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Immunology

D-Index
65
Citations
24935
World Ranking
2802
National Ranking
1323

Overview

Terry J. Fry is affiliated with the University of Colorado Denver in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a substantial focus on Oncology, Molecular Biology, Immunology, and Genetics as subfields.

The main topics of their work include:

  • CAR-T cell therapy research
  • Viral Infectious Diseases and Gene Expression in Insects
  • Virus-based gene therapy research
  • Immune Cell Function and Interaction
  • Acute Lymphoblastic Leukemia research
  • Immunotherapy and Immune Responses
  • CRISPR and Genetic Engineering

Notable recent papers authored or co-authored by Terry J. Fry include:

  • "CAR T cells with dual targeting of CD19 and CD22 in adult patients with recurrent or refractory B cell malignancies: a phase 1 trial" (2021) published in Nature Medicine
  • "CD4/CD8 T-Cell Selection Affects Chimeric Antigen Receptor (CAR) T-Cell Potency and Toxicity: Updated Results From a Phase I Anti-CD22 CAR T-Cell Trial" (2020) published in Journal of Clinical Oncology
  • "Long-Term Follow-Up of CD19-CAR T-Cell Therapy in Children and Young Adults With B-ALL" (2021) published in Journal of Clinical Oncology
  • "Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immune effector cell-related adverse events" (2020) published in Journal for ImmunoTherapy of Cancer
  • "Characterization of HLH-like manifestations as a CRS variant in patients receiving CD22 CAR T cells" (2021) published in Blood

Frequent co-authors collaborating with Terry J. Fry are:

  • Nirali N. Shah
  • M. Eric Kohler
  • Bonnie Yates
  • Haneen Shalabi
  • Aaron E. Foster

Terry J. Fry has contributed extensively to multiple prominent scientific journals. Their most frequent publication venues include:

  • Blood
  • Cancer Research
  • Journal for ImmunoTherapy of Cancer
  • Neuro-Oncology
  • Journal of Clinical Oncology

The body of work by Terry J. Fry reflects a strong focus on CAR-T cell therapy, emphasizing research on therapy potency, toxicity, and long-term outcomes. Their studies also address the clinical management of immune effector cell-related adverse events and manifestations resembling hemophagocytic lymphohistiocytosis (HLH) in the context of CAR T cell treatments.

Best Publications

  • T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial

    Daniel W Lee;James N Kochenderfer;Maryalice Stetler-Stevenson;Yongzhi K Cui

  • 4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

    Adrienne H Long;Waleed M Haso;Jack F Shern;Kelsey M Wanhainen

  • CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy.

    Terry J Fry;Nirali N Shah;Rimas J Orentas;Maryalice Stetler-Stevenson

  • Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy

    Elena Sotillo;David M. Barrett;Kathryn L. Black;Asen Bagashev

  • Mechanisms of resistance to CAR T cell therapy

    Nirali N. Shah;Terry J. Fry

  • The Many Faces of IL-7: From Lymphopoiesis to Peripheral T Cell Maintenance

    Terry J. Fry;Crystal L. Mackall

  • Harnessing the biology of IL-7 for therapeutic application

    Crystal L. Mackall;Terry J. Fry;Ronald E. Gress

  • Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell

    Marco Ruella;Jun Xu;David M. Barrett;Joseph A. Fraietta

  • Interleukin-7: from bench to clinic.

    Terry J. Fry;Crystal L. Mackall

  • Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets

    Claude Sportès;Frances T. Hakim;Sarfraz A. Memon;Hua Zhang

  • CAR T cells with dual targeting of CD19 and CD22 in adult patients with recurrent or refractory B cell malignancies: a phase 1 trial

    Jay Y. Spiegel;Shabnum Patel;Lori Muffly;Nasheed M. Hossain

  • IL-7 administration to humans leads to expansion of CD8+ and CD4+ cells but a relative decrease of CD4+ T-regulatory cells.

    Steven A. Rosenberg;Claude Sportès;Mojgan Ahmadzadeh;Terry J. Fry

  • A potential role for interleukin-7 in T-cell homeostasis

    Terry J. Fry;Elizabeth Connick;Judith Falloon;Michael Marcel Lederman

  • CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity

    Elad Jacoby;Sang M. Nguyen;Thomas J. Fountaine;Kathryn Welp

  • CD4/CD8 T-Cell Selection Affects Chimeric Antigen Receptor (CAR) T-Cell Potency and Toxicity: Updated Results From a Phase I Anti-CD22 CAR T-Cell Trial

    Nirali N. Shah;Steven L. Highfill;Haneen Shalabi;Bonnie Yates

  • Generation of clinical-grade CD19-specific CAR-modified CD8+ memory stem cells for the treatment of human B-cell malignancies.

    Marianna Sabatino;Jinhui Hu;Michele Sommariva;Michele Sommariva;Sanjivan Gautam

  • Interleukin-7: master regulator of peripheral T-cell homeostasis?

    Terry J. Fry;Crystal L. Mackall

  • IL-7 increases both thymic-dependent and thymic-independent T-cell regeneration after bone marrow transplantation

    Crystal L. Mackall;Terry J. Fry;Cathy Bare;Paul Morgan

  • Tumor Antigen and Receptor Densities Regulate Efficacy of a Chimeric Antigen Receptor Targeting Anaplastic Lymphoma Kinase

    Alec J. Walker;Robbie G. Majzner;Ling Zhang;Kelsey Wanhainen

  • Long-Term Follow-Up of CD19-CAR T-Cell Therapy in Children and Young Adults With B-ALL.

    Nirali N Shah;Daniel W Lee;Bonnie Yates;Constance M Yuan

  • A Role for Thymic Stromal Lymphopoietin in CD4+ T Cell Development

    Amin Al-Shami;Rosanne Spolski;John Kelly;Terry Fry

Frequent Co-Authors

Crystal L. Mackall
Crystal L. Mackall Stanford University
Maryalice Stetler-Stevenson
Maryalice Stetler-Stevenson National Institutes of Health
Ronald E. Gress
Ronald E. Gress National Institutes of Health
David F. Stroncek
David F. Stroncek National Institutes of Health
Seth M. Steinberg
Seth M. Steinberg National Institutes of Health
Rimas J. Orentas
Rimas J. Orentas University of Washington
James N. Kochenderfer
James N. Kochenderfer National Institutes of Health
Peter D. Aplan
Peter D. Aplan National Institutes of Health
David F. Stroncek
David F. Stroncek National Institutes of Health
Stephan A. Grupp
Stephan A. Grupp Children's Hospital of Philadelphia

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