World's Best Scientists 2026 revealed!

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Immunology

D-Index
119
Citations
74630
World Ranking
337
National Ranking
212

Medicine

D-Index
121
Citations
75458
World Ranking
3544
National Ranking
1953

Overview

Michel Sadelain is affiliated with Columbia University in the United States, focusing on research in medicine, immunology, and molecular biology. Their work spans several important subfields, including oncology, immunology, molecular biology, electrical and electronic engineering, and genetics.

The core of their research revolves around CAR-T cell therapy, a specialized form of immunotherapy involving genetically engineered T cells designed to target cancer cells. This area is prominently represented with 196 publications, alongside studies on immune cell function and interaction, viral infectious diseases, gene expression in insects, immunotherapy, immune responses, CRISPR and genetic engineering, as well as advancements in semiconductor devices, circuit design, biosimilars, and bioanalytical methods.

Michel Sadelain has contributed notably to various research publications, including the following recent papers:

  • Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer, 2023, Nature
  • Senolytic CAR T cells reverse senescence-associated pathologies, 2020, Nature
  • Cytokine release syndrome and associated neurotoxicity in cancer immunotherapy, 2021, Nature Reviews Immunology
  • A Phase I Trial of Regional Mesothelin-Targeted CAR T-cell Therapy in Patients with Malignant Pleural Disease, in Combination with the Anti-PD-1 Agent Pembrolizumab, 2021, Cancer Discovery
  • Gut microbiome correlates of response and toxicity following anti-CD19 CAR T cell therapy, 2022, Nature Medicine

Their frequent co-authors consist of researchers with whom they have collaborated extensively:

  • Isabelle Rivière (41 publications)
  • Jorge Mansilla-Soto (32 publications)
  • Jae H. Park (26 publications)
  • Renier J. Brentjens (22 publications)
  • Judith Feucht (20 publications)

Michel Sadelain's work appears regularly in several leading publication venues. Those include:

  • Blood (25 publications)
  • Cancer Research (9 publications)
  • Nature Medicine (7 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (7 publications)
  • Nature (6 publications)

Best Publications

  • Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

    Stuart M Chambers;Christopher A. Fasano;Eirini P. Papapetrou;Mark J. Tomishima

  • Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia

    Marco L. Davila;Isabelle Riviere;Xiuyan Wang;Shirley Bartido

  • Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia

    Jae H. Park;Isabelle Rivière;Mithat Gonen;Xiuyan Wang

  • Chimeric Antigen Receptor Therapy.

    Carl H. June;Michel Sadelain

  • CD19-Targeted T Cells Rapidly Induce Molecular Remissions in Adults with Chemotherapy-Refractory Acute Lymphoblastic Leukemia

    Renier J. Brentjens;Marco L. Davila;Isabelle Riviere;Jae Park

  • The Basic Principles of Chimeric Antigen Receptor Design

    Michel Sadelain;Renier Brentjens;Isabelle Rivière

  • Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection

    Justin Eyquem;Jorge Mansilla-Soto;Theodoros Giavridis;Sjoukje J. C. van der Stegen

  • Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias

    Renier J. Brentjens;Isabelle Rivière;Jae H. Park;Marco L. Davila

  • Gene therapy comes of age.

    Cynthia E. Dunbar;Katherine A. High;J. Keith Joung;Donald B. Kohn

  • Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer

    Unknown

  • Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRzeta /CD28 receptor.

    John Maher;Renier J Brentjens;Gertrude Gunset;Isabelle Rivière

  • CAR T cell-induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade.

    Theodoros Giavridis;Sjoukje J. C. van der Stegen;Justin Eyquem;Mohamad Hamieh

  • Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs

    Gabsang Lee;Eirini P. Papapetrou;Hyesoo Kim;Stuart M. Chambers

  • Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis

    Glenn Dranoff;Alexander D. Crawford;Michel Sadelain;Beverly Ream

  • Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition

    Leonid Cherkassky;Aurore Morello;Jonathan Villena-Vargas;Yang Feng

  • Therapeutic T cell engineering

    Michel Sadelain;Isabelle Rivière;Stanley Riddell

  • Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15.

    Renier J. Brentjens;Jean Baptiste Latouche;Elmer Santos;Francesc Marti

  • Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells

    Christopher C Kloss;Maud Condomines;Marc Cartellieri;Michael Bachmann

  • PD-1– and CTLA-4–Based Inhibitory Chimeric Antigen Receptors (iCARs) Divert Off-Target Immunotherapy Responses

    Victor D. Fedorov;Maria Themeli;Michel Sadelain

  • Senolytic CAR T cells reverse senescence-associated pathologies.

    Corina Amor;Judith Feucht;Josef Leibold;Yu-Jui Ho

  • Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning

    Hollie J. Pegram;James C. Lee;Erik G. Hayman;Gavin H. Imperato

  • The promise and potential pitfalls of chimeric antigen receptors

    Michel Sadelain;Renier Brentjens;Isabelle Rivière

Frequent Co-Authors

Isabelle Riviere
Isabelle Riviere Memorial Sloan Kettering Cancer Center
Renier J. Brentjens
Renier J. Brentjens Roswell Park Cancer Institute
Richard J. O'Reilly
Richard J. O'Reilly Memorial Sloan Kettering Cancer Center
Steven M. Larson
Steven M. Larson Memorial Sloan Kettering Cancer Center
Stefano Rivella
Stefano Rivella Children's Hospital of Philadelphia
Marcel R.M. van den Brink
Marcel R.M. van den Brink Memorial Sloan Kettering Cancer Center
Donald B. Kohn
Donald B. Kohn University of California, Los Angeles
Ronald G. Blasberg
Ronald G. Blasberg Memorial Sloan Kettering Cancer Center
Miguel-Angel Perales
Miguel-Angel Perales Memorial Sloan Kettering Cancer Center
Valerie W. Rusch
Valerie W. Rusch Memorial Sloan Kettering Cancer Center

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