World's Best Scientists 2026 revealed!
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Biology and Biochemistry
Netherlands
2023

D-Index & Metrics

Genetics

D-Index
117
Citations
89793
World Ranking
418
National Ranking
14

Medicine

D-Index
120
Citations
95189
World Ranking
3652
National Ranking
141

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Netherlands Leader Award
  • 2020 - Member of the National Academy of Sciences
  • 2019 - Fellow of the American Academy of Arts and Sciences
  • 2007 - Royal Netherlands Academy of Arts and Sciences
  • 2005 - Member of Academia Europaea
  • 2005 - Spinoza Prize, Dutch Research Council
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

René Bernards is affiliated with the Antoni van Leeuwenhoek Hospital in the Netherlands, focusing primarily on biochemistry, genetics, and molecular biology. Their work spans 153 publications in these fields, with a significant emphasis on medicine, represented by 115 publications.

The research contributions are concentrated in several subfields, including molecular biology, oncology, pulmonary and respiratory medicine, cancer research, and physiology. This multidisciplinary approach supports investigations into complex biological processes and disease mechanisms.

The main topics covered by their research include:

  • Telomeres, Telomerase, and Senescence
  • Ubiquitin and proteasome pathways
  • Cancer Genomics and Diagnostics
  • Colorectal Cancer Treatments and Studies
  • CRISPR and Genetic Engineering
  • Protein Degradation and Inhibitors
  • PI3K/AKT/mTOR signaling in cancer

René Bernards has contributed to numerous recent scientific papers, such as:

  • Exploiting senescence for the treatment of cancer, 2022, Nature Reviews Cancer
  • Evolving therapeutic landscape of advanced hepatocellular carcinoma, 2022, Nature Reviews Gastroenterology & Hepatology
  • EGFR activation limits the response of liver cancer to lenvatinib, 2021, Nature
  • Rational combinations of targeted cancer therapies: background, advances and challenges, 2022, Nature Reviews Drug Discovery
  • Embracing cancer complexity: Hallmarks of systemic disease, 2024, Cell

Frequent collaborators in their research include Roderick L. Beijersbergen, Cor Lieftink, Wenxin Qin, Liqin Wang, and Fleur Jochems. Their work also appears regularly in several scientific venues, with multiple publications in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Molecular Oncology
  • Cancer Research
  • Proceedings of the National Academy of Sciences
  • Nature Cancer

Throughout their career, René Bernards has received recognition through a variety of awards and memberships, including:

  • Member of the National Academy of Sciences, 2020
  • Fellow of the American Academy of Arts and Sciences, 2019
  • Royal Netherlands Academy of Arts and Sciences, 2007
  • Member of Academia Europaea, 2005
  • Spinoza Prize, Dutch Research Council, 2005
  • Member of the European Molecular Biology Organization (EMBO)

Best Publications

  • Gene expression profiling predicts clinical outcome of breast cancer

    Laura J. van 't Veer;Hongyue Dai;Marc J. van de Vijver;Yudong D. He

  • A Gene-Expression Signature as a Predictor of Survival in Breast Cancer

    Marc J. van de Vijver;Yudong D. He;Laura J. van 't Veer;Hongyue Dai

  • A System for Stable Expression of Short Interfering RNAs in Mammalian Cells

    Thijn R. Brummelkamp;René Bernards;Reuven Agami

  • The consensus molecular subtypes of colorectal cancer

    Justin Guinney;Rodrigo Dienstmann;Rodrigo Dienstmann;Xingwu Wang;Xingwu Wang;Aurélien De Reyniès

  • A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

    Stephen H. Friend;Stephen H. Friend;Rene Bernards;Snezna Rogelj;Robert A. Weinberg

  • Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR

    Anirudh Prahallad;Chong Sun;Sidong Huang;Federica Di Nicolantonio

  • A Genomic and Functional Inventory of Deubiquitinating Enzymes

    Sebastian M.B. Nijman;Mark P.A. Luna-Vargas;Arno Velds;Thijn R. Brummelkamp

  • A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer.

    Katrien Berns;Hugo M. Horlings;Bryan T. Hennessy;Mandy Madiredjo

  • 70-Gene Signature as an Aid to Treatment Decisions in Early-Stage Breast Cancer

    Fatima Cardoso;Laura J. van’t Veer;Jan Bogaerts;Leen Slaets

  • Stable suppression of tumorigenicity by virus-mediated RNA interference.

    Thijn R Brummelkamp;René Bernards;Reuven Agami

  • A large-scale RNAi screen in human cells identifies new components of the p53 pathway

    Katrien Berns;E. Marielle Hijmans;Jasper Mullenders;Thijn R. Brummelkamp

  • Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB

    Thijn R. Brummelkamp;Sebastian M. B. Nijman;Annette M. G. Dirac;René Bernards

  • An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer.

    Katherine Stemke-Hale;Ana Maria Gonzalez-Angulo;Ana Lluch;Richard M. Neve

  • A progression puzzle.

    René Bernards;Robert A. Weinberg

  • Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma

    Chong Sun;Liqin Wang;Sidong Huang;Guus J. J. E. Heynen

  • CDK-Independent Activation of Estrogen Receptor by Cyclin D1

    Renate M.L Zwijsen;Ellen Wientjens;Rob Klompmaker;Jeroen van der Sman

  • The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene

    Benjamin D. Rowland;René Bernards;Daniel S. Peeper

  • Enabling personalized cancer medicine through analysis of gene-expression patterns

    Laura J. van 't Veer;René Bernards

  • The Deubiquitinating Enzyme USP1 Regulates the Fanconi Anemia Pathway

    Sebastian M.B. Nijman;Tony T. Huang;Annette M.G. Dirac;Thijn R. Brummelkamp

  • Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence

    Roderik M. Kortlever;Paul J. Higgins;René Bernards

Frequent Co-Authors

Roderick L. Beijersbergen
Roderick L. Beijersbergen Antoni van Leeuwenhoek Hospital
Lodewyk F. A. Wessels
Lodewyk F. A. Wessels Antoni van Leeuwenhoek Hospital
Carlos Caldas
Carlos Caldas University of Cambridge
Laura J. van't Veer
Laura J. van't Veer University of California, San Francisco
Thijn R. Brummelkamp
Thijn R. Brummelkamp Antoni van Leeuwenhoek Hospital
Suet-Feung Chin
Suet-Feung Chin University of Cambridge
Stephen H. Friend
Stephen H. Friend Sage Bionetworks
A. J. Van Der Eb
A. J. Van Der Eb Leiden University
Mauro Delorenzi
Mauro Delorenzi University of Lausanne
Marc J. van de Vijver
Marc J. van de Vijver University of Amsterdam

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