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D-Index & Metrics

Biology and Biochemistry

D-Index
81
Citations
22882
World Ranking
3909
National Ranking
289

Overview

Alan Mackay is affiliated with the Institute of Cancer Research in the United Kingdom, contributing extensively to research in medicine and biochemistry, genetics, and molecular biology. Their work predominantly focuses on genetics, molecular biology, and cancer research, with additional involvement in neurology and oncology.

The scientist's primary research topics include glioma diagnosis and treatment, epigenetics and DNA methylation, cancer genomics and diagnostics, cancer-related molecular mechanisms, neuroblastoma research and treatments, RNA modifications and cancer, and single-cell and spatial transcriptomics.

Alan Mackay has published numerous papers in notable venues, with frequent contributions to journals such as Neuro-Oncology, bioRxiv (Cold Spring Harbor Laboratory), Cancer Discovery, Acta Neuropathologica, and Clinical Cancer Research.

Some of the recent publications are:

  • Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes, 2020, Cancer Discovery
  • Pediatric pan-central nervous system tumor analysis of immune-cell infiltration identifies correlates of antitumor immunity, 2020, Nature Communications
  • Histone H3 wild-type DIPG/DMG overexpressing EZHIP extend the spectrum diffuse midline gliomas with PRC2 inhibition beyond H3-K27M mutation, 2020, Acta Neuropathologica
  • Droplet digital PCR-based detection of circulating tumor DNA from pediatric high grade and diffuse midline glioma patients, 2021, Neuro-Oncology Advances
  • Platelet-derived growth factor beta is a potent inflammatory driver in paediatric high-grade glioma, 2020, Brain

Alan Mackay frequently collaborates with a group of researchers, including Chris Jones, Yura Grabovska, Sara Temelso, Maria Vinci, and Valeria Molinari. These collaborations underline a network of co-authors contributing jointly to the research outputs.

Best Publications

  • New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs

    Dominik Sturm;Dominik Sturm;Brent A. Orr;Umut H. Toprak;Volker Hovestadt

  • Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma

    Alan Mackay;Anna Burford;Diana Carvalho;Elisa Izquierdo

  • BRCA1 Basal-like Breast Cancers Originate from Luminal Epithelial Progenitors and Not from Basal Stem Cells

    Gemma Molyneux;Felipe C. Geyer;Fiona-Ann Magnay;Afshan McCarthy

  • FGFR1 Amplification Drives Endocrine Therapy Resistance and Is a Therapeutic Target in Breast Cancer

    Nicholas Turner;Alex Pearson;Rachel Sharpe;Maryou Lambros

  • Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations

    Pawel Buczkowicz;Christine Hoeman;Patricia Rakopoulos;Sanja Pajovic

  • Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes.

    David Castel;Cathy Philippe;Raphaël Calmon;Ludivine Le Dret

  • Interleukin-18 (interferon-gamma-inducing factor) is produced by osteoblasts and acts via granulocyte/macrophage colony-stimulating factor and not via interferon-gamma to inhibit osteoclast formation.

    N Udagawa;N J Horwood;J Elliott;A Mackay

  • Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma

    Kathryn R Taylor;Alan Mackay;Nathalène Truffaux;Yaron S Butterfield

  • Breast cancer molecular profiling with single sample predictors: a retrospective analysis

    Britta Weigelt;Alan Mackay;Roger A'hern;Rachael Natrajan

  • Integrative molecular profiling of triple negative breast cancers identifies amplicon drivers and potential therapeutic targets.

    N Turner;M B Lambros;H M Horlings;A Pearson

  • β-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation.

    Felipe C Geyer;Magali Lacroix-Triki;Kay Savage;Monica Arnedos

  • PTEN Deficiency in Endometrioid Endometrial Adenocarcinomas Predicts Sensitivity to PARP Inhibitors

    Konstantin J. Dedes;Daniel Wetterskog;Ana M. Mendes-Pereira;Rachael Natrajan

  • FGFR1 Emerges as a Potential Therapeutic Target for Lobular Breast Carcinomas

    Jorge Sergio Reis-Filho;Pete T. Simpson;Nicholas C. Turner;Maryou Ballo Lambros

  • Histone H3.3 Mutations Drive Pediatric Glioblastoma through Upregulation of MYCN

    Lynn Bjerke;Alan Mackay;Meera Nandhabalan;Anna Burford

  • Expression Profiling of Purified Normal Human Luminal and Myoepithelial Breast Cells: Identification of Novel Prognostic Markers for Breast Cancer

    Chris Jones;Alan Mackay;Anita Grigoriadis;Antonio Cossu

  • EGFR amplification and lack of activating mutations in metaplastic breast carcinomas

    Jorge S. Reis-Filho;C. Pinheiro;M. B.K. Lambros;F. Milanezi;F. Milanezi

  • Caveolin 1 Is Overexpressed and Amplified in a Subset of Basal-like and Metaplastic Breast Carcinomas: A Morphologic, Ultrastructural, Immunohistochemical, and In situ Hybridization Analysis

    Kay Savage;Maryou B.K. Lambros;David Robertson;Robin L. Jones

  • ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma

    Carl Koschmann;Anda-Alexandra Calinescu;Felipe J. Nunez;Alan Mackay

  • Pleomorphic lobular carcinoma of the breast: role of comprehensive molecular pathology in characterization of an entity

    Jorge S Reis-Filho;Jorge S Reis-Filho;Pete T Simpson;Pete T Simpson;Chris Jones;Dawn Steele

  • Molecular analysis reveals a genetic basis for the phenotypic diversity of metaplastic breast carcinomas.

    Felipe C Geyer;Britta Weigelt;Rachael Natrajan;Maryou B K Lambros

Frequent Co-Authors

Chris Jones
Chris Jones Institute of Cancer Research
Jorge S. Reis-Filho
Jorge S. Reis-Filho Memorial Sloan Kettering Cancer Center
Alan Ashworth
Alan Ashworth University of California, San Francisco
Rachael Natrajan
Rachael Natrajan Institute of Cancer Research
Christopher J. Lord
Christopher J. Lord Institute of Cancer Research
Mitch Dowsett
Mitch Dowsett Breast Cancer Research Foundation
Stefan M. Pfister
Stefan M. Pfister German Cancer Research Center
Michelle Monje
Michelle Monje Stanford University
Marketa Zvelebil
Marketa Zvelebil University of Basel
Fernando Schmitt
Fernando Schmitt University of Porto

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