D-Index & Metrics Best Publications
Research.com 2022 Best Scientist Award Badge
Genetics and Molecular Biology
USA
2022

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Genetics and Molecular Biology D-index 218 Citations 151,103 666 World Ranking 4 National Ranking 3
Best Scientists D-index 238 Citations 182,073 790 World Ranking 49 National Ranking 34

Research.com Recognitions

Awards & Achievements

2022 - Research.com Best Scientist Award

2022 - Research.com Genetics and Molecular Biology in United States Leader Award

2020 - King Faisal Prize

2016 - Karl Landsteiner Memorial Award, American Association of Blood Banks (AABB)

2014 - William Allan Award, the American Society of Human Genetics

2013 - Jessie Stevenson Kovalenko Medal, US National Academy of Sciences For his pioneering achievements in defining the molecular basis of blood disorders and the mechanisms governing the development of blood stem cells and individual blood lineages. His work has significantly advanced our understanding of human hematologic diseases and revealed new strategies to prevent and manage these disorders.

2010 - Fellow of the American Association for the Advancement of Science (AAAS)

1993 - Fellow of the American Academy of Arts and Sciences

1993 - Warren Alpert Foundation Prize For developing a complete description of thalassemia at the molecular level.

1992 - Member of the National Academy of Medicine (NAM)

1991 - Member of the National Academy of Sciences

1987 - E. Mead Johnson Award, Society for Pediatric Research

Member of the Association of American Physicians

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • DNA
  • Genetics

Molecular biology, Cell biology, Genetics, Haematopoiesis and Cellular differentiation are his primary areas of study. His studies in Molecular biology integrate themes in fields like Complementary DNA, Transcription factor, Gene expression, Gene and Erythroid-Specific DNA-Binding Factors. His Transcription factor study incorporates themes from Promoter and Regulation of gene expression.

He works in the field of Cell biology, namely Stem cell. His study in Haematopoiesis is interdisciplinary in nature, drawing from both Progenitor cell and Cancer research. Stuart H. Orkin interconnects SOX2 and Homeobox protein NANOG in the investigation of issues within Cellular differentiation.

His most cited work include:

  • Epigenetic memory in induced pluripotent stem cells (1761 citations)
  • Hematopoiesis: an evolving paradigm for stem cell biology. (1723 citations)
  • An early haematopoietic defect in mice lacking the transcription factor GATA-2. (1205 citations)

What are the main themes of his work throughout his whole career to date?

Stuart H. Orkin focuses on Molecular biology, Cell biology, Genetics, Gene and Transcription factor. His Molecular biology research is multidisciplinary, incorporating perspectives in GATA1, Gene expression, Complementary DNA, Globin and Erythroid-Specific DNA-Binding Factors. Stuart H. Orkin works mostly in the field of Cell biology, limiting it down to topics relating to Embryonic stem cell and, in certain cases, Reprogramming, as a part of the same area of interest.

His Gene research is mostly focused on the topic Transcription. His Haematopoiesis research integrates issues from Progenitor cell, Cancer research, Bone marrow and Erythropoiesis. His biological study spans a wide range of topics, including Enhancer and Epigenetics.

He most often published in these fields:

  • Molecular biology (45.70%)
  • Cell biology (45.80%)
  • Genetics (37.51%)

What were the highlights of his more recent work (between 2012-2021)?

  • Cell biology (45.80%)
  • Genetics (37.51%)
  • Regulation of gene expression (22.24%)

In recent papers he was focusing on the following fields of study:

His main research concerns Cell biology, Genetics, Regulation of gene expression, Chromatin and Cancer research. Stuart H. Orkin has researched Cell biology in several fields, including Embryonic stem cell, Transcription factor and Gene expression. His Regulation of gene expression research incorporates elements of Translation and MYB.

His Chromatin research also works with subjects such as

  • Enhancer that intertwine with fields like Computational biology, GATA1 and Locus,
  • Histone which intersects with area such as Super-enhancer and Cohesin. Stuart H. Orkin has included themes like Cell, Cellular differentiation and Immunology in his Stem cell study. His research integrates issues of Molecular biology, Erythropoiesis, Bone marrow and Transplantation in his study of Haematopoiesis.

Between 2012 and 2021, his most popular works were:

  • A comparative encyclopedia of DNA elements in the mouse genome (1022 citations)
  • Mapping the Mouse Cell Atlas by Microwell-Seq (614 citations)
  • BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis (546 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • DNA
  • Genetics

Stuart H. Orkin mainly investigates Genetics, Regulation of gene expression, Chromatin, Cell biology and Stem cell. His study ties his expertise on Transcription factor together with the subject of Regulation of gene expression. His Chromatin research incorporates themes from Promoter, Chromatin immunoprecipitation, Gene expression and Epigenetics.

His research in Cell biology tackles topics such as Cellular differentiation which are related to areas like Molecular biology, Cell and Cell growth. His work carried out in the field of Molecular biology brings together such families of science as Gene knockdown and Single-cell analysis. His study in Stem cell focuses on Haematopoiesis and Progenitor cell.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Hematopoiesis: an evolving paradigm for stem cell biology.

Stuart H. Orkin;Leonard I. Zon;Leonard I. Zon.
Cell (2008)

2472 Citations

Epigenetic memory in induced pluripotent stem cells

K. Kim;A. Doi;B. Wen;K. Ng.
Nature (2010)

2273 Citations

An early haematopoietic defect in mice lacking the transcription factor GATA-2.

Fong-Ying Tsai;Fong-Ying Tsai;Gordon Keller;Frank C. Kuo;Mitchell Weiss.
Nature (1994)

1597 Citations

Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping

Manfred Gessler;Annemarie Poustka;Webster Cavenee;Rachael L. Neve.
Nature (1990)

1536 Citations

Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1

Larysa Pevny;M. Celeste Simon;Elizabeth Robertson;William H. Klein.
Nature (1991)

1484 Citations

An extended transcriptional network for pluripotency of embryonic stem cells

Jonghwan Kim;Jianlin Chu;Xiaohua Shen;Jianlong Wang.
Cell (2008)

1444 Citations

A protein interaction network for pluripotency of embryonic stem cells

Jianlong Wang;Sridhar Rao;Jianlin Chu;Xiaohua Shen.
Nature (2006)

1225 Citations

A comparative encyclopedia of DNA elements in the mouse genome

Feng Yue;Feng Yue;Yong Cheng;Alessandra Breschi;Jeff Vierstra.
Nature (2014)

1220 Citations

Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis

Trista E. North;Wolfram Goessling;Wolfram Goessling;Carl R. Walkley;Claudia Lengerke.
Nature (2007)

1107 Citations

Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL.

Ramesh A. Shivdasani;Ramesh A. Shivdasani;Erica L. Mayer;Erica L. Mayer;Stuart H. Orkin;Stuart H. Orkin.
Nature (1995)

1083 Citations

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