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Settara C. Chandrasekharappa

Settara C. Chandrasekharappa

D-Index & Metrics

Genetics

D-Index
67
Citations
30256
World Ranking
2489
National Ranking
1116

Overview

Settara C. Chandrasekharappa is affiliated with the National Institutes of Health in the United States. Their research primarily focuses on the fields of biochemistry, genetics, and molecular biology, with a significant number of publications in medicine. Within these domains, they have contributed notably to molecular biology, genetics, hematology, oncology, and cancer research.

The scientist's main research topics encompass DNA repair mechanisms, CRISPR and genetic engineering, cancer-related molecular pathways, prenatal screening and diagnostics, carcinogens and genotoxicity assessment, epigenetics and DNA methylation, as well as genetic factors in colorectal cancer.

Chandrasekharappa has contributed to numerous peer-reviewed publications, with frequent appearances in several respected venues. These include bioRxiv (Cold Spring Harbor Laboratory), Blood, Proceedings of the National Academy of Sciences, Blood Advances, and Molecular Case Studies.

Among their recent papers are:

  • Common genetic susceptibility loci link PFAPA syndrome, Behçet's disease, and recurrent aphthous stomatitis, 2020, Proceedings of the National Academy of Sciences
  • Genomic signature of Fanconi anaemia DNA repair pathway deficiency in cancer, 2022, Nature
  • Association of clinical severity with FANCB variant type in Fanconi anemia, 2020, Blood
  • Comparative clinical and genomic analysis of neurofibromatosis type 2-associated cranial and spinal meningiomas, 2020, Scientific Reports
  • Genomic landscape of patients with germline RUNX1 variants and familial platelet disorder with myeloid malignancy, 2023, Blood Advances

Chandrasekharappa has collaborated frequently with several co-authors including Frank X. Donovan, Agata Smogorzewska, Francis P. Lach, Arleen D. Auerbach, and Raymond J. Noonan.

Best Publications

  • Mutation in the α-synuclein gene identified in families with Parkinson's disease

    Mihael H. Polymeropoulos;Christian Lavedan;Elisabeth Leroy;Susan E. Ide

  • Positional Cloning of the Gene for Multiple Endocrine Neoplasia-Type 1

    Settara C. Chandrasekharappa;Siradanahalli C. Guru;Pachiappan Manickam;Shodimu Emmanuel Olufemi

  • Mutations in the human Jagged1 gene are responsible for Alagille syndrome

    Takaya Oda;Abdel G. Elkahloun;Brian L. Pike;Kazuki Okajima

  • Mind Bomb Is a Ubiquitin Ligase that Is Essential for Efficient Activation of Notch Signaling by Delta

    Motoyuki Itoh;Cheol-Hee Kim;Gregory Palardy;Takaya Oda

  • Menin Interacts with the AP1 Transcription Factor JunD and Represses JunD-Activated Transcription

    Sunita K. Agarwal;Siradanahalli C. Guru;Christina Heppner;Michael R. Erdos

  • Isolation of a partial candidate gene for Menkes disease by positional cloning.

    Julian F. B. Mercer;Janie Livingston;Bryan Hall;Jennifer A. Paynter

  • Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease

    Qing Zhou;Hongying Wang;Daniella M. Schwartz;Monique Stoffels

  • Menin, the product of the MEN1 gene, is a nuclear protein

    Siradanahalli C. Guru;Paul K. Goldsmith;A. Lee Burns;Stephen J. Marx

  • Germline Mutations of the MEN1 Gene in Familial Multiple Endocrine Neoplasia Type 1 and Related States

    Sunita K. Agarwal;Mary Beth Kester;Larisa V. Debelenko;Christina Heppner

  • A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors

    Judy S. Crabtree;Peter Christopher Scacheri;Jerrold M. Ward;Lisa Garrett-Beal

  • Repressor activity of Headless/Tcf3 is essential for vertebrate head formation.

    Cheol-Hee Kim;Takaya Oda;Motoyuki Itoh;Di Jiang

  • Somatic mutation of the MEN1 gene in parathyroid tumours.

    Heppner C;Kester Mb;Agarwal Sk;Debelenko Lv

  • Identification of the gene (BBS1) most commonly involved in Bardet-Biedl syndrome, a complex human obesity syndrome.

    Kirk Mykytyn;Darryl Y. Nishimura;Charles C. Searby;Mythreyi Shastri

  • A Novel Putative Low-Affinity Insulin-like Growth Factor-binding Protein, LIBC (Lost in Inflammatory Breast Cancer), and RhoC GTPase Correlate with the Inflammatory Breast Cancer Phenotype

    Kenneth L. Van Golen;Seena Davies;Zhi Fen Wu;Yun Fang Wang

  • Somatic mutations of the MEN1 tumor suppressor gene in sporadic gastrinomas and insulinomas

    Zhengping Zhuang;Alexander O. Vortmeyer;Svetlana Pack;Steve Huang

  • The tumor suppressor protein menin interacts with NF-κb proteins and inhibits NF-κb-mediated transactivation

    Christina Heppner;Karl Y. Bilimoria;Sunita K. Agarwal;Mary Beth Kester

  • Low incidence of DNA sequence variation in human induced pluripotent stem cells generated by nonintegrating plasmid expression.

    Linzhao Cheng;Nancy F. Hansen;Ling Zhao;Yutao Du

  • Mutations of the MEN1 Tumor Suppressor Gene in Pituitary Tumors

    Zhengping Zhuang;Shereen Z. Ezzat;Alexander O. Vortmeyer;Robert Weil

  • Identification of MEN1 Gene Mutations in Sporadic Carcinoid Tumors of the Lung

    Larisa V. Debelenko;Elisabeth Brambilla;Sunita K. Agarwal;Jennifer I. Swalwell

  • Of Mice and MEN1: Insulinomas in a Conditional Mouse Knockout

    Judy S. Crabtree;Peter C. Scacheri;Jerrold M. Ward;Sara R. McNally

Frequent Co-Authors

Francis S. Collins
Francis S. Collins National Institutes of Health
Stephen J. Marx
Stephen J. Marx National Institutes of Health
Allen M. Spiegel
Allen M. Spiegel Albert Einstein College of Medicine
Michael R. Emmert-Buck
Michael R. Emmert-Buck Avoneaux Medical Institute
Lance A. Liotta
Lance A. Liotta George Mason University
Abdel G. Elkahloun
Abdel G. Elkahloun National Human Genome Research Institute
James C. Mullikin
James C. Mullikin National Institutes of Health
Zhengping Zhuang
Zhengping Zhuang National Institutes of Health
Arleen D. Auerbach
Arleen D. Auerbach Rockefeller University
Agata Smogorzewska
Agata Smogorzewska Rockefeller University

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