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Detlev Schindler

Detlev Schindler

D-Index & Metrics

Genetics

D-Index
65
Citations
14770
World Ranking
2705
National Ranking
194

Overview

Detlev Schindler is affiliated with the University of Würzburg in Germany. Their research spans across the fields of Biochemistry, Genetics and Molecular Biology, with additional focus on Medicine. The primary subfields they have contributed to include Molecular Biology, Genetics, Cancer Research, Cell Biology, and Oncology.

The core topics covered in Schindler's research involve DNA Repair Mechanisms, Carcinogens and Genotoxicity Assessment, Microtubule and mitosis dynamics, CRISPR and Genetic Engineering, Ubiquitin and proteasome pathways, Cancer-related Molecular Pathways, and Genomics and Chromatin Dynamics.

Among their recent scientific papers are the following:

  • Integration of proteomics with genomics and transcriptomics increases the diagnostic rate of Mendelian disorders, 2021, bioRxiv (Cold Spring Harbor Laboratory)
  • MRE11-dependent instability in mitochondrial DNA fork protection activates a cGAS immune signaling pathway, 2021, Science Advances
  • A novel classification of hematologic conditions in patients with Fanconi anemia, 2021, Haematologica
  • Compromised repair of radiation-induced DNA double-strand breaks in Fanconi anemia fibroblasts in G2, 2020, DNA Repair
  • RFWD3 promotes ZRANB3 recruitment to regulate the remodeling of stalled replication forks, 2023, The Journal of Cell Biology

Frequent collaborators include Reinhard Kalb, Sunetra Roy, Katharina Schlacher, Elisabeth Graf, and Karl-Heinz Tomaszowski.

Schindler's work is frequently published in venues such as bioRxiv (Cold Spring Harbor Laboratory), Journal of Clinical Investigation, Genetics in Medicine, Nature Communications, and Familial Cancer.

Best Publications

  • Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene

    Alfons Meindl;Heide Hellebrand;Constanze Wiek;Verena Erven

  • Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer

    Sarah Reid;Detlev Schindler;Helmut Hanenberg;Helmut Hanenberg;Karen Barker

  • The Fanconi anaemia group G gene FANCG is identical with XRCC9.

    de Winter Jp;Waisfisz Q;Rooimans Ma;van Berkel Cg

  • Mutation of the RAD51C gene in a Fanconi anemia-like disorder

    Fiona Vaz;Helmut Hanenberg;Helmut Hanenberg;Beatrice Schuster;Karen Barker

  • The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia.

    Orna Levran;Claire Attwooll;Rashida T Henry;Kelly L Milton

  • Mutations in the Pericentrin (PCNT) Gene Cause Primordial Dwarfism

    Anita Rauch;Christian T. Thiel;Detlev Schindler;Ursula Wick

  • SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype

    C. Stoepker;K. Hain;B. Schuster;Y. Hilhorst-Hofstee

  • Mutations in ERCC4, encoding the DNA-repair endonuclease XPF, cause Fanconi anemia.

    Massimo Bogliolo;Beatrice Schuster;Chantal Stoepker;Burak Derkunt

  • Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder.

    Regina Waltes;Reinhard Kalb;Magtouf Gatei;Amanda W. Kijas

  • Characterization of ATM Gene Mutations in 66 Ataxia Telangiectasia Families

    Natalia Sandoval;Matthias Platzer;André Rosenthal;Thilo Dörk

  • A histone-fold complex and FANCM form a conserved DNA remodeling complex to maintain genome stability

    Zhijiang Yan;Mathieu Delannoy;Chen Ling;Danielle Daee

  • A recurrent 11q aberration pattern characterizes a subset of MYC-negative high-grade B-cell lymphomas resembling Burkitt lymphoma.

    Itziar Salaverria;Itziar Salaverria;Idoia Martin-Guerrero;Idoia Martin-Guerrero;Rabea Wagener;Markus Kreuz

  • Reverse mosaicism in Fanconi anemia: natural gene therapy via molecular self-correction

    M Gross;H Hanenberg;S Lobitz;R Friedl

  • Biallelic mutations in the ubiquitin ligase RFWD3 cause Fanconi anemia

    Kerstin Knies;Shojiro Inano;María J. Ramírez;Masamichi Ishiai

  • BrdU-Hoechst flow cytometry: a unique tool for quantitative cell cycle analysis.

    P.S. Rabinovitch;M. Kubbies;Y.C. Chen;D. Schindler

  • FAAP100 is essential for activation of the Fanconi anemia-associated DNA damage response pathway.

    Chen Ling;Masamichi Ishiai;Abdullah Mahmood Ali;Annette L Medhurst

  • RFWD3-Mediated Ubiquitination Promotes Timely Removal of Both RPA and RAD51 from DNA Damage Sites to Facilitate Homologous Recombination.

    Shojiro Inano;Koichi Sato;Yoko Katsuki;Wataru Kobayashi

  • Genotype-phenotype correlations in Fanconi anemia.

    Kornelia Neveling;Daniela Endt;Holger Hoehn;Detlev Schindler

  • Fanconi anemia mutation causes cellular susceptibility to ambient oxygen.

    D Schindler;H Hoehn

  • Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stability

    Massimo Bogliolo;Alex Lyakhovich;Elsa Callén;Maria Castellà

Frequent Co-Authors

Helmut Hanenberg
Helmut Hanenberg University of Duisburg-Essen
Holger Hoehn
Holger Hoehn University of Würzburg
Jordi Surrallés
Jordi Surrallés Autonomous University of Barcelona
Charlotte M. Niemeyer
Charlotte M. Niemeyer University of Freiburg
Arleen D. Auerbach
Arleen D. Auerbach Rockefeller University
Hans Joenje
Hans Joenje VU University Medical Center
Thilo Dörk
Thilo Dörk Hannover Medical School
Johan P. de Winter
Johan P. de Winter VU University Medical Center
Martin Poot
Martin Poot University of Würzburg
Elsa Callen
Elsa Callen National Institutes of Health

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