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Immunology

D-Index
70
Citations
18428
World Ranking
2408
National Ranking
15

Overview

Zelig Eshhar is affiliated with the Weizmann Institute of Science in Israel and has a research focus spanning medicine and immunology and microbiology. Their publications emphasize the intersection of oncology, immunology, and biomedical engineering, with a particular specialization in CAR-T cell therapy research.

The scientist's work broadly covers the following main fields of study:

  • Medicine
  • Immunology and Microbiology

Subfields include:

  • Oncology
  • Immunology
  • Biomedical Engineering
  • Molecular Biology
  • Radiology, Nuclear Medicine and Imaging

Key topics addressed in their research consist of:

  • CAR-T cell therapy research
  • Immunotherapy and Immune Responses
  • Immune Cell Function and Interaction
  • Nanowire Synthesis and Applications
  • Monoclonal and Polyclonal Antibodies Research
  • Viral Infectious Diseases and Gene Expression in Insects
  • 3D Printing in Biomedical Research

Zelig Eshhar has published in several scientific venues, including:

  • Cancer Letters
  • European Journal of Immunology
  • Nature Communications
  • Cancer Immunology Research
  • The Journal of Immunology

Some of their recent papers include:

  • Trastuzumab derived HER2-specific CARs for the treatment of trastuzumab-resistant breast cancer: CAR T cells penetrate and eradicate tumors that are not accessible to antibodies (2020, Cancer Letters)
  • CAR T cells: Building on the CD19 paradigm (2021, European Journal of Immunology)
  • P32-specific CAR T cells with dual antitumor and antiangiogenic therapeutic potential in gliomas (2021, Nature Communications)
  • Treatment of Multiple Myeloma Using Chimeric Antigen Receptor T Cells with Dual Specificity (2020, Cancer Immunology Research)
  • T Cells Retain Pivotal Antitumoral Functions under Tumor-Treating Electric Fields (2021, The Journal of Immunology)

Zelig Eshhar has collaborated frequently with other researchers. Regular coauthors include:

  • Anat Globerson Levin
  • Tova Waks
  • Galit Horn
  • Tamar Shiloach
  • Árpád Szöőr

This research record reflects extensive involvement in advancing various dimensions of immunotherapy, CAR-T design, and tumor immunology. The integration of biomedical engineering techniques is evident in their multidisciplinary approach.

Best Publications

  • Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors.

    Zelig Eshhar;Tova Waks;Gideon Gross;Daniel G. Schindler

  • Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificity

    Gideon Gross;Tova Waks;Zelig Eshhar

  • A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer

    Michael H. Kershaw;Michael H. Kershaw;Michael H. Kershaw;Jennifer A. Westwood;Jennifer A. Westwood;Linda L. Parker;Gang Wang;Gang Wang

  • In Vivo Antitumor Activity of T Cells Redirected with Chimeric Antibody/T-Cell Receptor Genes

    Patrick Hwu;J. C. Yang;R. Cowherd;J. Treisman

  • A herceptin-based chimeric antigen receptor with modified signaling domains leads to enhanced survival of transduced T lymphocytes and antitumor activity.

    Yangbing Zhao;Qiong J. Wang;Shicheng Yang;James N. Kochenderfer

  • Lysis of ovarian cancer cells by human lymphocytes redirected with a chimeric gene composed of an antibody variable region and the Fc receptor gamma chain.

    P Hwu;G E Shafer;J Treisman;D G Schindler

  • Detection of a cytokeratin determinant common to diverse epithelial cells by a broadly cross-reacting monoclonal antibody

    O. Gigi;B. Geiger;Z. Eshhar;R. Moll

  • Suppression of Murine Colitis and its Associated Cancer by Carcinoembryonic Antigen-Specific Regulatory T Cells

    Dan Blat;Ehud Zigmond;Ehud Zigmond;Zoya Alteber;Tova Waks

  • Targeting of T lymphocytes to Neu/HER2-expressing cells using chimeric single chain Fv receptors.

    I Stancovski;D G Schindler;T Waks;Y Yarden

  • Monoclonal antibodies against receptor for epidermal growth factor induce early and delayed effects of epidermal growth factor.

    Alain B. Schreiber;Irit Lax;Yosef Yarden;Zelig Eshhar

  • Grafting primary human T lymphocytes with cancer-specific chimeric single chain and two chain TCR

    R A Willemsen;M E M Weijtens;C Ronteltap;Z Eshhar

  • Functional expression of chimeric receptor genes in human T cells.

    Zelig Eshhar;Tova Waks;Alain Bendavid;Daniel G Schindler

  • Redirection of Regulatory T Cells With Predetermined Specificity for the Treatment of Experimental Colitis in Mice

    Eran Elinav;Tova Waks;Zelig Eshhar

  • catELISA: a facile general route to catalytic antibodies.

    Dan S. Tawfik;Bernard S. Green;Rachel Chap;Michael Sela

  • Amelioration of Colitis by Genetically Engineered Murine Regulatory T Cells Redirected by Antigen-Specific Chimeric Receptor

    Eran Elinav;Nitzan Adam;Tova Waks;Zelig Eshhar

  • Inhibition of IgE binding to mast cells and basophils by monoclonal antibodies to murine IgE.

    Michal Baniyash;Zelig Eshhar

  • Generation of effector T cells expressing chimeric T cell receptor with antibody type-specificity.

    G Gross;G Gorochov;T Waks;Z Eshhar

  • Tumor-specific T-bodies: towards clinical application

    Zelig Eshhar

  • Chimeric receptor genes and cells transformed therewith

    Zelig Eshhar;Daniel Schindler;Tova Waks;Gideon Gross

  • Therapeutic Potential of T Cell Chimeric Antigen Receptors (CARs) in Cancer Treatment: Counteracting Off-Tumor Toxicities for Safe CAR T Cell Therapy

    Gideon Gross;Gideon Gross;Zelig Eshhar;Zelig Eshhar

  • Lymphoid cell surface interaction structures detected using cytolysis-inhibiting monoclonal antibodies.

    Pierre Golstein;Christo Goridis;Anne-Marie Schmitt-Verhulst;Brigitte Hayot

Frequent Co-Authors

Dan S. Tawfik
Dan S. Tawfik Weizmann Institute of Science
David Wallach
David Wallach Weizmann Institute of Science
Eran Elinav
Eran Elinav Weizmann Institute of Science
Daniela Novick
Daniela Novick Weizmann Institute of Science
Michael Sela
Michael Sela Weizmann Institute of Science
Avi Orr-Urtreger
Avi Orr-Urtreger Tel Aviv University
Menachem Rubinstein
Menachem Rubinstein Weizmann Institute of Science
Edna Mozes
Edna Mozes Weizmann Institute of Science
Michel Revel
Michel Revel Weizmann Institute of Science
Yoram Reiter
Yoram Reiter Technion – Israel Institute of Technology

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