World's Best Scientists 2026 revealed!

D-Index & Metrics

Neuroscience

D-Index
89
Citations
25525
World Ranking
1164
National Ranking
598

Biology and Biochemistry

D-Index
88
Citations
24921
World Ranking
2735
National Ranking
1416

Overview

Jeffrey N. Keller is affiliated with the Pennington Biomedical Research Center in the United States and has contributed extensively to the field of Medicine, with a particular focus on Psychiatry and Mental Health, Cognitive Neuroscience, Physical Therapy, Sports Therapy and Rehabilitation, Physiology, and Public Health, Environmental and Occupational Health.

The scientist's work spans a range of topics including Dementia and Cognitive Impairment Research, Older Adults Driving Studies, Urban Transport and Accessibility, Functional Brain Connectivity Studies, Frailty in Older Adults, Chinese history and philosophy, and Traffic and Road Safety.

Frequent publication venues include Alzheimer's & Dementia, Chinese Literature and Thought Today, Archives of Clinical Neuropsychology, Alzheimer's & Dementia Translational Research & Clinical Interventions, and Applied Neuropsychology Adult.

Recent papers authored or co-authored by Jeffrey N. Keller encompass:

  • Driving Performance in Older Adults: Current Measures, Findings, and Implications for Roadway Safety, 2022, Innovation in Aging
  • Predictors of Heterogeneity in Cognitive Function: APOE-e4, Sex, Education, Depression, and Vascular Risk, 2020, Archives of Clinical Neuropsychology
  • Do menopausal status and APOE4 genotype alter the long-term effects of intensive lifestyle intervention on cognitive function in women with type 2 diabetes mellitus?, 2020, Neurobiology of Aging
  • Feasibility and validation of a web-based platform for the self-administered patient collection of demographics, health status, anxiety, depression, and cognition in community dwelling elderly, 2021, PLoS ONE
  • Evaluation of noise regression techniques in resting-state fMRI studies using data of 434 older adults, 2022, Frontiers in Neuroscience

Among frequent collaborators are Suzanne Schmitz, Robin C. Hilsabeck, Heather Foil, Ellen F. Binder, and Eric D. Vidoni, each contributing jointly to multiple publications.

Best Publications

  • Mitochondrial Manganese Superoxide Dismutase Prevents Neural Apoptosis and Reduces Ischemic Brain Injury: Suppression of Peroxynitrite Production, Lipid Peroxidation, and Mitochondrial Dysfunction

    Jeffrey N. Keller;Mark S. Kindy;Fredrick W. Holtsberg;Daret K. St. Clair

  • Impaired proteasome function in Alzheimer's disease.

    Jeffrey N. Keller;Keith B. Hanni;William R. Markesbery

  • Cognitive impairment following high fat diet consumption is associated with brain inflammation.

    Paul J. Pistell;Christopher D. Morrison;Sunita Gupta;Alecia G. Knight

  • Evidence of increased oxidative damage in subjects with mild cognitive impairment

    J. N. Keller;F. A. Schmitt;S. W. Scheff;Q. Ding

  • Impairment of Glucose and Glutamate Transport and Induction of Mitochondrial Oxidative Stress and Dysfunction in Synaptosomes by Amyloid β-Peptide: Role of the Lipid Peroxidation Product 4-Hydroxynonenal

    Jeffrey N. Keller;Zheng Pang;James W. Geddes;James G. Begley

  • The glial glutamate transporter, GLT-1, is oxidatively modified by 4-hydroxy-2-nonenal in the Alzheimer's disease brain: the role of Aβ1–42

    Christopher M. Lauderback;Janna M. Hackett;Feng F. Huang;Jeffrey N. Keller

  • 4-Hydroxynonenal, an aldehydic product of membrane lipid peroxidation, impairs glutamate transport and mitochondrial function in synaptosomes

    J.N Keller;R.J Mark;A.J Bruce;E. Blanc

  • Ribosome Dysfunction Is an Early Event in Alzheimer's Disease

    Qunxing Ding;William R. Markesbery;Qinghua Chen;Feng Li

  • Evidence for synaptic apoptosis

    Mark P. Mattson;Jeffrey N. Keller;James G. Begley

  • Antiinflammatory effects of estrogen on microglial activation.

    Annadora J. Bruce-Keller;Jonathan L. Keeling;Jeffrey N. Keller;Feng F. Huang

  • Oxidative stress, neurodegeneration, and the balance of protein degradation and protein synthesis.

    Kalavathi Dasuri;Le Zhang;Jeffrey N. Keller

  • Protein modification by the lipid peroxidation product 4-hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients.

    Ward A. Pedersen;Weiming Fu;Jeffrey N. Keller;William R. Markesbery

  • Decreased levels of proteasome activity and proteasome expression in aging spinal cord.

    J.N Keller;F.F Huang;W.R Markesbery

  • Saturated long-chain fatty acids activate inflammatory signaling in astrocytes

    Sunita Gupta;Alecia G. Knight;Shruti Gupta;Jeffrey N. Keller

  • The lipid peroxidation product, 4-hydroxy-2-trans-nonenal, alters the conformation of cortical synaptosomal membrane proteins.

    R Subramaniam;F Roediger;B Jordan;M P Mattson

  • Possible involvement of proteasome inhibition in aging: implications for oxidative stress.

    Jeffrey N Keller;Keith B Hanni;William R Markesbery

  • The proteasome in brain aging.

    Jeffrey N Keller;Jillian Gee;Qunxing Ding

  • Autophagy, proteasomes, lipofuscin, and oxidative stress in the aging brain.

    Jeffrey N. Keller;Edgardo Dimayuga;Qinghua Chen;Jeffrey Thorpe

  • High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling

    Christopher D. Morrison;Paul J. Pistell;Donald K. Ingram;William D. Johnson

  • Effects of high fat diet on Morris maze performance, oxidative stress, and inflammation in rats: contributions of maternal diet.

    Christy L. White;Paul J. Pistell;Megan N. Purpera;Sunita Gupta

  • Increased sensitivity to mitochondrial toxin-induced apoptosis in neural cells expressing mutant presenilin-1 is linked to perturbed calcium homeostasis and enhanced oxyradical production.

    Jeffrey N. Keller;Qing Guo;F. W. Holtsberg;A. J. Bruce-Keller

Frequent Co-Authors

William R. Markesbery
William R. Markesbery University of Kentucky
Mark P. Mattson
Mark P. Mattson Johns Hopkins University
Rong Zhang
Rong Zhang The University of Texas Southwestern Medical Center
Harry LeVine
Harry LeVine University of Kentucky
Mark S. Kindy
Mark S. Kindy University of South Florida
Donald K. Ingram
Donald K. Ingram Louisiana State University
D. Allan Butterfield
D. Allan Butterfield University of Kentucky
Catrine Tudor-Locke
Catrine Tudor-Locke University of North Carolina at Charlotte
Stephen W. Scheff
Stephen W. Scheff University of Kentucky
Owen Carmichael
Owen Carmichael Pennington Biomedical Research Center

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Related Online Degrees & Career Pathways

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