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Genetics

D-Index
68
Citations
17859
World Ranking
2425
National Ranking
1092

Overview

David J. Segal is affiliated with the University of California, Davis in the United States. Their research primarily spans the field of Biochemistry, Genetics and Molecular Biology, with a focus on several subfields including Molecular Biology, Genetics, Pediatrics, Perinatology and Child Health, Cancer Research, and Oncology. The breadth of their work covers key topics such as Genetic Syndromes and Imprinting, CRISPR and Genetic Engineering, Epigenetics and DNA Methylation, Virus-based gene therapy research, Genetics and Neurodevelopmental Disorders, Genomics and Chromatin Dynamics, and Advanced biosensing and bioanalysis techniques.

Frequent venues for publication in Segal's career include Frontiers in Genome Editing, bioRxiv (Cold Spring Harbor Laboratory), Nucleic Acids Research, Human Molecular Genetics, and Cancer Research. These platforms have featured multiple contributions that reflect their ongoing engagement with various aspects of genome editing and molecular genetics.

Segal has co-authored extensively with several researchers in their field. Notable frequent collaborators are Henriette O'Geen, Jill L. Silverman, Scott V. Dindot, Ulrika Beitnere, and Nycole A. Copping, with co-author counts ranging from six to fifteen joint publications.

Selected recent papers from Segal's body of work include:

  • "The NIH Somatic Cell Genome Editing program" (2021, Nature)
  • "An ASO therapy for Angelman syndrome that targets an evolutionarily conserved region at the start of the UBE3A-AS transcript" (2023, Science Translational Medicine)
  • "Translational outcomes in a full gene deletion of ubiquitin protein ligase E3A rat model of Angelman syndrome" (2020, Translational Psychiatry)
  • "Determinants of heritable gene silencing for KRAB-dCas9 + DNMT3 and Ezh2-dCas9 + DNMT3 hit-and-run epigenome editing" (2022, Nucleic Acids Research)
  • "Functional rescue in an Angelman syndrome model following treatment with lentivector transduced hematopoietic stem cells" (2021, Human Molecular Genetics)

Best Publications

  • TLR3 deficiency in patients with herpes simplex encephalitis.

    Shen Ying Zhang;Shen Ying Zhang;Emmanuelle Jouanguy;Emmanuelle Jouanguy;Sophie Ugolini;Asma Smahi

  • The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

    András Kotschy;Zoltán Szlavik;James Murray;James Davidson

  • Stimulation of homologous recombination through targeted cleavage by chimeric nucleases.

    Marina Bibikova;Dana Carroll;David J. Segal;Jonathan K. Trautman

  • Toward controlling gene expression at will: Specific regulation of the erbB-2/HER-2 promoter by using polydactyl zinc finger proteins constructed from modular building blocks

    Roger R. Beerli;David J. Segal;Birgit Dreier;Carlos F. Barbas

  • Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases.

    Michal Szczepek;Vincent Brondani;Janine Büchel;Luis Serrano

  • Toward controlling gene expression at will: selection and design of zinc finger domains recognizing each of the 5'-GNN-3' DNA target sequences.

    David J. Segal;Birgit Dreier;Roger R. Beerli;Carlos F. Barbas

  • Transcriptional regulation in the immune system: all roads lead to AP-1.

    Victoria C. Foletta;David H. Segal;Donna R. Cohen

  • Design of polydactyl zinc-finger proteins for unique addressing within complex genomes

    Qiang Liu;David J. Segal;Jayant B. Ghiara;Carlos F. Barbas

  • Methods and compositions for using zinc finger endonucleases to enhance homologous recombination

    Monika Liljedahl;Simon Eric Aspland;David J. Segal

  • Development of zinc finger domains for recognition of the 5'-ANN-3' family of DNA sequences and their use in the construction of artificial transcription factors.

    Birgit Dreier;Roberta P. Fuller;David J. Segal;Caren V. Lund

  • Keep your fingers off my DNA: Protein-protein interactions mediated by C2H2 zinc finger domains

    Kathryn J. Brayer;David J. Segal

  • SRA- and SET-domain-containing proteins link RNA polymerase V occupancy to DNA methylation

    Lianna M. Johnson;Jiamu Du;Christopher J. Hale;Sylvain Bischof

  • The BCL2 selective inhibitor venetoclax induces rapid onset apoptosis of CLL cells in patients via a TP53-independent mechanism.

    Mary Ann Anderson;Mary Ann Anderson;Mary Ann Anderson;Jing Deng;John F. Seymour;John F. Seymour;Constantine Tam;Constantine Tam

  • Evaluation of a modular strategy for the construction of novel polydactyl zinc finger DNA-binding proteins.

    David J. Segal;Roger R. Beerli;Pilar Blancafort;Birgit Dreier

  • A genome-wide analysis of Cas9 binding specificity using ChIP-seq and targeted sequence capture

    Henriette O'Geen;Isabelle M. Henry;Mital S. Bhakta;Joshua F. Meckler

  • Targeted DNA demethylation of the Arabidopsis genome using the human TET1 catalytic domain

    Javier Gallego-Bartolomé;Jason Gardiner;Wanlu Liu;Ashot Papikian

  • Designing Transcription Factor Architectures for Drug Discovery

    Pilar Blancafort;David J. Segal;Carlos F. Barbas

  • Design, construction and in vitro testing of zinc finger nucleases

    Dana Carroll;J Jason Morton;Kelly J Beumer;David J Segal;David J Segal

  • Insights into the molecular recognition of the 5'-GNN-3' family of DNA sequences by zinc finger domains.

    Birgit Dreier;David J Segal;Carlos F Barbas

  • Custom Zinc-Finger Nucleases for Use in Human Cells

    Stephen Alwin;Maja B. Gere;Eva Guhl;Karin Effertz

Frequent Co-Authors

David C. S. Huang
David C. S. Huang Walter and Eliza Hall Institute of Medical Research
Carlos F. Barbas
Carlos F. Barbas Scripps Research Institute
Guillaume Lessene
Guillaume Lessene Walter and Eliza Hall Institute of Medical Research
Marco J. Herold
Marco J. Herold Walter and Eliza Hall Institute of Medical Research
Andreas Strasser
Andreas Strasser Walter and Eliza Hall Institute of Medical Research
Andrew W. Roberts
Andrew W. Roberts Walter and Eliza Hall Institute of Medical Research
Joel P. Mackay
Joel P. Mackay University of Sydney
Peter E. Czabotar
Peter E. Czabotar Walter and Eliza Hall Institute of Medical Research
Dana Carroll
Dana Carroll University of Utah
Luis G. Carvajal-Carmona
Luis G. Carvajal-Carmona University of California, Davis

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