His primary areas of investigation include Biochemistry, Protein structure, Genetics, Zinc finger and Plasma protein binding. Biochemistry connects with themes related to Biophysics in his study. The concepts of his Protein structure study are interwoven with issues in Hydrophobin, Stereochemistry and Fungal protein.
Joel P. Mackay combines subjects such as DNA-binding protein, SIAH2, DNA ligase, Cell biology and Composite material with his study of Zinc finger. Joel P. Mackay has included themes like Affinities, Nuclear protein and Computational biology in his DNA-binding protein study. His Plasma protein binding study incorporates themes from SIAH1, Electron transport chain and Ubiquitin.
Joel P. Mackay focuses on Cell biology, Biochemistry, Zinc finger, Genetics and Protein structure. His study in Cell biology is interdisciplinary in nature, drawing from both Transcription factor, Chromatin, Histone, Nucleosome and Molecular biology. Joel P. Mackay focuses mostly in the field of Biochemistry, narrowing it down to matters related to Biophysics and, in some cases, Binding site.
In his research, Computational biology is intimately related to RNA, which falls under the overarching field of Zinc finger. His biological study spans a wide range of topics, including Crystallography, Nuclear magnetic resonance spectroscopy, Stereochemistry and Protein–protein interaction. His work carried out in the field of LIM domain brings together such families of science as Binding domain and LMO2.
His main research concerns Cell biology, Nucleosome, Mi-2/NuRD complex, Chromatin and Bromodomain. His Chromatin study integrates concerns from other disciplines, such as Protein structure, Histone, Epigenetics and Protein domain. His Protein structure research is multidisciplinary, relying on both Steric effects, Plasma protein binding, Hydrogen bond and Protein–protein interaction.
His studies in Bromodomain integrate themes in fields like Transcription factor, Computational biology and Binding pocket. In his study, Zinc finger is inextricably linked to Sequence, which falls within the broad field of Fusion protein. The DNA study combines topics in areas such as Biophysics and Binding site.
Joel P. Mackay mainly investigates Genetics, Cell biology, Mi-2/NuRD complex, Histone and Nucleosome. His work on CRISPR, Point mutation and Zinc finger as part of general Genetics study is frequently connected to Human genome, therefore bridging the gap between diverse disciplines of science and establishing a new relationship between them. His research integrates issues of Chemokine, Sulfation and Native chemical ligation in his study of Cell biology.
His research in Histone intersects with topics in Chromatin, Plasma protein binding, Protein structure and Protein–protein interaction. As a member of one scientific family, he mostly works in the field of Nucleosome, focusing on Chromodomain and, on occasion, Function. His Chromatin remodeling study improves the overall literature in Transcription factor.
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Zinc fingers are sticking together
Joel P. Mackay;Merlin Crossley.
Trends in Biochemical Sciences (1998)
Sticky fingers: zinc-fingers as protein-recognition motifs
Roland Gamsjaeger;Chu Kong Liew;Fionna E. Loughlin;Merlin Crossley.
Trends in Biochemical Sciences (2007)
Mutations in Cardiac T-Box Factor Gene TBX20 Are Associated with Diverse Cardiac Pathologies, Including Defects of Septation and Valvulogenesis and Cardiomyopathy
Edwin P. Kirk;Edwin P. Kirk;Edwin P. Kirk;Margaret Sunde;Mauro W. Costa;Mauro W. Costa;Scott A Rankin.
American Journal of Human Genetics (2007)
Cardiac hypertrophy and histone deacetylase–dependent transcriptional repression mediated by the atypical homeodomain protein Hop
Hyun Kook;John J. Lepore;Aaron D. Gitler;Min Min Lu.
Journal of Clinical Investigation (2003)
Transcriptional cofactors of the FOG family interact with GATA proteins by means of multiple zinc fingers
Archa H. Fox;Chu Liew;Melissa Holmes;Kasper Kowalski.
The EMBO Journal (1999)
Use of altered specificity mutants to probe a specific protein-protein interaction in differentiation: the GATA-1:FOG complex.
John D Crispino;John D Crispino;Maya B Lodish;Maya B Lodish;Joel P MacKay;Stuart H Orkin;Stuart H Orkin.
Molecular Cell (1999)
Hop is an unusual homeobox gene that modulates cardiac development.
Fabian Chen;Hyun Kook;Rita Milewski;Aaron D. Gitler.
Structural basis for rodlet assembly in fungal hydrophobins
Ahy Kwan;RD Winefield;M Sunde;JM Matthews.
Proceedings of the National Academy of Sciences of the United States of America (2006)
Structural analysis of hydrophobins
Margaret Sunde;Ann H.Y. Kwan;Matthew D. Templeton;Ross E. Beever.
Glycopeptide antibiotic activity and the possible role of dimerization : A model for biological signaling
Joel P. Mackay;Ute Gerhard;Daniel A. Beauregard;Dudley H. Williams.
Journal of the American Chemical Society (1994)
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