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Biology and Biochemistry

D-Index
65
Citations
25086
World Ranking
8954
National Ranking
3976

Overview

Daniel E. Bauer is a researcher affiliated with Harvard University in the United States. Their work spans multiple fields primarily within Biochemistry, Genetics and Molecular Biology, and Medicine. The main subfields of their studies include Molecular Biology, Genetics, Epidemiology, Hematology, and Physiology.

Their research topics prominently focus on CRISPR and Genetic Engineering, Hemoglobinopathies and Related Disorders, Virus-based gene therapy research, Cytomegalovirus and herpesvirus research, RNA modifications and cancer, RNA regulation and disease, and CAR-T cell therapy research.

Recent publications by Daniel E. Bauer include the following papers:

  • "Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity," 2020, Nature Biotechnology
  • "Therapeutic base editing of human hematopoietic stem cells," 2020, Nature Medicine
  • "Improving prime editing with an endogenous small RNA-binding protein," 2024, Nature
  • "Assessing and advancing the safety of CRISPR-Cas tools: from DNA to RNA editing," 2023, Nature Communications
  • "Human genetic diversity alters off-target outcomes of therapeutic gene editing," 2022, Nature Genetics

Frequent co-authors collaborating with Bauer include Jing Zeng, Luca Pinello, Scot A. Wolfe, Stacy A. Maitland, and Christian Brendel.

Their work is published in a variety of scientific venues where they have multiple contributions, including Blood, bioRxiv (Cold Spring Harbor Laboratory), Nature Genetics, Cell Stem Cell, and Nature Biotechnology.

Best Publications

  • Growth factor regulation of autophagy and cell survival in the absence of apoptosis

    Julian J. Lum;Daniel E. Bauer;Mei Kong;Marian H. Harris

  • Dramatic rise in plasma viremia after CD8+ T cell depletion in simian immunodeficiency virus-infected macaques

    Xia Jin;Daniel E. Bauer;Sarah E. Tuttleton;Sharon Lewin

  • Akt stimulates aerobic glycolysis in cancer cells

    Rebecca L. Elstrom;Daniel E. Bauer;Monica Buzzai;Robyn Karnauskas

  • ATP citrate lyase inhibition can suppress tumor cell growth

    Georgia Hatzivassiliou;Fangping Zhao;Daniel E. Bauer;Charalambos Andreadis

  • CRISPResso2 provides accurate and rapid genome editing sequence analysis.

    Clement K;Rees H;Canver Mc;Canver Mc;Gehrke Jm

  • BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis

    Matthew C. Canver;Elenoe C. Smith;Falak Sher;Luca Pinello

  • Alkylating DNA damage stimulates a regulated form of necrotic cell death

    Wei-Xing Zong;Dara Ditsworth;Daniel E. Bauer;Zhao-Qi Wang

  • Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity

    Michelle F. Richter;Kevin T. Zhao;Kevin T. Zhao;Kevin T. Zhao;Elliot Eton;Elliot Eton;Elliot Eton;Audrone Lapinaite

  • An Erythroid Enhancer of BCL11A Subject to Genetic Variation Determines Fetal Hemoglobin Level

    Daniel E. Bauer;Sophia C. Kamran;Sophia C. Kamran;Samuel Lessard;Jian Xu;Jian Xu

  • ATP citrate lyase is an important component of cell growth and transformation

    Daniel E Bauer;Georgia Hatzivassiliou;Fangping Zhao;Charalambos Andreadis

  • The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid β -oxidation

    Monica Buzzai;Daniel E Bauer;Russell G Jones;Ralph J DeBerardinis;Ralph J DeBerardinis

  • Analyzing CRISPR genome-editing experiments with CRISPResso

    Pinello L;Canver Mc;Hoban;Orkin Sh

  • Highly efficient therapeutic gene editing of human hematopoietic stem cells.

    Yuxuan Wu;Jing Zeng;Jing Zeng;Benjamin P. Roscoe;Pengpeng Liu

  • Characterization of Genomic Deletion Efficiency Mediated by Clustered Regularly Interspaced Palindromic Repeats (CRISPR)/Cas9 Nuclease System in Mammalian Cells

    Matthew C. Canver;Daniel E. Bauer;Abhishek Dass;Yvette Y. Yien

  • An APOBEC3A-Cas9 base editor with minimized bystander and off-target activities

    Jason M Gehrke;Oliver Cervantes;M Kendell Clement;Yuxuan Wu

  • Direct Promoter Repression by BCL11A Controls the Fetal to Adult Hemoglobin Switch

    Nan Liu;Victoria V. Hargreaves;Qian Zhu;Jesse V. Kurland

  • Clinicopathologic Features and Long-term Outcomes of NUT Midline Carcinoma

    Daniel E. Bauer;Chelsey M. Mitchell;Kelly M. Strait;Christopher S. Lathan

  • Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin

    Takeshi Masuda;Xin Wang;Manami Maeda;Matthew C. Canver

  • Reawakening fetal hemoglobin: prospects for new therapies for the β-globin disorders

    Daniel E. Bauer;Sophia C. Kamran;Sophia C. Kamran;Stuart H. Orkin

  • Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A

    Jian Xu;Daniel E. Bauer;Marc A. Kerenyi;Thuy D. Vo

Frequent Co-Authors

Stuart H. Orkin
Stuart H. Orkin Harvard University
Barry H. Paw
Barry H. Paw Brigham and Women's Hospital
Guo-Cheng Yuan
Guo-Cheng Yuan Icahn School of Medicine at Mount Sinai
Scot A. Wolfe
Scot A. Wolfe University of Massachusetts Chan Medical School
Guillaume Lettre
Guillaume Lettre Montreal Heart Institute
Alan B. Cantor
Alan B. Cantor Harvard University
Yuko Fujiwara
Yuko Fujiwara Harvard University
Craig B. Thompson
Craig B. Thompson Memorial Sloan Kettering Cancer Center
David R. Liu
David R. Liu Broad Institute

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