Scot A. Wolfe spends much of his time researching Genetics, Computational biology, Cell biology, Gene and Zebrafish. His works in Regulation of gene expression, Binding site, Genome, Drosophila melanogaster and Induced pluripotent stem cell are all subjects of inquiry into Genetics. His research in Computational biology intersects with topics in Subgenomic mRNA, Zinc finger, Cas9 and DNA sequencing.
His biological study deals with issues like Embryonic stem cell, which deal with fields such as Zinc finger nuclease, Cell fate determination, Gene regulatory network and Model organism. His research investigates the connection with Gene and areas like Function which intersect with concerns in Animal development, Vertebrate, Zoology and Gene expression. The various areas that Scot A. Wolfe examines in his Zebrafish study include Chemokine, Chemokine receptor and Signal transduction, Notch signaling pathway.
Scot A. Wolfe focuses on Computational biology, Genetics, Cell biology, Genome editing and Genome. His Computational biology research integrates issues from Proteome, Guide RNA and DNA, DNA sequencing. His study in Genetics concentrates on Zinc finger, Gene, Binding site, Zebrafish and Gene targeting.
His Cell biology study integrates concerns from other disciplines, such as Chromatin, Gene silencing, Enhancer and CHD4. The Genome editing study which covers Cas9 that intersects with Nuclease, RNA and Subgenomic mRNA. His Genome study combines topics from a wide range of disciplines, such as Drosophila Protein and Somatic cell.
Scot A. Wolfe mainly focuses on Cell biology, Genome editing, Computational biology, Cas9 and Genome. Scot A. Wolfe has researched Cell biology in several fields, including Chromatin, Transcription factor, CHD4 and Globin. His Computational biology study combines topics in areas such as Proteome, Peak calling, DNA and Guide RNA.
His Cas9 research includes elements of RNA, Subgenomic mRNA, Nuclear localization sequence and Nuclease. His Nuclease research entails a greater understanding of Genetics. His biological study spans a wide range of topics, including Polymerase, Transcription and Somatic cell.
Scot A. Wolfe mostly deals with Cell biology, Genome editing, Computational biology, Cas9 and Nuclease. His studies deal with areas such as Enhancer and Regulation of gene expression as well as Cell biology. His studies in Computational biology integrate themes in fields like Biotinylation, Genome, Bioconductor and CRISPR.
In the subject of general Genome, his work in Genomics is often linked to Identification, thereby combining diverse domains of study. His study on CRISPR is covered under Genetics. Synthetic biology and In vivo is closely connected to RNA in his research, which is encompassed under the umbrella topic of Cas9.
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DNA recognition by Cys2His2 zinc finger proteins.
Scot A. Wolfe;Lena Nekludova;Carl O. Pabo.
Annual Review of Biophysics and Biomolecular Structure (2000)
A Novel miRNA Processing Pathway Independent of Dicer Requires Argonaute2 Catalytic Activity
Daniel Cifuentes;Huiling Xue;David W. Taylor;Heather Patnode.
Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases
Xiangdong Meng;Marcus Blaine Noyes;Lihua Julie Zhu;Nathan D. Lawson.
Nature Biotechnology (2008)
Reverse genetic screening reveals poor correlation between morpholino-induced and mutant phenotypes in zebrafish
Fatma O. Kok;Masahiro Shin;Chih Wen Ni;Ankit Gupta.
Developmental Cell (2015)
Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo
Hao Yin;Chun-Qing Song;Joseph R. Dorkin;Lihua Julie Zhu.
Nature Biotechnology (2016)
Analysis of homeodomain specificities allows the family-wide prediction of preferred recognition sites
Marcus Blaine Noyes;Ryan G. Christensen;Atsuya Wakabayashi;Gary D. Stormo.
Multicolor CRISPR labeling of chromosomal loci in human cells
Hanhui Ma;Ardalan Naseri;Pablo Reyes-Gutierrez;Scot A. Wolfe.
Proceedings of the National Academy of Sciences of the United States of America (2015)
Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing
Hao Yin;Chun-Qing Song;Sneha Suresh;Qiongqiong Wu.
Nature Biotechnology (2017)
Analysis of zinc fingers optimized via phage display: evaluating the utility of a recognition code.
Scot A. Wolfe;Harvey A. Greisman;Elizabeth I. Ramm;Carl O. Pabo.
Journal of Molecular Biology (1999)
Cas9 effector-mediated regulation of transcription and differentiation in human pluripotent stem cells
Nicola A. Kearns;Ryan M. J. Genga;Metewo Selase Enuameh;Manuel Garber.
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