World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
78
Citations
16619
World Ranking
4652
National Ranking
349

Overview

David A. Lee is affiliated with Queen Mary University of London in the United Kingdom. Their research spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a particular focus on several subfields including Cell Biology, Immunology and Allergy, Molecular Biology, Ophthalmology, and Endocrine and Autonomic Systems.

The scientist's work addresses key topics such as Cell Adhesion Molecules Research, Cellular Mechanics and Interactions, Circadian Rhythm and Melatonin, Proteoglycans and Glycosaminoglycans Research, Glycosylation and Glycoproteins Research, Cancer Cells and Metastasis, and Estrogen and Related Hormone Effects.

David A. Lee has published in a range of scientific venues, frequently contributing to Frontiers in Cell and Developmental Biology, Nature Materials, Cancers, Digital Health, and Cell.

Their recent papers include:

  • Syndecan-4 tunes cell mechanics by activating the kindlin-integrin-RhoA pathway, 2020, Nature Materials
  • GPER Activation Inhibits Cancer Cell Mechanotransduction and Basement Membrane Invasion via RhoA, 2020, Cancers
  • G Protein-Coupled Estrogen Receptor Regulates Actin Cytoskeleton Dynamics to Impair Cell Polarization, 2020, Frontiers in Cell and Developmental Biology
  • Patients with floaters: Answers from virtual assistants and large language models, 2024, Digital Health
  • Mast cells regulate the brain-dura interface and CSF dynamics, 2025, Cell

Collaborations have been an important aspect of their work, with frequent co-authors including Stephen D. Thorpe, Ernesto Cortés, Dariusz Lachowski, Alistair Rice, and Armando E. del Río Hernández.

Best Publications

  • Predicting protein function from sequence and structure

    David Lee;Oliver Redfern;Christine Orengo

  • Compressive strains at physiological frequencies influence the metabolism of chondrocytes seeded in agarose.

    David A. Lee;Dan L. Bader

  • CATH: comprehensive structural and functional annotations for genome sequences

    Ian Sillitoe;Tony E. Lewis;Alison L. Cuff;Sayoni Das

  • An expanded evaluation of protein function prediction methods shows an improvement in accuracy

    Yuxiang Jiang;Tal Ronnen Oron;Wyatt T. Clark;Asma R. Bankapur

  • CATH: an expanded resource to predict protein function through structure and sequence.

    Natalie L. Dawson;Tony E. Lewis;Sayoni Das;Jonathan G. Lees

  • Quantification of Sulfated Glycosaminoglycans in Chondrocyte/Alginate Cultures, by Use of 1,9-Dimethylmethylene Blue

    Brian O. Enobakhare;Dan L. Bader;David A. Lee

  • The CATH Domain Structure Database and related resources Gene3D and DHS provide comprehensive domain family information for genome analysis

    Frances M. G. Pearl;Annabel E. Todd;Ian Sillitoe;Mark Dibley

  • The metabolism of human mesenchymal stem cells during proliferation and differentiation

    Girish Pattappa;Hannah K. Heywood;Joost D. de Bruijn;David A. Lee

  • Crosslinking density influences chondrocyte metabolism in dynamically loaded photocrosslinked poly(ethylene glycol) hydrogels.

    Stephanie J. Bryant;Tina T. Chowdhury;David A. Lee;Dan L. Bader

  • An expanded evaluation of protein function prediction methods shows an improvement in accuracy

    Yuxiang Jiang;Tal Ronnen Oron;Wyatt T Clark;Asma R Bankapur

  • An investigation into the effects of the hierarchical structure of tendon fascicles on micromechanical properties.

    H R C Screen;D A Lee;D L Bader;J C Shelton

  • Assigning genomic sequences to CATH.

    Frances M. G. Pearl;David A. Lee;James E. Bray;Ian Sillitoe

  • Crosslinking density influences the morphology of chondrocytes photoencapsulated in PEG hydrogels during the application of compressive strain.

    Stephanie J Bryant;Kristi S Anseth;Kristi S Anseth;David A Lee;Dan L Bader

  • Studies of Drug Utilization

    Björn Wettermark;Vera Vlahović-Palčevski;David Lee;Ulf Bergman

  • Dry needle stimulation of myofascial trigger points evokes segmental anti-nociceptive effects.

    John Z Srbely;James P Dickey;David Lee;Mark Lowerison

  • The semantics of just

    David Lee

  • The influence of mechanical loading on isolated chondrocytes seeded in agarose constructs.

    David A. Lee;Takashi Noguchi;Stephen P. Frean;Peter Lees

  • Mutations in the CYLD gene in Brooke–Spiegler Syndrome, Familial Cylindromatosis, and Multiple Familial Trichoepithelioma: Lack of Genotype–Phenotype Correlation

    Sarah Bowen;Melissa Gill;David A. Lee;Galen Fisher

  • Dynamic compressive strain influences chondrogenic gene expression in human mesenchymal stem cells.

    Jonathan J Campbell;David A Lee;Dan L Bader

  • Additional file 1 of An expanded evaluation of protein function prediction methods shows an improvement in accuracy

    Yuxiang Jiang;Tal Ronnen Oron;Wyatt T. Clark;Asma R. Bankapur

Frequent Co-Authors

Christine A. Orengo
Christine A. Orengo University College London
Ian Sillitoe
Ian Sillitoe University College London
Janet M. Thornton
Janet M. Thornton European Bioinformatics Institute
Robert L. Mauck
Robert L. Mauck University of Pennsylvania
Christophe Dessimoz
Christophe Dessimoz University College London
Christopher S. Chen
Christopher S. Chen Boston University
Kristi S. Anseth
Kristi S. Anseth University of Colorado Boulder
Toni Gabaldón
Toni Gabaldón Institució Catalana de Recerca i Estudis Avançats
Burkhard Rost
Burkhard Rost Technical University of Munich
George E. Bentley
George E. Bentley University of California, Berkeley

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