His scientific interests lie mostly in Internal medicine, Oxidative stress, Endocrinology, Biochemistry and Cell biology. Many of his studies on Internal medicine involve topics that are commonly interrelated, such as Diabetes mellitus. His study focuses on the intersection of Oxidative stress and fields such as Protein degradation with connections in the field of Immunology and Lipid oxidation.
His Endocrinology study incorporates themes from Alzheimer's disease and Cognitive decline. Cell surface receptor, Proteolysis, Extracellular, Calcium in biology and Calcium metabolism is closely connected to Neurotoxicity in his research, which is encompassed under the umbrella topic of Biochemistry. His study in Cell biology is interdisciplinary in nature, drawing from both Lipofuscin, Caspase and Neuron.
Jeffrey N. Keller mainly investigates Internal medicine, Endocrinology, Oxidative stress, Cell biology and Biochemistry. His Internal medicine study frequently draws connections to adjacent fields such as Diabetes mellitus. His research in Endocrinology intersects with topics in Microglia and Amyloid precursor protein.
His Oxidative stress research integrates issues from Reactive oxygen species, Oxidative phosphorylation and Programmed cell death. His biological study focuses on Proteasome. He interconnects Neurotoxicity, Astrocyte and Neuroprotection in the investigation of issues within Biochemistry.
The scientist’s investigation covers issues in Cognition, Disease, Dementia, Internal medicine and Pharmacology. His Disease study integrates concerns from other disciplines, such as Psychological intervention, Ubiquitin, Clinical trial and Protein aggregation. His Dementia research is multidisciplinary, incorporating perspectives in PI3K/AKT/mTOR pathway, Psychiatry and Randomized controlled trial.
His studies in Internal medicine integrate themes in fields like Endocrinology and Oncology. The various areas that he examines in his Endocrinology study include HIV Protease Inhibitor, Neuroprotection and Antioxidant. His work investigates the relationship between Pharmacology and topics such as Amyloid that intersect with problems in Toxicity, Endothelial stem cell and Mediterranean diet.
Jeffrey N. Keller spends much of his time researching Pharmacology, Obesity, Neuroprotection, Internal medicine and Endocrinology. His Pharmacology study combines topics in areas such as Precuneus, PI3K/AKT/mTOR pathway, P70-S6 Kinase 1, Phosphorylation and Neuropathology. He combines subjects such as Intervention, Adipose tissue, Mediator and Energy metabolism with his study of Obesity.
His studies deal with areas such as Protein kinase B, Neuroinflammation, Knockout mouse and Rivastigmine, Donepezil as well as Neuroprotection. Jeffrey N. Keller applies his multidisciplinary studies on Internal medicine and LRP1 in his research. The Endocrinology study combines topics in areas such as Antioxidant and Cell biology.
This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.
Mitochondrial Manganese Superoxide Dismutase Prevents Neural Apoptosis and Reduces Ischemic Brain Injury: Suppression of Peroxynitrite Production, Lipid Peroxidation, and Mitochondrial Dysfunction
Jeffrey N. Keller;Mark S. Kindy;Fredrick W. Holtsberg;Daret K. St. Clair.
The Journal of Neuroscience (1998)
Impaired proteasome function in Alzheimer's disease.
Jeffrey N. Keller;Keith B. Hanni;William R. Markesbery.
Journal of Neurochemistry (2001)
Evidence of increased oxidative damage in subjects with mild cognitive impairment
J. N. Keller;F. A. Schmitt;S. W. Scheff;Q. Ding.
Impairment of Glucose and Glutamate Transport and Induction of Mitochondrial Oxidative Stress and Dysfunction in Synaptosomes by Amyloid β-Peptide: Role of the Lipid Peroxidation Product 4-Hydroxynonenal
Jeffrey N. Keller;Zheng Pang;James W. Geddes;James G. Begley.
Journal of Neurochemistry (2002)
The glial glutamate transporter, GLT-1, is oxidatively modified by 4-hydroxy-2-nonenal in the Alzheimer's disease brain: the role of Aβ1–42
Christopher M. Lauderback;Janna M. Hackett;Feng F. Huang;Jeffrey N. Keller.
Journal of Neurochemistry (2001)
Cognitive impairment following high fat diet consumption is associated with brain inflammation.
Paul J. Pistell;Christopher D. Morrison;Sunita Gupta;Alecia G. Knight.
Journal of Neuroimmunology (2010)
4-Hydroxynonenal, an aldehydic product of membrane lipid peroxidation, impairs glutamate transport and mitochondrial function in synaptosomes
J.N Keller;R.J Mark;A.J Bruce;E. Blanc.
Evidence for synaptic apoptosis
Mark P. Mattson;Jeffrey N. Keller;James G. Begley.
Experimental Neurology (1998)
Antiinflammatory effects of estrogen on microglial activation.
Annadora J. Bruce-Keller;Jonathan L. Keeling;Jeffrey N. Keller;Feng F. Huang.
Protein modification by the lipid peroxidation product 4-hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients.
Ward A. Pedersen;Weiming Fu;Jeffrey N. Keller;William R. Markesbery.
Annals of Neurology (1998)
If you think any of the details on this page are incorrect, let us know.
We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below: