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Genetics

D-Index
68
Citations
14376
World Ranking
2447
National Ranking
84

Overview

Merlin Crossley is affiliated with the University of New South Wales in Australia. Their research spans multiple areas within the broad disciplines of Biochemistry, Genetics, and Molecular Biology, with significant contributions also related to Medicine.

Their main fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these fields, Crossley has focused on several subfields:

  • Molecular Biology
  • Genetics
  • Pediatrics, Perinatology and Child Health
  • Physiology
  • Business and International Management

Their research topics cover a range of subjects relevant to genetic and molecular regulation, with particular emphasis on hemoglobin-related disorders and genetic editing:

  • Hemoglobinopathies and Related Disorders
  • Epigenetics and DNA Methylation
  • Prenatal Screening and Diagnostics
  • RNA modifications and cancer
  • CRISPR and Genetic Engineering
  • Genomics and Chromatin Dynamics
  • Bioinformatics and Genomic Networks

Merlin Crossley has published multiple recent papers, illustrating their active engagement with current genetic and molecular research issues. Selected publications include:

  • Global citizen deliberation on genome editing, 2020, Science
  • ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression, 2020, Molecular Cell
  • Identification of novel HPFH-like mutations by CRISPR base editing that elevate the expression of fetal hemoglobin, 2022, eLife
  • Potent and uniform fetal hemoglobin induction via base editing, 2023, Nature Genetics
  • Disrupting the adult globin promoter alleviates promoter competition and reactivates fetal globin gene expression, 2022, Blood

The venues where Crossley frequently publishes reflect a focus on molecular biology, genetics, and hematology. The most common publication venues are:

  • BioEssays
  • Nature Genetics
  • Blood
  • Nature Communications
  • Journal of Biological Chemistry

Collaboration is a notable component of Crossley's research activity. Frequent co-authors include:

  • Luís Aragón
  • Mohan Babu
  • Ronald Berezney
  • Hannah Correia
  • Thomas Cremer

Best Publications

  • FOG, a Multitype Zinc Finger Protein, Acts as a Cofactor for Transcription Factor GATA-1 in Erythroid and Megakaryocytic Differentiation

    Alice P Tsang;Jane E Visvader;C.Alexander Turner;Yuko Fujiwara;Yuko Fujiwara

  • Modification with SUMO. A role in transcriptional regulation.

    Alexis Verger;José Perdomo;Merlin Crossley

  • Zinc fingers are sticking together

    Joel P. Mackay;Merlin Crossley

  • Sticky fingers: zinc-fingers as protein-recognition motifs

    Roland Gamsjaeger;Chu Kong Liew;Fionna E. Loughlin;Merlin Crossley

  • Krüppel-like transcription factors: a functional family.

    Richard Pearson;Jacqueline Fleetwood;Sally Eaton;Merlin Crossley

  • Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators.

    Jeremy Turner;Merlin Crossley

  • Mammalian Krüppel-like transcription factors: more than just a pretty finger.

    Jeremy Turner;Merlin Crossley

  • Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin

    Takeshi Masuda;Xin Wang;Manami Maeda;Matthew C. Canver

  • Transcriptional cofactors of the FOG family interact with GATA proteins by means of multiple zinc fingers

    Archa H. Fox;Chu Liew;Melissa Holmes;Kasper Kowalski

  • ISOLATION AND CHARACTERIZATION OF THE CDNA ENCODING BKLF/TEF-2, A MAJOR CACCC-BOX-BINDING PROTEIN IN ERYTHROID CELLS AND SELECTED OTHER CELLS

    Merlin Crossley;Emma Whitelaw;Andrew Perkins;Greg Williams

  • Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding

    Gabriella E. Martyn;Beeke Wienert;Lu Yang;Manan Shah

  • The CtBP family: enigmatic and enzymatic transcriptional co-repressors.

    Jeremy Turner;Merlin Crossley

  • X-linked thrombocytopenia caused by a novel mutation of GATA-1.

    Michele G. Mehaffey;Anthea L. Newton;Manish J. Gandhi;Merlin Crossley

  • Self-association of the erythroid transcription factor GATA-1 mediated by its zinc finger domains.

    M Crossley;M Merika;S H Orkin

  • Targeted Disruption of the Basic Krüppel-Like Factor Gene (Klf3) Reveals a Role in Adipogenesis

    Nancy Sue;Briony H. A. Jack;Sally A. Eaton;Richard C. M. Pearson

  • Controlling the size of lipid droplets: lipid and protein factors.

    Hongyuan Yang;Anne Galea;Vladimir Sytnyk;Merlin Crossley

  • Human Krüppel-like Factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription

    Jane van Vliet;Jeremy Turner;Merlin Crossley

  • The C-terminal zinc finger of GATA-1 or GATA-2 is sufficient to induce megakaryocytic differentiation of an early myeloid cell line.

    J E Visvader;M Crossley;J Hill;S H Orkin

  • Disruption of a C/EBP binding site in the factor IX promoter is associated with haemophilia B.

    Merlin Crossley;George G. Brownlee

  • Recovery from hemophilia B Leyden: an androgen-responsive element in the factor IX promoter

    M Crossley;M Ludwig;KM Stowell;P De Vos

Frequent Co-Authors

Joel P. Mackay
Joel P. Mackay University of Sydney
Andrew C. Perkins
Andrew C. Perkins Monash University
Stuart H. Orkin
Stuart H. Orkin Harvard University
Paul Flicek
Paul Flicek The Jackson Laboratory
Duncan T. Odom
Duncan T. Odom University of Cambridge
Michael D. Wilson
Michael D. Wilson University of Toronto
Gerd A. Blobel
Gerd A. Blobel Children's Hospital of Philadelphia
John C. Marioni
John C. Marioni European Bioinformatics Institute
Mitchell J. Weiss
Mitchell J. Weiss St. Jude Children's Research Hospital
Glenn F. King
Glenn F. King University of Queensland

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