Andreas Hombach

Overview

Best Publications

• Tumor-specific T cell activation by recombinant immunoreceptors: CD3 zeta signaling and CD28 costimulation are simultaneously required for efficient IL-2 secretion and can be integrated into one combined CD28/CD3 zeta signaling receptor molecule.

  Andreas Hombach;Anja Wieczarkowiecz;Thomas Marquardt;Claudia Heuser

  434
  Citations

• T Cell Activation by Antibody-Like Immunoreceptors: Increase in Affinity of the Single-Chain Fragment Domain above Threshold Does Not Increase T Cell Activation against Antigen-Positive Target Cells but Decreases Selectivity

  Markus Chmielewski;Andreas Hombach;Claudia Heuser;Gregory P. Adams

  359
  Citations

• Adoptive immunotherapy with genetically engineered T cells: modification of the IgG1 Fc 'spacer' domain in the extracellular moiety of chimeric antigen receptors avoids 'off-target' activation and unintended initiation of an innate immune response.

  A Hombach;A A Hombach;H Abken

  297
  Citations

• Epstein Barr virus–specific cytotoxic T lymphocytes expressing the anti-CD30ζ artificial chimeric T-cell receptor for immunotherapy of Hodgkin disease

  Barbara Savoldo;Cliona M. Rooney;Cliona M. Rooney;Antonio Di Stasi;Hinrich Abken

  286
  Citations

• Chronic inflammatory bowel disease and cancer

  C Pohl;A Hombach;W Kruis

  219
  Citations

• Antigen-Specific T-Cell Activation Independently of the MHC: Chimeric Antigen Receptor-Redirected T Cells.

  Markus Chmielewski;Andreas A. Hombach;Hinrich Abken

  208
  Citations

• T cells that target carcinoembryonic antigen eradicate orthotopic pancreatic carcinomas without inducing autoimmune colitis in mice.

  Markus Chmielewski;Olga Hahn;Gunter Rappl;Michael Nowak

  190
  Citations

• T-cell activation by recombinant receptors: CD28 costimulation is required for interleukin 2 secretion and receptor-mediated T-cell proliferation but does not affect receptor-mediated target cell lysis.

  Andreas Hombach;Dagmar Sent;Claudia Schneider;Claudia Heuser

  169
  Citations

• Eradication of melanomas by targeted elimination of a minor subset of tumor cells

  Patrick Schmidt;Caroline Kopecky;Andreas Hombach;Paola Zigrino

  163
  Citations

• Transfer of mRNA encoding recombinant immunoreceptors reprograms CD4+ and CD8+ T cells for use in the adoptive immunotherapy of cancer

  K Birkholz;A Hombach;C Krug;S Reuter

  156
  Citations

• Chimeric Antigen Receptors for T-Cell Based Therapy

  Eleanor J. Cheadle;Vicky Sheard;Andreas A. Hombach;Markus Chmielewski

  156
  Citations

• Building Better Chimeric Antigen Receptors for Adoptive T Cell Therapy

  John S. Bridgeman;Robert E. Hawkins;Andreas A. Hombach;Hinrich Abken

  155
  Citations

• Rational development of high-affinity T-cell receptor-like antibodies

  Guillaume Stewart-Jones;Andreas Wadle;Anja Hombach;Eugene Shenderov

  154
  Citations

• A chimeric receptor that selectively targets membrane-bound carcinoembryonic antigen (mCEA) in the presence of soluble CEA.

  A Hombach;D Koch;R Sircar;C Heuser

  154
  Citations

• Arming Cytokine-induced Killer Cells With Chimeric Antigen Receptors: CD28 Outperforms Combined CD28–OX40 “Super-stimulation”

  Andreas A Hombach;Gunter Rappl;Hinrich Abken

  147
  Citations

• An anti-CD30 chimeric receptor that mediates CD3-zeta-independent T-cell activation against Hodgkin's lymphoma cells in the presence of soluble CD30.

  Andreas Hombach;Claudia Heuser;Ranjan Sircar;Thorsten Tillmann

  147
  Citations

• T Cell Activation by Antibody-Like Immunoreceptors: The Position of the Binding Epitope within the Target Molecule Determines the Efficiency of Activation of Redirected T Cells

  Andreas A. Hombach;Verena Schildgen;Claudia Heuser;Ricarda Finnern

  140
  Citations

• CD28 costimulation Impairs the efficacy of a redirected t-cell antitumor attack in the presence of regulatory t cells which can be overcome by preventing Lck activation.

  David M Kofler;Markus Chmielewski;Gunter Rappl;Anja Hombach

  140
  Citations

• Tuning tumor-specific T-cell activation: a matter of costimulation?

  Hinrich Abken;Andreas Hombach;Claudia Heuser;Kai Kronfeld

  117
  Citations

• CD28 Costimulation Overcomes Transforming Growth Factor-β–Mediated Repression of Proliferation of Redirected Human CD4+ and CD8+ T Cells in an Antitumor Cell Attack

  Heike Koehler;David Kofler;Andreas Hombach;Hinrich Abken

  117
  Citations