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Crystal L. Mackall

Crystal L. Mackall

D-Index & Metrics

Immunology

D-Index
114
Citations
55470
World Ranking
406
National Ranking
249

Medicine

D-Index
114
Citations
55537
World Ranking
4676
National Ranking
2538

Research.com Recognitions

  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Crystal L. Mackall is affiliated with Stanford University in the United States and conducts extensive research predominantly within the field of Medicine. Their work encompasses several focused subfields including Oncology, Immunology, Molecular Biology, Genetics, and Public Health, Environmental and Occupational Health.

The scientist's research topics prominently include CAR-T cell therapy research, Immune Cell Function and Interaction, Virus-based gene therapy research, Viral Infectious Diseases and Gene Expression in Insects, Acute Lymphoblastic Leukemia research, Neuroblastoma Research and Treatments, and Immunotherapy and Immune Responses.

Notable recent publications by Crystal L. Mackall include:

  • "Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling," 2021, Science
  • "Tuning the Antigen Density Requirement for CAR T-cell Activity," 2020, Cancer Discovery
  • "The Emerging Landscape of Immune Cell Therapies," 2020, Cell
  • "CD4/CD8 T-Cell Selection Affects Chimeric Antigen Receptor (CAR) T-Cell Potency and Toxicity: Updated Results From a Phase I Anti-CD22 CAR T-Cell Trial," 2020, Journal of Clinical Oncology
  • "Long-Term Follow-Up of CD19-CAR T-Cell Therapy in Children and Young Adults With B-ALL," 2021, Journal of Clinical Oncology

Frequent coauthors collaborating with Crystal L. Mackall include Liora M. Schultz, Bita Sahaf, Christina Baggott, Elena Sotillo, and Snehit Prabhu.

The scientist has published extensively in several journals with high frequency in the following venues:

  • Blood
  • Transplantation and Cellular Therapy
  • Cancer Research
  • Blood Advances
  • bioRxiv (Cold Spring Harbor Laboratory)

Crystal L. Mackall has received recognition as a Member of the Association of American Physicians.

Best Publications

  • T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial

    Daniel W Lee;James N Kochenderfer;Maryalice Stetler-Stevenson;Yongzhi K Cui

  • Current concepts in the diagnosis and management of cytokine release syndrome

    Daniel W. Lee;Rebecca Gardner;David L. Porter;Chrystal U. Louis

  • Tumor Regression in Patients With Metastatic Synovial Cell Sarcoma and Melanoma Using Genetically Engineered Lymphocytes Reactive With NY-ESO-1

    Paul F. Robbins;Richard A. Morgan;Steven A. Feldman;James C. Yang

  • 4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

    Adrienne H Long;Waleed M Haso;Jack F Shern;Kelsey M Wanhainen

  • CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy.

    Terry J Fry;Nirali N Shah;Rimas J Orentas;Maryalice Stetler-Stevenson

  • Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy

    Elena Sotillo;David M. Barrett;Kathryn L. Black;Asen Bagashev

  • Age, thymopoiesis, and CD4+ t-lymphocyte regeneration after intensive chemotherapy

    Crystal L. Mackall;Thomas A. Fleisher;Margaret R. Brown;Mary P. Andrich

  • GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas

    Unknown

  • Tumor Antigen Escape from CAR T-cell Therapy.

    Robbie G. Majzner;Crystal L. Mackall

  • c-Jun overexpression in CAR T cells induces exhaustion resistance

    Rachel C. Lynn;Evan W. Weber;Elena Sotillo;David Gennert

  • Disruption of CXCR2-mediated MDSC tumor trafficking enhances anti-PD1 efficacy

    Steven L. Highfill;Yongzhi Cui;Amber J. Giles;Jillian P. Smith

  • The Many Faces of IL-7: From Lymphopoiesis to Peripheral T Cell Maintenance

    Terry J. Fry;Crystal L. Mackall

  • Anti-CD22–chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia

    Waleed Haso;Daniel W. Lee;Nirali N. Shah;Maryalice Stetler-Stevenson

  • Harnessing the biology of IL-7 for therapeutic application

    Crystal L. Mackall;Terry J. Fry;Ronald E. Gress

  • CAR T Cells Targeting B7-H3, a Pan-Cancer Antigen, Demonstrate Potent Preclinical Activity Against Pediatric Solid Tumors and Brain Tumors.

    Robbie G. Majzner;Johanna L. Theruvath;Anandani Nellan;Sabine Heitzeneder

  • Interleukin-7: from bench to clinic.

    Terry J. Fry;Crystal L. Mackall

  • Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets

    Claude Sportès;Frances T. Hakim;Sarfraz A. Memon;Hua Zhang

  • Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling.

    Evan W. Weber;Kevin R. Parker;Elena Sotillo;Rachel C. Lynn

  • CAR T cells with dual targeting of CD19 and CD22 in adult patients with recurrent or refractory B cell malignancies: a phase 1 trial

    Jay Y. Spiegel;Shabnum Patel;Lori Muffly;Nasheed M. Hossain

  • Tuning the Antigen Density Requirement for CAR T-cell Activity.

    Robbie G. Majzner;Skyler P. Rietberg;Elena Sotillo;Rui Dong

  • IL-7 administration to humans leads to expansion of CD8+ and CD4+ cells but a relative decrease of CD4+ T-regulatory cells.

    Steven A. Rosenberg;Claude Sportès;Mojgan Ahmadzadeh;Terry J. Fry

  • A potential role for interleukin-7 in T-cell homeostasis

    Terry J. Fry;Elizabeth Connick;Judith Falloon;Michael Marcel Lederman

  • Thymic-independent T cell regeneration occurs via antigen-driven expansion of peripheral T cells resulting in a repertoire that is limited in diversity and prone to skewing.

    Crystal L. Mackall;Catherine V. Bare;Larry A. Granger;Susan O. Sharrow

  • Distinctions Between CD8+ and CD4+ T-Cell Regenerative Pathways Result in Prolonged T-Cell Subset Imbalance After Intensive Chemotherapy

    Crystal L. Mackall;Thomas A. Fleisher;Thomas A. Fleisher;Margaret R. Brown;Margaret R. Brown;Mary P. Andrich;Mary P. Andrich

Frequent Co-Authors

Terry J. Fry
Terry J. Fry University of Colorado Denver
Ronald E. Gress
Ronald E. Gress National Institutes of Health
Rimas J. Orentas
Rimas J. Orentas University of Washington
Lee J. Helman
Lee J. Helman Children's Hospital of Los Angeles
Seth M. Steinberg
Seth M. Steinberg National Institutes of Health
Maryalice Stetler-Stevenson
Maryalice Stetler-Stevenson National Institutes of Health
John M. Maris
John M. Maris Children's Hospital of Philadelphia
David F. Stroncek
David F. Stroncek National Institutes of Health
Thomas A. Fleisher
Thomas A. Fleisher National Institutes of Health
Maria Tsokos
Maria Tsokos Beth Israel Deaconess Medical Center

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