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Immunology

D-Index
81
Citations
27286
World Ranking
1546
National Ranking
773

Overview

Barbara Savoldo is affiliated with the University of North Carolina at Chapel Hill in the United States. Their primary research focus lies within the field of Medicine, with a specialization in Oncology, Immunology, Genetics, Molecular Biology, and Pathology and Forensic Medicine.

The main topics of their research include:

  • CAR-T cell therapy research
  • Immune Cell Function and Interaction
  • Lymphoma Diagnosis and Treatment
  • Virus-based gene therapy research
  • Nanowire Synthesis and Applications
  • Viral Infectious Diseases and Gene Expression in Insects
  • T-cell and B-cell Immunology

Barbara Savoldo has contributed to several notable publications, including:

  • Anti-CD30 CAR-T Cell Therapy in Relapsed and Refractory Hodgkin Lymphoma, 2020, Journal of Clinical Oncology
  • Immunogenicity of CAR T cells in cancer therapy, 2021, Nature Reviews Clinical Oncology
  • Scalable Manufacturing of CAR T Cells for Cancer Immunotherapy, 2021, Blood Cancer Discovery
  • Anti-GD2 CAR-NKT cells in patients with relapsed or refractory neuroblastoma: an interim analysis, 2020, Nature Medicine
  • Interleukin-23 engineering improves CAR T cell function in solid tumors, 2020, Nature Biotechnology

The scientist has frequently collaborated with a select group of coauthors, including:

  • Gianpietro Dotti
  • Natalie S. Grover
  • Jonathan S. Serody
  • Catherine Cheng
  • Elisa Landoni

The prominent venues where Barbara Savoldo's work has been published are:

  • UNC Libraries
  • Blood
  • Nature Cancer
  • Clinical Cancer Research
  • Journal for ImmunoTherapy of Cancer

Best Publications

  • Inducible apoptosis as a safety switch for adoptive cell therapy

    Antonio Di Stasi;Siok Keen Tey;Gianpietro Dotti;Yuriko Fujita

  • Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma

    Martin A. Pule;Barbara Savoldo;G. Doug Myers;G. Doug Myers;Claudia Rossig

  • Antitumor activity and long-term fate of chimeric antigen receptor–positive T cells in patients with neuroblastoma

    Chrystal U. Louis;Chrystal U. Louis;Barbara Savoldo;Barbara Savoldo;Gianpietro Dotti;Gianpietro Dotti;Martin Pule

  • CD28 costimulation improves expansion and persistence of chimeric antigen receptor–modified T cells in lymphoma patients

    Barbara Savoldo;Carlos Almeida Ramos;Carlos Almeida Ramos;Enli Liu;Martha P. Mims

  • Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15

    Yang Xu;Ming Zhang;Carlos A. Ramos;April Durett

  • Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T-lymphocytes

    Ignazio Caruana;Barbara Savoldo;Valentina Hoyos;Gerrit Weber

  • Cord blood NK cells engineered to express IL-15 and a CD19-targeted CAR show long-term persistence and potent antitumor activity

    Enli Liu;Yijiu Tong;Gianpietro Dotti;Hila Shaim

  • Design and development of therapies using chimeric antigen receptor-expressing T cells

    Gianpietro Dotti;Stephen Gottschalk;Barbara Savoldo;Malcolm K. Brenner

  • Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma/leukemia effects and safety

    Valentina Hoyos;Barbara Savoldo;Barbara Savoldo;Concetta Quintarelli;Aruna Mahendravada

  • T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model.

    Antonio Di Stasi;Biagio De Angelis;Cliona M. Rooney;Lan Zhang

  • Infusion of donor-derived CD19-redirected virus-specific T cells for B-cell malignancies relapsed after allogeneic stem cell transplant: a phase 1 study

    Conrad Russell Y. Cruz;Kenneth P. Micklethwaite;Barbara Savoldo;Carlos A. Ramos

  • CAR T Cells Administered in Combination with Lymphodepletion and PD-1 Inhibition to Patients with Neuroblastoma.

    Andras Heczey;Chrystal U. Louis;Barbara Savoldo;Olga Dakhova

  • Antitumor Responses in the Absence of Toxicity in Solid Tumors by Targeting B7-H3 via Chimeric Antigen Receptor T Cells

    Hongwei Du;Koichi Hirabayashi;Sarah Ahn;Nancy Porterfield Kren

  • Clinical and immunological responses after CD30-specific chimeric antigen receptor–redirected lymphocytes

    Carlos A. Ramos;Brandon Ballard;Huimin Zhang;Olga Dakhova

  • CD44v6-targeted T cells mediate potent antitumor effects against acute myeloid leukemia and multiple myeloma

    Monica Casucci;Benedetta Nicolis di Robilant;Laura Falcone;Barbara Camisa

  • Anti-CD30 CAR-T Cell Therapy in Relapsed and Refractory Hodgkin Lymphoma.

    Carlos A. Ramos;Carlos A. Ramos;Natalie S. Grover;Anne W. Beaven;Premal D. Lulla;Premal D. Lulla

  • Functionally active virus-specific T-cells that target CMV, adenovirus and EBV can be expanded from naive T-cell populations in cord blood and will target a range of viral epitopes

    Patrick J. Hanley;Conrad Russell Young Cruz;Barbara Savoldo;Ann M. Leen

  • Armed Oncolytic Virus Enhances Immune Functions of Chimeric Antigen Receptor–Modified T Cells in Solid Tumors

    Nobuhiro Nishio;Iulia Diaconu;Hao Liu;Vincenzo Cerullo

  • Quantitative EBV viral loads and immunosuppression alterations can decrease PTLD incidence in pediatric liver transplant recipients.

    Timothy C. Lee;Barbara Savoldo;Cliona M. Rooney;Helen E. Heslop

  • Tumor indoleamine 2,3-dioxygenase (IDO) inhibits CD19-CAR T cells and is downregulated by lymphodepleting drugs

    Soranobu Ninomiya;Neeharika Narala;Leslie Huye;Shigeki Yagyu

  • T lymphocytes redirected against the κ light chain of human immunoglobulin efficiently kill mature B lymphocyte-derived malignant cells

    Juan Vera;Barbara Savoldo;Stephane Vigouroux;Ettore Biagi

Frequent Co-Authors

Gianpietro Dotti
Gianpietro Dotti University of North Carolina at Chapel Hill
Helen E. Heslop
Helen E. Heslop Baylor College of Medicine
Cliona M. Rooney
Cliona M. Rooney Baylor College of Medicine
Malcolm K. Brenner
Malcolm K. Brenner Baylor College of Medicine
Adrian P. Gee
Adrian P. Gee Baylor College of Medicine
Catherine M. Bollard
Catherine M. Bollard George Washington University
Hao Liu
Hao Liu Indiana University
Elizabeth J. Shpall
Elizabeth J. Shpall The University of Texas MD Anderson Cancer Center
Ann M. Leen
Ann M. Leen Baylor College of Medicine
Stephen Gottschalk
Stephen Gottschalk St. Jude Children's Research Hospital

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