World's Best Scientists 2026 revealed!

D-Index & Metrics

Genetics

D-Index
66
Citations
16590
World Ranking
2611
National Ranking
1156

Overview

Scot A. Wolfe is affiliated with the University of Massachusetts Chan Medical School in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with significant contributions to subfields such as Molecular Biology, Genetics, Epidemiology, Public Health, Environmental and Occupational Health, and Hematology.

The topics of their work include:

  • CRISPR and Genetic Engineering
  • Virus-based gene therapy research
  • Cytomegalovirus and herpesvirus research
  • RNA regulation and disease
  • Advanced biosensing and bioanalysis techniques
  • Mosquito-borne diseases and control
  • RNA Interference and Gene Delivery

They have a substantial publication record with recent papers including:

  • Therapeutic base editing of human hematopoietic stem cells, 2020, Nature Medicine
  • Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice, 2021, Nature Communications
  • The NIH Somatic Cell Genome Editing program, 2021, Nature
  • Self-inactivating, all-in-one AAV vectors for precision Cas9 genome editing via homology-directed repair in vivo, 2021, Nature Communications
  • Human genetic diversity alters off-target outcomes of therapeutic gene editing, 2022, Nature Genetics

Frequent coauthors in their work include:

  • Pengpeng Liu
  • Daniel E. Bauer
  • Stacy A. Maitland
  • Kevin Luk
  • Jing Zeng

Their research has been published extensively in several venues, notably:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Blood
  • Nature Communications
  • Cell stem cell
  • Nucleic Acids Research

Best Publications

  • DNA recognition by Cys2His2 zinc finger proteins.

    Scot A. Wolfe;Lena Nekludova;Carl O. Pabo

  • A Novel miRNA Processing Pathway Independent of Dicer Requires Argonaute2 Catalytic Activity

    Daniel Cifuentes;Huiling Xue;David W. Taylor;Heather Patnode

  • Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases

    Xiangdong Meng;Marcus Blaine Noyes;Lihua Julie Zhu;Nathan D. Lawson

  • Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo

    Hao Yin;Chun-Qing Song;Joseph R. Dorkin;Lihua Julie Zhu

  • Reverse genetic screening reveals poor correlation between morpholino-induced and mutant phenotypes in zebrafish

    Fatma O. Kok;Masahiro Shin;Chih Wen Ni;Ankit Gupta

  • Analysis of homeodomain specificities allows the family-wide prediction of preferred recognition sites

    Marcus Blaine Noyes;Ryan G. Christensen;Atsuya Wakabayashi;Gary D. Stormo

  • Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing

    Hao Yin;Chun-Qing Song;Sneha Suresh;Qiongqiong Wu

  • Multicolor CRISPR labeling of chromosomal loci in human cells

    Hanhui Ma;Ardalan Naseri;Pablo Reyes-Gutierrez;Scot A. Wolfe

  • Highly efficient therapeutic gene editing of human hematopoietic stem cells.

    Yuxuan Wu;Jing Zeng;Jing Zeng;Benjamin P. Roscoe;Pengpeng Liu

  • Cas9 effector-mediated regulation of transcription and differentiation in human pluripotent stem cells

    Nicola A. Kearns;Ryan M. J. Genga;Metewo Selase Enuameh;Manuel Garber

  • Analysis of zinc fingers optimized via phage display: evaluating the utility of a recognition code.

    Scot A. Wolfe;Harvey A. Greisman;Elizabeth I. Ramm;Carl O. Pabo

  • A bacterial one-hybrid system for determining the DNA-binding specificity of transcription factors

    Xiangdong Meng;Michael H Brodsky;Scot A Wolfe

  • FlyFactorSurvey: a database of Drosophila transcription factor binding specificities determined using the bacterial one-hybrid system

    Lihua Julie Zhu;Ryan G. Christensen;Majid Kazemian;Christopher J. Hull

  • Therapeutic base editing of human hematopoietic stem cells.

    Jing Zeng;Yuxuan Wu;Yuxuan Wu;Chunyan Ren;Jasmine Bonanno

  • Partial DNA-guided Cas9 enables genome editing with reduced off-target activity.

    Hao Yin;Chun-Qing Song;Sneha Suresh;Suet-Yan Kwan

  • Forward and reverse genetic approaches for the analysis of vertebrate development in the zebrafish.

    Nathan D. Lawson;Scot A. Wolfe

  • Arterial-venous network formation during brain vascularization involves hemodynamic regulation of chemokine signaling

    Jeroen Bussmann;Scot A. Wolfe;Arndt F. Siekmann

  • Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice.

    Pengpeng Liu;Shun-Qing Liang;Chunwei Zheng;Esther Mintzer

  • A systematic characterization of factors that regulate Drosophila segmentation via a bacterial one-hybrid system

    Marcus Blaine Noyes;Xiangdong Meng;Atsuya Wakabayashi;Saurabh Sinha

  • Beyond the "recognition code": structures of two Cys2His2 zinc finger/TATA box complexes.

    Scot A. Wolfe;Robert A. Grant;Monicia Elrod-Erickson;Carl O. Pabo

Frequent Co-Authors

Lihua Julie Zhu
Lihua Julie Zhu University of Massachusetts Chan Medical School
Daniel E. Bauer
Daniel E. Bauer Harvard University
Erik J. Sontheimer
Erik J. Sontheimer University of Massachusetts Chan Medical School
Nathan D. Lawson
Nathan D. Lawson University of Massachusetts Chan Medical School
Gary D. Stormo
Gary D. Stormo Washington University in St. Louis
Saurabh Sinha
Saurabh Sinha University of Illinois at Urbana-Champaign
Shengdar Q. Tsai
Shengdar Q. Tsai St. Jude Children's Research Hospital
Wen Xue
Wen Xue University of Massachusetts Chan Medical School
Job Dekker
Job Dekker University of Massachusetts Chan Medical School

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Studying Genetics in the USA can open doors to a wide range of careers in healthcare and research. Many students interested in genetics also explore fields such as medical administration, nursing, and coding, as these areas are closely linked within the healthcare system.

For those seeking flexible and affordable options, consider exploring the medical billing and coding field. This area offers online programs that can lead to in-demand healthcare support roles. If you are interested in patient care, some of the easy nursing colleges to get into may provide a streamlined pathway to becoming a registered nurse.

In addition, those aiming for leadership positions in healthcare should consider the online healthcare administration programs that can be completed quickly through accelerated tracks. Budget-conscious students will also benefit from exploring some of the online healthcare administration programs known for their affordability and flexibility. Each of these related career pathways can complement a foundation in Genetics, broadening your future options in the health sector.

Best Scientists Citing Scot A. Wolfe

Trending Scientists

Recently Published Articles