D-Index & Metrics Best Publications

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Genetics and Molecular Biology D-index 58 Citations 11,616 122 World Ranking 2644 National Ranking 1282

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • DNA
  • Enzyme

His primary areas of investigation include Zinc finger, Genetics, DNA, Protein–DNA interaction and Zinc finger nuclease. His Zinc finger research incorporates elements of Protein structure, Protein engineering and Phage display. His Genetics study frequently links to other fields, such as Computational biology.

His DNA research is classified as research in Biochemistry. His work deals with themes such as DNA-binding domain, LIM domain and RING finger domain, which intersect with Protein–DNA interaction. David J. Segal works mostly in the field of Zinc finger nuclease, limiting it down to concerns involving Homologous recombination and, occasionally, Cleavage.

His most cited work include:

  • TLR3 deficiency in patients with herpes simplex encephalitis. (839 citations)
  • Endorphins: profound behavioral effects in rats suggest new etiological factors in mental illness. (754 citations)
  • Stimulation of homologous recombination through targeted cleavage by chimeric nucleases. (533 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of study are Zinc finger, Genetics, Computational biology, DNA and Cancer research. His study in Zinc finger is interdisciplinary in nature, drawing from both Molecular biology and DNA sequencing. His Computational biology study integrates concerns from other disciplines, such as Genome editing, Cas9, CRISPR, RNA and Binding domain.

David J. Segal interconnects Cell culture, Apoptosis, MCL1, Leukemia and Multiple myeloma in the investigation of issues within Cancer research. His research integrates issues of Myeloid Cell Leukemia Sequence 1 Protein, Cancer and Pharmacology in his study of MCL1. His study looks at the relationship between Zinc finger nuclease and topics such as Homologous recombination, which overlap with Endonuclease.

He most often published in these fields:

  • Zinc finger (31.22%)
  • Genetics (28.29%)
  • Computational biology (22.93%)

What were the highlights of his more recent work (between 2017-2021)?

  • Cancer research (24.39%)
  • Computational biology (22.93%)
  • CRISPR (7.80%)

In recent papers he was focusing on the following fields of study:

His scientific interests lie mostly in Cancer research, Computational biology, CRISPR, Gene and Genome editing. His Cancer research research includes themes of Cell culture, Apoptosis, Bortezomib, Venetoclax and MCL1. In his study, which falls under the umbrella issue of MCL1, Chemotherapy and Pharmacology is strongly linked to Leukemia.

His Gene study is associated with Genetics. His Cas9 research is multidisciplinary, relying on both Protein engineering, Comparative genomics and Zinc finger, Artificial transcription factor. He has researched Zinc finger in several fields, including Sequence and Function.

Between 2017 and 2021, his most popular works were:

  • Targeted DNA demethylation of the Arabidopsis genome using the human TET1 catalytic domain (89 citations)
  • Enhancing venetoclax activity in acute myeloid leukemia by co-targeting MCL1 (77 citations)
  • Enhancing venetoclax activity in acute myeloid leukemia by co-targeting MCL1 (77 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • DNA
  • Enzyme

David J. Segal mostly deals with Cancer research, Regulation of gene expression, MCL1, Myeloid and Venetoclax. He has included themes like Arthritis, Inflammation, Interferon, Ikaros Transcription Factor and Programmed cell death in his Cancer research study. His studies deal with areas such as Cell, Apoptosis, Transcription factor, Downregulation and upregulation and IKZF3 as well as Regulation of gene expression.

His MCL1 study combines topics in areas such as Cytarabine, Leukemia, Myeloid leukemia, Chemotherapy and Pharmacology. His Myeloid research is multidisciplinary, incorporating elements of Myeloid Cell Leukemia Sequence 1 Protein, Idarubicin, Hematology and Bone marrow.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Endorphins: profound behavioral effects in rats suggest new etiological factors in mental illness.

Floyd Bloom;David Segal;Nicholas Ling;Roger Guillemin.
Science (1976)

1221 Citations

TLR3 deficiency in patients with herpes simplex encephalitis.

Shen Ying Zhang;Shen Ying Zhang;Emmanuelle Jouanguy;Emmanuelle Jouanguy;Sophie Ugolini;Asma Smahi.
Science (2007)

1023 Citations

Stimulation of homologous recombination through targeted cleavage by chimeric nucleases.

Marina Bibikova;Dana Carroll;David J. Segal;Jonathan K. Trautman.
Molecular and Cellular Biology (2001)

709 Citations

Toward controlling gene expression at will: Specific regulation of the erbB-2/HER-2 promoter by using polydactyl zinc finger proteins constructed from modular building blocks

Roger R. Beerli;David J. Segal;Birgit Dreier;Carlos F. Barbas.
Proceedings of the National Academy of Sciences of the United States of America (1998)

651 Citations

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

András Kotschy;Zoltán Szlavik;James Murray;James Davidson.
Nature (2016)

623 Citations

Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases.

Michal Szczepek;Vincent Brondani;Janine Büchel;Luis Serrano.
Nature Biotechnology (2007)

587 Citations

Toward controlling gene expression at will: selection and design of zinc finger domains recognizing each of the 5'-GNN-3' DNA target sequences.

David J. Segal;Birgit Dreier;Roger R. Beerli;Carlos F. Barbas.
Proceedings of the National Academy of Sciences of the United States of America (1999)

562 Citations

Transcriptional regulation in the immune system: all roads lead to AP-1.

Victoria C. Foletta;David H. Segal;Donna R. Cohen.
Journal of Leukocyte Biology (1998)

441 Citations

Design of polydactyl zinc-finger proteins for unique addressing within complex genomes

Qiang Liu;David J. Segal;Jayant B. Ghiara;Carlos F. Barbas.
Proceedings of the National Academy of Sciences of the United States of America (1997)

407 Citations

Development of Zinc Finger Domains for Recognition of the 5′-CNN-3′ Family DNA Sequences and Their Use in the Construction of Artificial Transcription Factors *

Birgit Dreier;Roberta P. Fuller;David J. Segal;Caren V. Lund.
Journal of Biological Chemistry (2001)

374 Citations

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Profile was last updated on December 6th, 2021.
Research.com Ranking is based on data retrieved from the Microsoft Academic Graph (MAG).
The ranking d-index is inferred from publications deemed to belong to the considered discipline.

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