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Molecular Biology

D-Index
65
Citations
11561
World Ranking
1688
National Ranking
852

Overview

Peter D. Aplan is affiliated with the National Institutes of Health in the United States. Their research primarily addresses topics in Medicine and Biochemistry, Genetics, and Molecular Biology. Within these areas, their work has extensive involvement in Molecular Biology and Hematology, with additional contributions to Public Health, Environmental and Occupational Health, Genetics, and Oncology.

The scientist's research covers multiple topics linked to leukemia and cancer biology, including:

  • Acute Myeloid Leukemia Research
  • Acute Lymphoblastic Leukemia Research
  • Chronic Myeloid Leukemia Treatments
  • Chronic Lymphocytic Leukemia Research
  • Hematopoietic Stem Cell Transplantation
  • Lymphoma Diagnosis and Treatment
  • Cancer Genomics and Diagnostics

Peter D. Aplan has contributed publications to several frequent venues. These include:

  • Cancer Research
  • Blood
  • Leukemia
  • Blood Advances
  • Research Square (Research Square)

They have worked collaboratively with multiple co-authors, with frequent collaborators being:

  • Ryan Bertoli
  • Yang Jo Chung
  • Paul S. Meltzer
  • Robert L. Walker
  • Yuelin J. Zhu

Some recent significant papers include:

  • "CENP-A overexpression promotes aneuploidy with karyotypic heterogeneity," 2021, The Journal of Cell Biology
  • "Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion," 2020, Nature Communications
  • "Clinical and molecular consequences of fusion genes in myeloid malignancies," 2020, Stem Cells
  • "Mutant Idh2 Cooperates with a NUP98-HOXD13 Fusion to Induce Early Immature Thymocyte Precursor ALL," 2021, Cancer Research
  • "Moving toward a conceptualization of measurable residual disease in myelodysplastic syndromes," 2023, Blood Advances

Best Publications

  • The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif.

    C G Begley;P D Aplan;S M Denning;B F Haynes

  • Genome Organization Drives Chromosome Fragility

    Andres Canela;Yaakov Maman;Seolkyoung Jung;Nancy Wong

  • NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights

    Sheryl M. Gough;Christopher I. Slape;Peter D. Aplan

  • Disruption of the human SCL locus by "illegitimate" V-(D)-J recombinase activity.

    Peter D. Aplan;Donald P. Lombardi;Ann M. Ginsberg;Jeffrey Cossman

  • Chromosomal translocation in a human leukemic stem-cell line disrupts the T-cell antigen receptor delta-chain diversity region and results in a previously unreported fusion transcript

    C. G. Begley;P. D. Aplan;M. P. Davey;K. Nakahara

  • A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in de novo childhood acute myeloid leukemia.

    Rina J. Jaju;Carrie Fidler;Oskar A. Haas;Amanda J. Strickson

  • SCL and LMO1 alter thymocyte differentiation: inhibition of E2A-HEB function and pre-T alpha chain expression.

    Sabine Herblot;Ann-Muriel Steff;Patrice Hugo;Peter D. Aplan

  • The SCL gene product : a positive regulator of erythroid differentiation

    P.D. Aplan;K. Nakahara;S.H. Orkin;I.R. Kirsch

  • NUP98-HOXD13 transgenic mice develop a highly penetrant, severe myelodysplastic syndrome that progresses to acute leukemia

    Ying-Wei Lin;Christopher Slape;Zhenhua Zhang;Peter D. Aplan

  • Causes of oncogenic chromosomal translocation.

    Peter D. Aplan

  • NUP98-HOXD13 gene fusion in therapy-related acute myelogenous leukemia

    Samina Z. Raza-Egilmez;Sheila N. Jani-Sait;Mauro Grossi;Michael J. Higgins

  • Site-specific DNA cleavage within the MLL breakpoint cluster region induced by topoisomerase II inhibitors.

    Peter D. Aplan;David S. Chervinsky;Martin Stanulla;William C. Burhans

  • DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier

    Margarida A. Santos;Robert B. Faryabi;Aysegul V. Ergen;Amanda M. Day

  • DNA cleavage within the MLL breakpoint cluster region is a specific event which occurs as part of higher-order chromatin fragmentation during the initial stages of apoptosis.

    Martin Stanulla;Junjie Wang;David S. Chervinsky;Srinivas Thandla

  • Cytogenetics and Molecular Genetics of Acute Lymphoblastic Leukemia

    Krzysztof Mrózek;David P. Harper;Peter D. Aplan

  • Loss of Smad3 in acute T-cell lymphoblastic leukemia.

    Lawrence A. Wolfraim;Tania M. Fernandez;Mizuko Mamura;Walter L. Fuller

  • Dual Roles of Poly(dA:dT) Tracts in Replication Initiation and Fork Collapse.

    Anthony Tubbs;Sriram Sridharan;Niek van Wietmarschen;Yaakov Maman

  • A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma

    Ying Wei Lin;Zanna M. Beharry;Elizabeth G. Hill;Jin H. Song

  • An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T‐cell malignancies in transgenic mice

    Peter D. Aplan;Peter D. Aplan;Craig A. Jones;David S. Chervinsky;XianFeng Zhao

  • Induction of acute myeloid leukemia in mice by the human leukemia-specific fusion gene NUP98-HOXD13 in concert with Meis1.

    Nicolas Pineault;Nicolas Pineault;Christian Buske;Christian Buske;Michaela Feuring-Buske;Michaela Feuring-Buske;Carolina Abramovich;Carolina Abramovich

Frequent Co-Authors

Paul S. Meltzer
Paul S. Meltzer National Institutes of Health
Terry J. Fry
Terry J. Fry University of Colorado Denver
Donald Small
Donald Small Johns Hopkins University
Ilan R. Kirsch
Ilan R. Kirsch Adaptive Biotechnologies (United States)
Fotini Gounari
Fotini Gounari University of Chicago
Crystal L. Mackall
Crystal L. Mackall Stanford University
Michelle A. Kelliher
Michelle A. Kelliher University of Massachusetts Chan Medical School
Irving Kirsch
Irving Kirsch Harvard University
Adolfo A. Ferrando
Adolfo A. Ferrando Columbia University
Andrew S. Kraft
Andrew S. Kraft University of Arizona

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Related Online Degrees & Career Pathways

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