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