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Genetics

D-Index
71
Citations
26199
World Ranking
2162
National Ranking
267

Overview

Nick Orr is affiliated with Queen's University Belfast in the United Kingdom. Their research spans multiple interconnected fields within biochemistry, genetics, molecular biology, and medicine. The scientist's work encompasses both broad and specialized areas, contributing primarily to genetics, molecular biology, oncology, public health, and computational theory.

The main topics covered in their research include:

  • BRCA gene mutations in cancer
  • Genetic Associations and Epidemiology
  • Estrogen and related hormone effects
  • Nutrition, Genetics, and Disease
  • Topological and Geometric Data Analysis
  • Bioinformatics and Genomic Networks
  • MicroRNA in disease regulation

The scientist has authored several research papers published in notable academic journals. Some of the recent publications include:

  • Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility, 2020, Nature Genetics
  • Combined Associations of a Polygenic Risk Score and Classical Risk Factors With Breast Cancer Risk, 2020, JNCI Journal of the National Cancer Institute
  • The topology of data: opportunities for cancer research, 2021, Bioinformatics
  • Assessment of structural chromosomal instability phenotypes as biomarkers of carboplatin response in triple negative breast cancer: the TNT trial, 2020, Annals of Oncology
  • Common Susceptibility Loci for Male Breast Cancer, 2020, JNCI Journal of the National Cancer Institute

Nick Orr frequently collaborates with other researchers, with several co-authors appearing regularly throughout their publications. These include:

  • Håkan Olsson
  • Sara Lindström
  • Kyriaki Michailidou
  • Manjeet K. Bolla
  • Jonine D. Figueroa

Their work is often disseminated through diverse publication venues, with repeated contributions to the following journals and platforms:

  • UNC Libraries
  • JNCI Journal of the National Cancer Institute
  • Research Square (Research Square)
  • Nature Genetics
  • Bioinformatics

Nick Orr's research integrates genetics and molecular biology methodologies to explore complex mechanisms underlying cancer susceptibility, particularly focusing on the genetic variants associated with breast cancer and melanoma. Their investigations into the interplay of polygenic risk scores with classical risk factors support broader epidemiological insights. Moreover, their interest in computational topology and bioinformatics provides innovative tools for cancer research and biomarker development.

Best Publications

  • A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer

    David J Hunter;David J Hunter;Peter Kraft;Kevin B Jacobs;David G Cox

  • Association analysis identifies 65 new breast cancer risk loci

    Kyriaki Michailidou;Kyriaki Michailidou;Sara Lindström;Sara Lindström;Joe Dennis;Jonathan Beesley

  • Genome-wide association study of prostate cancer identifies a second risk locus at 8q24

    Meredith Yeager;Nick Orr;Richard B Hayes;Kevin B Jacobs

  • Large-scale genotyping identifies 41 new loci associated with breast cancer risk

    Kyriaki Michailidou;Per Hall;Anna Gonzalez-Neira;Maya Ghoussaini

  • Multiple loci identified in a genome-wide association study of prostate cancer

    Gilles Thomas;Kevin B Jacobs;Meredith Yeager;Meredith Yeager;Peter Kraft

  • RAD51B in Familial Breast Cancer

    Liisa M. Pelttari;Sofia Khan;Mikko Vuorela;Johanna I. Kiiski

  • Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes

    Nasim Mavaddat;Kyriaki Michailidou;Kyriaki Michailidou;Joe Dennis;Michael Lush

  • Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer

    Kyriaki Michailidou;Jonathan Beesley;Sara Lindstrom;Sander Canisius

  • A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1).

    Gilles Thomas;Kevin B Jacobs;Kevin B Jacobs;Peter Kraft;Meredith Yeager;Meredith Yeager

  • Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

    Stig E. Bojesen;Stig E. Bojesen;Karen A. Pooley;Sharon E. Johnatty;Jonathan Beesley

  • Prediction of Breast Cancer Risk Based on Profiling With Common Genetic Variants

    Nasim Mavaddat;Paul D.P. Pharoah;Kyriaki Michailidou;Jonathan Tyrer

  • MicroRNA related polymorphisms and breast cancer risk

    Sofia Khan;Dario Greco;Dario Greco;Kyriaki Michailidou;Roger L. Milne;Roger L. Milne

  • A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration.

    Anne E Hughes;Nick Orr;Hossein Esfandiary;Martha Diaz-Torres

  • Genome-wide association studies identify four ER negative-specific breast cancer risk loci

    Montserrat Garcia-Closas;Fergus J. Couch;Sara Lindstrom;Kyriaki Michailidou

  • Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

    Catherine M Phelan;Karoline B Kuchenbaecker;Karoline B Kuchenbaecker;Jonathan P Tyrer;Siddhartha P Kar

  • TINF2, a Component of the Shelterin Telomere Protection Complex, Is Mutated in Dyskeratosis Congenita

    Sharon A. Savage;Neelam Giri;Gabriela M. Baerlocher;Nick Orr

  • Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer.

    Roger L Milne;Roger L Milne;Karoline B Kuchenbaecker;Karoline B Kuchenbaecker;Kyriaki Michailidou;Kyriaki Michailidou;Jonathan Beesley

  • Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses

    Haoyu Zhang;Haoyu Zhang;Thomas U. Ahearn;Julie Lecarpentier;Daniel Barnes

  • Genome-wide association analysis identifies three new breast cancer susceptibility loci

    Maya Ghoussaini;Olivia Fletcher;Kyriaki Michailidou;Clare Turnbull

  • Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study.

    Olivia Fletcher;Nichola Johnson;Nick Orr;Fay J. Hosking

Frequent Co-Authors

Graham G. Giles
Graham G. Giles University of Melbourne
Hiltrud Brauch
Hiltrud Brauch German Cancer Research Center
Anthony J. Swerdlow
Anthony J. Swerdlow Institute of Cancer Research
Roger L. Milne
Roger L. Milne Cancer Council Victoria
Jenny Chang-Claude
Jenny Chang-Claude German Cancer Research Center
Douglas F. Easton
Douglas F. Easton University of Cambridge
Montserrat Garcia-Closas
Montserrat Garcia-Closas National Institutes of Health
Melissa C. Southey
Melissa C. Southey Monash University
Barbara Burwinkel
Barbara Burwinkel Heidelberg University
Irene L. Andrulis
Irene L. Andrulis University of Toronto

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