What is he best known for?
The fields of study he is best known for:
- Gene
- Enzyme
- Internal medicine
His scientific interests lie mostly in Internal medicine, Oxidative stress, Endocrinology, Biochemistry and Cell biology.
Many of his studies on Internal medicine involve topics that are commonly interrelated, such as Diabetes mellitus.
His study focuses on the intersection of Oxidative stress and fields such as Protein degradation with connections in the field of Immunology and Lipid oxidation.
His Endocrinology study incorporates themes from Alzheimer's disease and Cognitive decline.
Cell surface receptor, Proteolysis, Extracellular, Calcium in biology and Calcium metabolism is closely connected to Neurotoxicity in his research, which is encompassed under the umbrella topic of Biochemistry.
His study in Cell biology is interdisciplinary in nature, drawing from both Lipofuscin, Caspase and Neuron.
His most cited work include:
- Mitochondrial Manganese Superoxide Dismutase Prevents Neural Apoptosis and Reduces Ischemic Brain Injury: Suppression of Peroxynitrite Production, Lipid Peroxidation, and Mitochondrial Dysfunction (806 citations)
- Impaired proteasome function in Alzheimer's disease. (668 citations)
- Evidence of increased oxidative damage in subjects with mild cognitive impairment (442 citations)
What are the main themes of his work throughout his whole career to date?
Jeffrey N. Keller mainly investigates Internal medicine, Endocrinology, Oxidative stress, Cell biology and Biochemistry.
His Internal medicine study frequently draws connections to adjacent fields such as Diabetes mellitus.
His research in Endocrinology intersects with topics in Microglia and Amyloid precursor protein.
His Oxidative stress research integrates issues from Reactive oxygen species, Oxidative phosphorylation and Programmed cell death.
His biological study focuses on Proteasome.
He interconnects Neurotoxicity, Astrocyte and Neuroprotection in the investigation of issues within Biochemistry.
He most often published in these fields:
- Internal medicine (33.79%)
- Endocrinology (31.05%)
- Oxidative stress (30.59%)
What were the highlights of his more recent work (between 2015-2021)?
- Cognition (8.68%)
- Disease (12.33%)
- Dementia (9.13%)
In recent papers he was focusing on the following fields of study:
The scientist’s investigation covers issues in Cognition, Disease, Dementia, Internal medicine and Pharmacology.
His Disease study integrates concerns from other disciplines, such as Psychological intervention, Ubiquitin, Clinical trial and Protein aggregation.
His Dementia research is multidisciplinary, incorporating perspectives in PI3K/AKT/mTOR pathway, Psychiatry and Randomized controlled trial.
His studies in Internal medicine integrate themes in fields like Endocrinology and Oncology.
The various areas that he examines in his Endocrinology study include HIV Protease Inhibitor, Neuroprotection and Antioxidant.
His work investigates the relationship between Pharmacology and topics such as Amyloid that intersect with problems in Toxicity, Endothelial stem cell and Mediterranean diet.
Between 2015 and 2021, his most popular works were:
- Role of P-glycoprotein in mediating rivastigmine effect on amyloid-β brain load and related pathology in Alzheimer's disease mouse model (34 citations)
- The Complex Interactions Between Obesity, Metabolism and the Brain. (28 citations)
- High-Throughput Screening for Identification of Blood-Brain Barrier Integrity Enhancers: A Drug Repurposing Opportunity to Rectify Vascular Amyloid Toxicity. (27 citations)
In his most recent research, the most cited papers focused on:
- Gene
- Enzyme
- Internal medicine
Jeffrey N. Keller spends much of his time researching Pharmacology, Obesity, Neuroprotection, Internal medicine and Endocrinology.
His Pharmacology study combines topics in areas such as Precuneus, PI3K/AKT/mTOR pathway, P70-S6 Kinase 1, Phosphorylation and Neuropathology.
He combines subjects such as Intervention, Adipose tissue, Mediator and Energy metabolism with his study of Obesity.
His studies deal with areas such as Protein kinase B, Neuroinflammation, Knockout mouse and Rivastigmine, Donepezil as well as Neuroprotection.
Jeffrey N. Keller applies his multidisciplinary studies on Internal medicine and LRP1 in his research.
The Endocrinology study combines topics in areas such as Antioxidant and Cell biology.
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