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Molecular Biology

D-Index
71
Citations
33128
World Ranking
1343
National Ranking
38

Research.com Recognitions

  • 2016 - Member of Academia Europaea
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Reuven Agami is affiliated with the Antoni van Leeuwenhoek Hospital in the Netherlands. Their research spans biochemistry, genetics, molecular biology, and medicine, with a focus on molecular biology, oncology, immunology, biological psychiatry, and cancer research. This multi-disciplinary approach emphasizes the intersections of RNA biology, cancer, and immune responses.

The scientist's recent papers cover a range of topics including tumor immunology, RNA dynamics, and cancer biology. Notable publications include:

  • Anti-tumour immunity induces aberrant peptide presentation in melanoma (2020, Nature)
  • Tryptophan depletion results in tryptophan-to-phenylalanine substitutants (2022, Nature)
  • Transcription Dynamics Regulate Poly(A) Tails and Expression of the RNA Degradation Machinery to Balance mRNA Levels (2020, Molecular Cell)
  • DNA damage induces p53-independent apoptosis through ribosome stalling (2024, Science)
  • Proteomic patterns associated with response to breast cancer neoadjuvant treatment (2020, Molecular Systems Biology)

Agami has frequently published in venues such as Molecular Cell, Nature, bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, and Oncogene. This distribution indicates active involvement in both established journals and preprint platforms relevant to molecular biology and cancer research.

The scientist's main research topics include:

  • RNA modifications and cancer
  • RNA and protein synthesis mechanisms
  • RNA research and splicing
  • Peptidase inhibition and analysis
  • Immunotherapy and immune responses
  • Vaccines and immunoinformatics approaches
  • Tryptophan and brain disorders

Frequent collaborators in their work are Julien Champagne, Abhijeet Pataskar, Onno B. Bleijerveld, Pierre-René Körner, and Remco Nagel, reflecting a collaborative research environment with recurring partnerships.

Agami's contributions have been recognized through memberships in prominent scientific organizations, including the Academia Europaea since 2016 and the European Molecular Biology Organization (EMBO).

Best Publications

  • A System for Stable Expression of Short Interfering RNAs in Mammalian Cells

    Thijn R. Brummelkamp;René Bernards;Reuven Agami

  • Stable suppression of tumorigenicity by virus-mediated RNA interference.

    Thijn R Brummelkamp;René Bernards;Reuven Agami

  • A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors.

    P Mathijs Voorhoeve;Carlos le Sage;Mariette Schrier;Ad J M Gillis

  • A large-scale RNAi screen in human cells identifies new components of the p53 pathway

    Katrien Berns;E. Marielle Hijmans;Jasper Mullenders;Thijn R. Brummelkamp

  • The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis

    Huang Q;Gumireddy K;Schrier M;le Sage C

  • Regulation of the p27Kip1 tumor suppressor by miR‐221 and miR‐222 promotes cancer cell proliferation

    Carlos le Sage;Remco Nagel;David A Egan;Mariette Schrier

  • RNA-binding protein Dnd1 inhibits microRNA access to target mRNA.

    Martijn Kedde;Markus J. Strasser;Bijan Boldajipour;Joachim A.F. Oude Vrielink

  • Alternative cleavage and polyadenylation: extent, regulation and function

    Ran Elkon;Alejandro P. Ugalde;Reuven Agami

  • Interaction of c-Abl and p73α and their collaboration to induce apoptosis

    Reuven Agami;Giovanni Blandino;Moshe Oren;Yosef Shaul

  • miR-148 targets human DNMT3b protein coding region.

    Anja M. Duursma;Martijn Kedde;Mariette Schrier;Carlos le Sage

  • MicroRNA regulation by RNA-binding proteins and its implications for cancer

    Marieke van Kouwenhove;Martijn Kedde;Reuven Agami;Reuven Agami

  • Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector.

    Marc van de Wetering;Irma Oving;Vanesa Muncan;Menno Tjon Pon Fong

  • The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo

    Jason T. Huse;Cameron Brennan;Dolores Hambardzumyan;Boyoung Wee

  • Regulation of the Adenomatous Polyposis Coli Gene by the miR-135 Family in Colorectal Cancer

    Remco Nagel;Carlos le Sage;Begoña Diosdado;Maike van der Waal

  • eRNAs are required for p53-dependent enhancer activity and gene transcription

    Carlos A. Melo;Carlos A. Melo;Jarno Drost;Patrick J. Wijchers;Harmen van de Werken

  • Deregulation of microRNA-503 Contributes to Diabetes Mellitus–Induced Impairment of Endothelial Function and Reparative Angiogenesis After Limb Ischemia

    Andrea Caporali;Marco Meloni;Christine Vollenkle;Desireee Bonci

  • A Pumilio-induced RNA structure switch in p27-3′ UTR controls miR-221 and miR-222 accessibility

    Martijn Kedde;Marieke van Kouwenhove;Wilbert Zwart;Joachim A F Oude Vrielink

  • Distinct initiation and maintenance mechanisms cooperate to induce G1 cell cycle arrest in response to DNA damage.

    Reuven Agami;René Bernards

  • Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9

    Gozde Korkmaz;Rui Lopes;Alejandro P Ugalde;Ekaterina Nevedomskaya

  • Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension

    Susanne M.A. Lens;Rob M.F. Wolthuis;Rob Klompmaker;Jos Kauw

Frequent Co-Authors

Ran Elkon
Ran Elkon Tel Aviv University
René Bernards
René Bernards Antoni van Leeuwenhoek Hospital
Thijn R. Brummelkamp
Thijn R. Brummelkamp Antoni van Leeuwenhoek Hospital
Peter J.F. Snijders
Peter J.F. Snijders Vrije Universiteit Amsterdam
Giannino Del Sal
Giannino Del Sal University of Trieste
Yosef Shaul
Yosef Shaul Weizmann Institute of Science
Renske D.M. Steenbergen
Renske D.M. Steenbergen University of Amsterdam
Chris J.L.M. Meijer
Chris J.L.M. Meijer Vrije Universiteit Amsterdam
Elzo de Wit
Elzo de Wit Antoni van Leeuwenhoek Hospital
Manel Esteller
Manel Esteller Josep Carreras Leukaemia Research Institute

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