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Biology and Biochemistry

D-Index
49
Citations
9571
World Ranking
17977
National Ranking
7357

Overview

Chen-Yong Lin is a researcher affiliated with Georgetown University in the United States. The work centers on various aspects of biochemistry, genetics, molecular biology, and medicine, with a focus on cellular and molecular mechanisms.

The main fields of study covered by Chen-Yong Lin include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Subfields of study emphasize:

  • Cell Biology
  • Molecular Biology
  • Hematology
  • Cancer Research
  • Immunology

The primary research topics are:

  • Protease and Inhibitor Mechanisms
  • Blood Coagulation and Thrombosis Mechanisms
  • Skin and Cellular Biology Research
  • Proteoglycans and glycosaminoglycans research
  • Cell Adhesion Molecules Research
  • Coagulation, Bradykinin, Polyphosphates, and Angioedema
  • Complement system in diseases

Among recent publications attributed to or involving Chen-Yong Lin are:

  • "Rapid Assessment of Surface Markers on Cancer Cells Using Immuno-Magnetic Separation and Multi-frequency Impedance Cytometry for Targeted Therapy," 2020, Scientific Reports
  • "Differential subcellular distribution renders HAI-2 a less effective protease inhibitor than HAI-1 in the control of extracellular matriptase proteolytic activity," 2020, Genes & Diseases
  • "The spatiotemporal control of human matriptase action on its physiological substrates: a case against a direct role for matriptase proteolytic activity in profilaggrin processing and desquamation," 2020, Human Cell
  • "Matriptase and prostasin proteolytic activities are differentially regulated in normal and wounded skin," 2020, Human Cell
  • "Mild acidity likely accelerates the physiological matriptase autoactivation process: a comparative study between spontaneous and acid-induced matriptase zymogen activation," 2020, Human Cell

Frequent co-authors collaborating with Chen-Yong Lin include:

  • Michael D. Johnson
  • Jehng-Kang Wang
  • Robert B. Barndt
  • Nanxi Huang
  • Dajun D. Lu

Chen-Yong Lin has published multiple articles in the following venues:

  • Human Cell
  • Human Molecular Genetics
  • Scientific Reports
  • Genes & Diseases
  • Journal of Clinical Investigation

Best Publications

  • Activation of Hepatocyte Growth Factor and Urokinase/Plasminogen Activator by Matriptase, an Epithelial Membrane Serine Protease

    Sheau-Ling Lee;Robert B. Dickson;Chen-Yong Lin

  • Immunosuppressive and Anti-Angiogenic Sphingosine 1-phosphate receptor-1 Agonists Induce Ubiquitinylation and Proteasomal Degradation of the Receptor

    Myat Lin Oo;Shobha Thangada;Ming-Tao Wu;Catherine H. Liu

  • A potential marker protease of invasiveness, seprase, is localized on invadopodia of human malignant melanoma cells

    Wayne L. Monsky;Chen Yong Lin;Atsuko Aoyama;Thomas Kelly

  • Tissue microarray analysis of hepatocyte growth factor/Met pathway components reveals a role for Met, matriptase, and hepatocyte growth factor activator inhibitor 1 in the progression of node-negative breast cancer.

    Jung Y. Kang;Marisa Dolled-Filhart;Idris Tolgay Ocal;Baljit Singh

  • Purification and characterization of a complex containing matriptase and a Kunitz-type serine protease inhibitor from human milk.

    Chen-Yong Lin;Joanna Anders;Michael Johnson;Robert B. Dickson

  • Molecular Cloning of cDNA for Matriptase, a Matrix-degrading Serine Protease with Trypsin-like Activity

    Chen-Yong Lin;Joanna Anders;Michael Johnson;Qingxiang Amy Sang

  • Binding and Localization of Mr 72,000 Matrix Metalloproteinase at Cell Surface Invadopodia

    Wayne L. Monsky;Thomas Kelly;Chen Yong Lin;Yunyun Yeh

  • Evidence for a Matriptase-Prostasin Proteolytic Cascade Regulating Terminal Epidermal Differentiation

    Sarah Netzel-Arnett;Brooke M. Currie;Roman Szabo;Chen Yong Lin

  • Expression of the serine protease matriptase and its inhibitor HAI-1 in epithelial ovarian cancer: correlation with clinical outcome and tumor clinicopathological parameters.

    Michael D Oberst;Michael D Johnson;Robert B Dickson;Chen-Yong Lin

  • Matriptase and HAI-1 Are Expressed by Normal and Malignant Epithelial Cells in Vitro and in Vivo

    Michael Oberst;Joanna Anders;Bin Xie;Baljit Singh

  • The activation of matriptase requires its noncatalytic domains, serine protease domain, and its cognate inhibitor.

    Michael D. Oberst;Cicely A. Williams;Robert B. Dickson;Michael D. Johnson

  • Membrane-anchored serine protease matriptase regulates epithelial barrier formation and permeability in the intestine

    Marguerite S. Buzza;Sarah Netzel-Arnett;Terez Shea-Donohue;Aiping Zhao

  • Prometastatic Effect ofN-Acetylglucosaminyltransferase V Is Due to Modification and Stabilization of Active Matriptase by Adding β1–6 GlcNAc Branching

    Shinji Ihara;Eiji Miyoshi;Jeong Heon Ko;Kohei Murata

  • HAI-1 regulates activation and expression of matriptase, a membrane-bound serine protease.

    Michael D. Oberst;Li-Yuan L. Chen;Ken-Ichi Kiyomiya;Cicely A. Williams

  • Regulation of the activity of matriptase on epithelial cell surfaces by a blood-derived factor

    Christelle Benaud;Robert B. Dickson;Chen-Yong Lin

  • Characterization of Matriptase expression in normal human tissues

    Michael D. Oberst;Baljit Singh;Metin Ozdemirli;Robert B. Dickson

  • TMPRSS2, a Serine Protease Expressed in the Prostate on the Apical Surface of Luminal Epithelial Cells and Released into Semen in Prostasomes, Is Misregulated in Prostate Cancer Cells

    Ya-Wen Chen;Ming-Shyue Lee;Amanda Lucht;Feng-Pai Chou

  • A Novel Biomarker for Staging Human Prostate Adenocarcinoma: Overexpression of Matriptase with Concomitant Loss of its Inhibitor, Hepatocyte Growth Factor Activator Inhibitor-1

    Mohammad Saleem;Vaqar Mustafa Adhami;Weixiong Zhong;B. Jack Longley

  • Local protease signaling contributes to neural tube closure in the mouse embryo.

    Eric Camerer;Eric Camerer;Adrian Barker;Daniel N. Duong;Rajkumar Ganesan

  • Characterization of a Novel, Membrane-bound, 80-kDa Matrix-degrading Protease from Human Breast Cancer Cells MONOCLONAL ANTIBODY PRODUCTION, ISOLATION, AND LOCALIZATION

    Chen-Yong Lin;Jehng-Kang Wang;Jeff Torri;Li Dou

Frequent Co-Authors

Robert B. Dickson
Robert B. Dickson Georgetown University Medical Center
Michael D. Johnson
Michael D. Johnson Georgetown University
Michael D. Johnson
Michael D. Johnson University of Michigan–Ann Arbor
Hiroaki Kataoka
Hiroaki Kataoka University of Miyazaki
Thomas H. Bugge
Thomas H. Bugge National Institutes of Health
Kaoru Miyazaki
Kaoru Miyazaki Yokohama City University
Timothy Hla
Timothy Hla Harvard University
Richard L. Eckert
Richard L. Eckert University of Maryland, Baltimore
Eiji Miyoshi
Eiji Miyoshi Osaka University
Naoyuki Taniguchi
Naoyuki Taniguchi Osaka University

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