World's Best Scientists 2026 revealed!
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Genetics
USA
2026

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Best Scientists

D-Index
164
Citations
111858
World Ranking
1081
National Ranking
644

Genetics

D-Index
164
Citations
111274
World Ranking
85
National Ranking
42

Medicine

D-Index
165
Citations
115088
World Ranking
629
National Ranking
359

Research.com Recognitions

  • 2026 - Research.com Genetics in United States Leader Award
  • 2025 - Research.com Genetics in United States Leader Award
  • 2024 - Research.com Genetics in United States Leader Award
  • 2023 - Research.com Genetics in United States Leader Award
  • 2019 - Fellow of the American Academy of Arts and Sciences
  • 2008 - Fellow of the Royal Society, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Alan Ashworth is affiliated with the University of California, San Francisco in the United States. Their research spans primarily within Biochemistry, Genetics and Molecular Biology as well as Medicine. They have contributed significantly to subfields including Genetics, Oncology, Molecular Biology, Immunology, and Physiology.

Their main research topics cover a range of areas such as Genetic Associations and Epidemiology, BRCA gene mutations in cancer, Estrogen and related hormone effects, PARP inhibition in cancer therapy, Toxin Mechanisms and Immunotoxins, Calcium signaling and nucleotide metabolism, and Bioinformatics and Genomic Networks.

Among recent publications, their notable papers include:

  • A network analysis to identify mediators of germline-driven differences in breast cancer prognosis, 2020, Nature Communications
  • Common Susceptibility Loci for Male Breast Cancer, 2020, JNCI Journal of the National Cancer Institute
  • Correction to: Timing of pubertal stages and breast cancer risk: the Breakthrough Generations Study, 2020, Breast Cancer Research
  • Discovery of a Novel [6-6-5-5-6] Pentacyclic Tetrahydrocyclopentaphthalazinone as a Promising PARP Inhibitor Scaffold, 2025, ACS Medicinal Chemistry Letters
  • Correction: A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D, 2020, Oncogene

Their work has appeared frequently in leading venues such as Cancer Research, Nature Communications, JNCI Journal of the National Cancer Institute, Breast Cancer Research, and ACS Medicinal Chemistry Letters.

Alan Ashworth has collaborated often with coauthors including Morgan E. Diolaiti, Michael E. Jones, Stig E. Bojesen, Alison M. Dunning, and Henrik Flyger.

Throughout their career, they have received several recognitions including being named a Fellow of the Royal Society, United Kingdom in 2008, a Fellow of the American Academy of Arts and Sciences in 2019, membership in the European Molecular Biology Organization (EMBO), and Fellowship of The Academy of Medical Sciences, United Kingdom.

Best Publications

  • Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

    Hannah Farmer;Nuala McCabe;Christopher J. Lord;Andrew N. J. Tutt;Andrew N. J. Tutt

  • A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.

    David E. Gordon;Gwendolyn M. Jang;Mehdi Bouhaddou;Jiewei Xu

  • Identification of the breast cancer susceptibility gene BRCA2

    Wooster R;Bignell G;Lancaster J;Swift S

  • Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from BRCA Mutation Carriers

    Peter C Fong;David S Boss;Timothy A Yap;Andrew Tutt

  • DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer.

    Joaquin Mateo;Suzanne Carreira;Shahneen Sandhu;Susana Miranda

  • PARP inhibitors: Synthetic lethality in the clinic

    Christopher J. Lord;Alan Ashworth

  • Hallmarks of 'BRCAness' in sporadic cancers

    Nicholas Turner;Andrew Tutt;Alan Ashworth

  • The DNA damage response and cancer therapy

    Christopher J. Lord;Alan Ashworth

  • Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition.

    Nuala McCabe;Nicholas C. Turner;Christopher J. Lord;Katarzyna Kluzek

  • The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus.

    Neil Brockdorff;Alan Ashworth;Graham F. Kay;Veronica M. McCabe

  • Large-scale genotyping identifies 41 new loci associated with breast cancer risk

    Kyriaki Michailidou;Per Hall;Anna Gonzalez-Neira;Maya Ghoussaini

  • CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members.

    Eirini Trompouki;Eudoxia Hatzivassiliou;Theodore Tsichritzis;Hannah Farmer

  • A Synthetic Lethal Therapeutic Approach: Poly(ADP) Ribose Polymerase Inhibitors for the Treatment of Cancers Deficient in DNA Double-Strand Break Repair

    Alan Ashworth

  • Poly(ADP)-Ribose Polymerase Inhibition: Frequent Durable Responses in BRCA Carrier Ovarian Cancer Correlating With Platinum-Free Interval

    Peter C. Fong;Timothy A. Yap;David S. Boss;Craig P. Carden

  • Resistance to therapy caused by intragenic deletion in BRCA2

    Stacey L. Edwards;Rachel Brough;Christopher J. Lord;Rachael Natrajan

  • 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase.

    Dario R. Alessi;Maria Deak;Antonio Casamayor;F. Barry Caudwell

  • BRCA1 Basal-like Breast Cancers Originate from Luminal Epithelial Progenitors and Not from Basal Stem Cells

    Gemma Molyneux;Felipe C. Geyer;Fiona-Ann Magnay;Afshan McCarthy

  • Identification of the familial cylindromatosis tumour-suppressor gene.

    Graham R. Bignell;William Warren;Sheila Seal;Meiko Takahashi

  • The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability.

    K Gudmundsdottir;A Ashworth

  • Erratum: Identification of the breast cancer susceptibility gene BRCA2

    Richard Wooster;Graham Bignell;Jonathan Lancaster;Sally Swift

Frequent Co-Authors

Christopher J. Lord
Christopher J. Lord Institute of Cancer Research
Jorge S. Reis-Filho
Jorge S. Reis-Filho Memorial Sloan Kettering Cancer Center
Anthony J. Swerdlow
Anthony J. Swerdlow Institute of Cancer Research
Alan Mackay
Alan Mackay Institute of Cancer Research
Nick Orr
Nick Orr Queen's University Belfast
Rachael Natrajan
Rachael Natrajan Institute of Cancer Research
Graham G. Giles
Graham G. Giles University of Melbourne
Hiltrud Brauch
Hiltrud Brauch German Cancer Research Center
Michael E. Jones
Michael E. Jones Macquarie University
Olivia Fletcher
Olivia Fletcher Institute of Cancer Research

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