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Genetics

D-Index
51
Citations
24606
World Ranking
3823
National Ranking
1651

Overview

Agata Smogorzewska is affiliated with Rockefeller University in the United States and has contributed extensively to the fields of biochemistry, genetics, and molecular biology. Their research primarily focuses on molecular biology, genetics, cancer research, plant science, and oncology, with a significant emphasis on DNA repair mechanisms.

Their work covers a number of key topics including:

  • DNA Repair Mechanisms
  • CRISPR and Genetic Engineering
  • Genomics and Chromatin Dynamics
  • Carcinogens and Genotoxicity Assessment
  • Chromosomal and Genetic Variations
  • Cancer-related Molecular Pathways
  • Epigenetics and DNA Methylation

Agata Smogorzewska has published a variety of research articles in notable scientific venues. Frequent publication outlets include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Blood
  • Nature Structural & Molecular Biology
  • Proceedings of the National Academy of Sciences
  • Clinical Cancer Research

Prominent recent papers authored or co-authored by Smogorzewska include:

  • Cell fitness screens reveal a conflict between LINE-1 retrotransposition and DNA replication, 2020, Nature Structural & Molecular Biology
  • CENP-A chromatin prevents replication stress at centromeres to avoid structural aneuploidy, 2021, Proceedings of the National Academy of Sciences
  • Genomic signature of Fanconi anaemia DNA repair pathway deficiency in cancer, 2022, Nature
  • Distinct roles of BRCA2 in replication fork protection in response to hydroxyurea and DNA interstrand cross-links, 2020, Genes & Development
  • Treatment of Fanconi Anemia-Associated Head and Neck Cancer: Opportunities to Improve Outcomes, 2021, Clinical Cancer Research

The scientist collaborates frequently with colleagues including Francis P. Lach, Moonjung Jung, Settara C. Chandrasekharappa, Arleen D. Auerbach, and Frank X. Donovan. Their collaborative efforts have resulted in multiple co-authored publications across various domains related to DNA repair and cancer biology.

Best Publications

  • ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

    Shuhei Matsuoka;Bryan A. Ballif;Agata Smogorzewska;Agata Smogorzewska;E. Robert McDonald

  • TRF2 Protects Human Telomeres from End-to-End Fusions

    Bas van Steensel;Agata Smogorzewska;Titia de Lange

  • DNA Damage Foci at Dysfunctional Telomeres

    Hiroyuki Takai;Agata Smogorzewska;Titia de Lange

  • Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2.

    Broccoli D;Smogorzewska A;Chong L;de Lange T

  • Control of human telomere length by TRF1 and TRF2.

    Agata Smogorzewska;Bas van Steensel;Alessandro Bianchi;Stefan Oelmann

  • Regulation of Telomerase by Telomeric Proteins

    Agata Smogorzewska;Titia de Lange

  • Senescence Induced by Altered Telomere State, Not Telomere Loss

    Jan Karlseder;Agata Smogorzewska;Titia de Lange

  • Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair.

    Agata Smogorzewska;Agata Smogorzewska;Shuhei Matsuoka;Patrizia Vinciguerra;E. Robert McDonald

  • Abraxas and RAP80 Form a BRCA1 Protein Complex Required for the DNA Damage Response

    Bin Wang;Shuhei Matsuoka;Bryan A. Ballif;Bryan A. Ballif;Dong Zhang

  • Homologous recombination generates T-loop-sized deletions at human telomeres.

    Richard C. Wang;Agata Smogorzewska;Titia de Lange

  • Fanconi anaemia and the repair of Watson and Crick DNA crosslinks

    Molly C. Kottemann;Agata Smogorzewska

  • Different telomere damage signaling pathways in human and mouse cells

    Agata Smogorzewska;Titia de Lange

  • The Fanconi Anemia Pathway Promotes Replication-Dependent DNA Interstrand Cross-Link Repair

    Puck Knipscheer;Markus Räschle;Agata Smogorzewska;Agata Smogorzewska;Milica Enoiu

  • Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair

    Jennifer M. Svendsen;Agata Smogorzewska;Agata Smogorzewska;Mathew E. Sowa;Brenda C. O'Connell

  • DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2.

    Agata Smogorzewska;Jan Karlseder;Heidi Holtgreve-Grez;Anna Jauch

  • Cancer Proliferation Gene Discovery Through Functional Genomics

    Michael R. Schlabach;Ji Luo;Nicole L. Solimini;Guang Hu

  • A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response

    Britt Adamson;Agata Smogorzewska;Agata Smogorzewska;Frederic D. Sigoillot;Randall W. King

  • Exome Capture Reveals ZNF423 and CEP164 Mutations, Linking Renal Ciliopathies to DNA Damage Response Signaling

    Moumita Chaki;Rannar Airik;Amiya K. Ghosh;Rachel H. Giles

  • Mutations of the SLX4 gene in Fanconi anemia

    Yonghwan Kim;Francis P Lach;Rohini Desetty;Helmut Hanenberg;Helmut Hanenberg

  • A Genetic Screen Identifies FAN1, a Fanconi Anemia-Associated Nuclease Necessary for DNA Interstrand Crosslink Repair

    Agata Smogorzewska;Agata Smogorzewska;Agata Smogorzewska;Rohini Desetty;Takamune T. Saito;Michael Schlabach

Frequent Co-Authors

Stephen J. Elledge
Stephen J. Elledge Harvard University
Arleen D. Auerbach
Arleen D. Auerbach Rockefeller University
Settara C. Chandrasekharappa
Settara C. Chandrasekharappa National Institutes of Health
Titia de Lange
Titia de Lange Rockefeller University
Friedhelm Hildebrandt
Friedhelm Hildebrandt Boston Children's Hospital
Steven P. Gygi
Steven P. Gygi Harvard University
Bryan A. Ballif
Bryan A. Ballif University of Vermont
Kenneth Offit
Kenneth Offit Memorial Sloan Kettering Cancer Center
Elaine A. Ostrander
Elaine A. Ostrander National Institutes of Health
Olivier Elemento
Olivier Elemento Cornell University

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