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Best Scientists

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219
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154333
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144
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Molecular Biology

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220
Citations
155843
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11
National Ranking
7

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220
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Research.com Recognitions

  • 2026 - Research.com Medicine in United States Leader Award
  • 2026 - Research.com Molecular Biology in United States Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Medicine in United States Leader Award
  • 2025 - Research.com Molecular Biology in United States Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in United States Leader Award
  • 2023 - Research.com Molecular Biology in United States Leader Award
  • 2022 - Research.com Genetics and Molecular Biology in United States Leader Award
  • 2020 - King Faisal Prize
  • 2016 - Karl Landsteiner Memorial Award, American Association of Blood Banks (AABB)
  • 2014 - William Allan Award, the American Society of Human Genetics
  • 2013 - Jessie Stevenson Kovalenko Medal, US National Academy of Sciences For his pioneering achievements in defining the molecular basis of blood disorders and the mechanisms governing the development of blood stem cells and individual blood lineages. His work has significantly advanced our understanding of human hematologic diseases and revealed new strategies to prevent and manage these disorders.
  • 2010 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1993 - Warren Alpert Foundation Prize For developing a complete description of thalassemia at the molecular level.
  • 1993 - Fellow of the American Academy of Arts and Sciences
  • 1992 - Member of the National Academy of Medicine (NAM)
  • 1991 - Member of the National Academy of Sciences
  • 1987 - E. Mead Johnson Award, Society for Pediatric Research
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Stuart H. Orkin is affiliated with Harvard University in the United States and has contributed to research primarily within the fields of Biochemistry, Genetics, and Molecular Biology.

Their recent publications span several journals and cover a range of topics in molecular and cellular biology. Notable recent papers include:

  • "An Engineered CRISPR-Cas9 Mouse Line for Simultaneous Readout of Lineage Histories and Gene Expression Profiles in Single Cells" (2020, Cell)
  • "An Engineered CRISPR-Cas9 Mouse Line for Simultaneous Readout of Lineage Histories and Gene Expression Profiles in Single Cells" (2020, Cell)
  • "Transcription factor-mediated intestinal metaplasia and the role of a shadow enhancer" (2021, Genes & Development)
  • "Blood Flow Directs Yap/Taz-Mediated Transcriptional Regulation of Self-Renewal Programs to Control Developmental HSPC Expansion By Mechanical Stimulation of Piezo1" (2023, Blood)
  • "Defining the structure, signals, and cellular elements of the gastric mesenchymal niche" (2023, bioRxiv, Cold Spring Harbor Laboratory)

Frequent coauthors contributing to their work include:

  • Yuko Fujiwara
  • Wade W. Sugden
  • Zachary LeBlanc
  • Maria Gonzalez di Tillio
  • Mohamad Najia

Their publications are found often in these venues:

  • Cell
  • Blood
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Experimental Hematology
  • Genes & Development

Orkin's research covers key subfields such as Molecular Biology, Cell Biology, Oncology, Genetics, and Cancer Research. Major topics addressed in their work include:

  • CRISPR and Genetic Engineering
  • Epigenetics and DNA Methylation
  • Digestive system and related health
  • Hippo pathway signaling and YAP/TAZ
  • Cancer Cells and Metastasis
  • Single-cell and spatial transcriptomics
  • Pluripotent Stem Cells Research

The scientist has received multiple awards including the King Faisal Prize in 2020, the Karl Landsteiner Memorial Award from the American Association of Blood Banks in 2016, and the William Allan Award from the American Society of Human Genetics in 2014.

Other distinctions include the Jessie Stevenson Kovalenko Medal from the US National Academy of Sciences in 2013, recognizing work on the molecular basis of blood disorders and stem cell biology, and the Warren Alpert Foundation Prize in 1993 for describing thalassemia at the molecular level.

They have been named a Fellow of the American Association for the Advancement of Science and the American Academy of Arts and Sciences and hold memberships in the National Academy of Medicine, National Academy of Sciences, and Association of American Physicians.

Best Publications

  • Hematopoiesis: an evolving paradigm for stem cell biology.

    Stuart H. Orkin;Leonard I. Zon;Leonard I. Zon

  • Epigenetic memory in induced pluripotent stem cells

    K. Kim;A. Doi;B. Wen;K. Ng

  • A comparative encyclopedia of DNA elements in the mouse genome

    Feng Yue;Feng Yue;Yong Cheng;Alessandra Breschi;Jeff Vierstra

  • An early haematopoietic defect in mice lacking the transcription factor GATA-2.

    Fong-Ying Tsai;Fong-Ying Tsai;Gordon Keller;Frank C. Kuo;Mitchell Weiss

  • Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping

    Manfred Gessler;Annemarie Poustka;Webster Cavenee;Rachael L. Neve

  • Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1

    Larysa Pevny;M. Celeste Simon;Elizabeth Robertson;William H. Klein

  • An extended transcriptional network for pluripotency of embryonic stem cells

    Jonghwan Kim;Jianlin Chu;Xiaohua Shen;Jianlong Wang

  • Mapping the Mouse Cell Atlas by Microwell-Seq

    Xiaoping Han;Renying Wang;Yincong Zhou;Lijiang Fei

  • A protein interaction network for pluripotency of embryonic stem cells

    Jianlong Wang;Sridhar Rao;Jianlin Chu;Xiaohua Shen

  • Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis

    Trista E. North;Wolfram Goessling;Wolfram Goessling;Carl R. Walkley;Claudia Lengerke

  • Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL.

    Ramesh A. Shivdasani;Erica L. Mayer;Erica L. Mayer;Stuart H. Orkin;Stuart H. Orkin

  • Toward Improving Caenorhabditis elegans Phenome Mapping With an ORFeome-Based RNAi Library

    Jaen François Rual;Julian Ceron;John Koreth;Tong Hao

  • Linkage of β-thalassaemia mutations and β-globin gene polymorphisms with DNA polymorphisms in human β-globin gene cluster

    Stuart H. Orkin;Haig H. Kazazian;Stylianos E. Antonarakis;Sabra C. Goff

  • A critical role for eosinophils in allergic airways remodeling

    Alison A. Humbles;Clare M. Lloyd;Sarah J. McMillan;Daniel S. Friend

  • Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells

    Shih-Feng Tsai;David I. K. Martin;David I. K. Martin;Leonard I. Zon;Leonard I. Zon;Alan D. D'Andrea;Alan D. D'Andrea

  • GATA-binding transcription factors in hematopoietic cells

    SH Orkin

  • EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency.

    Xiaohua Shen;Yingchun Liu;Yu Jung Hsu;Yuko Fujiwara

  • Cloning the gene for an inherited human disorder—chronic granulomatous disease—on the basis of its chromosomal location

    B. Royerpokora;L. M. Kunkel;A. P. Monaco;S. C. Goff

  • Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production

    Jonathan D. Pollock;David A. Williams;David A. Williams;Mary A.C. Gifford;Ling Lin Li

  • Human Fetal Hemoglobin Expression Is Regulated by the Developmental Stage-Specific Repressor BCL11A

    Vijay G. Sankaran;Tobias F. Menne;Jian Xu;Thomas E. Akie

Frequent Co-Authors

Yuko Fujiwara
Yuko Fujiwara Harvard University
Daniel E. Bauer
Daniel E. Bauer Harvard University
Guo-Cheng Yuan
Guo-Cheng Yuan Icahn School of Medicine at Mount Sinai
Leonard I. Zon
Leonard I. Zon Harvard University
Vijay G. Sankaran
Vijay G. Sankaran Harvard University
David G. Nathan
David G. Nathan Harvard University
Alan B. Cantor
Alan B. Cantor Harvard University
David A. Williams
David A. Williams Boston Children's Hospital
George Q. Daley
George Q. Daley Boston Children's Hospital
Hanna K.A. Mikkola
Hanna K.A. Mikkola University of California, Los Angeles

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