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Biology and Biochemistry

D-Index
72
Citations
18402
World Ranking
6306
National Ranking
408

Overview

Keiji Miyazawa is affiliated with the University of Yamanashi in Japan. The primary research focus lies in the fields of Biochemistry, Genetics and Molecular Biology, with an emphasis on Medicine. Subfields include Molecular Biology, Oncology, Cancer Research, Cell Biology, and Pathology and Forensic Medicine.

The main research topics covered in their work are:

  • TGF-β signaling in diseases
  • Cancer Cells and Metastasis
  • Cancer-related gene regulation
  • Renal and related cancers
  • Cancer, Hypoxia, and Metabolism
  • Chemokine receptors and signaling
  • Wnt/β-catenin signaling in development and cancer

Frequent publication venues for Keiji Miyazawa's research include:

  • Journal of Biological Chemistry
  • Cancer Science
  • The Journal of Biochemistry
  • Oncogenesis
  • FEBS Open Bio

Some recent papers authored by or associated with Keiji Miyazawa are:

  • Receptor-activated transcription factors and beyond: multiple modes of Smad2/3-dependent transmission of TGF-β signaling, 2024, Journal of Biological Chemistry
  • EHF suppresses cancer progression by inhibiting ETS1-mediated ZEB expression, 2021, Oncogenesis
  • Dissociation of the AhR/ARNT complex by TGF-β/Smad signaling represses CYP1A1 gene expression and inhibits benze[a]pyrene-mediated cytotoxicity, 2020, Journal of Biological Chemistry
  • Neurotensin receptor 1 signaling promotes pancreatic cancer progression, 2020, Molecular Oncology
  • Ets family proteins regulate the EMT transcription factors Snail and ZEB in cancer cells, 2022, FEBS Open Bio

Frequent collaborators in their research include:

  • Masao Saitoh
  • Yuka Itoh
  • Chiho Omata
  • Kohei Miyazono
  • Takashi Yokoyama

Best Publications

  • Two major Smad pathways in TGF-beta superfamily signalling.

    Keiji Miyazawa;Masahiko Shinozaki;Takane Hara;Toshio Furuya

  • Molecular cloning and sequence analysis of cDNA for human hepatocyte growth factor

    Keiji Miyazawa;Hirohito Tsubouchi;Daiji Naka;Kazuhiro Takahashi

  • Autocrine TGF-β Signaling Maintains Tumorigenicity of Glioma-Initiating Cells through Sry-Related HMG-Box Factors

    Hiroaki Ikushima;Tomoki Todo;Yasushi Ino;Masamichi Takahashi

  • Tyrosine Phosphorylation of β-Catenin and Plakoglobin Enhanced by Hepatocyte Growth Factor and Epidermal Growth Factor in Human Carcinoma Cells

    S Shibamoto;M Hayakawa;K Takeuchi;T Hori

  • Molecular cloning and sequence analysis of the cDNA for a human serine protease reponsible for activation of hepatocyte growth factor. Structural similarity of the protease precursor to blood coagulation factor XII.

    K. Miyazawa;T. Shimomura;A. Kitamura;J. Kondo

  • Regulation of TGF-β Family Signaling by Inhibitory Smads.

    Keiji Miyazawa;Kohei Miyazono

  • Association of p120, a Tyrosine Kinase Substrate, With E-cadherin/catenin Complexes

    S Shibamoto;M Hayakawa;K Takeuchi;T Hori

  • VEGF-A and FGF-2 synergistically promote neoangiogenesis through enhancement of endogenous PDGF-B–PDGFRβ signaling

    Mitsunobu R. Kano;Yasuyuki Morishita;Caname Iwata;Shigeru Iwasaka

  • Hepatocyte Growth Factor Activator Inhibitor, a Novel Kunitz-type Serine Protease Inhibitor *

    Takeshi Shimomura;Kimitoshi Denda;Akiko Kitamura;Toshiya Kawaguchi

  • Regulation of Interleukin-1β-induced Interleukin-6 Gene Expression in Human Fibroblast-like Synoviocytes by p38 Mitogen-activated Protein Kinase

    Keiji Miyazawa;Akio Mori;Hiroshi Miyata;Masuo Akahane

  • NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-β (transforming growth factor-β) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-β type I receptor

    Go Kuratomi;Akiyoshi Komuro;Kouichiro Goto;Kouichiro Goto;Masahiko Shinozaki

  • Arkadia amplifies TGF-β superfamily signalling through degradation of Smad7

    Daizo Koinuma;Daizo Koinuma;Masahiko Shinozaki;Akiyoshi Komuro;Kouichiro Goto;Kouichiro Goto

  • Id: a target of BMP signaling.

    Kohei Miyazono;Keiji Miyazawa

  • A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP.

    Masaki Kato;Keiji Miyazawa;Naomi Kitamura

  • Activation of hepatocyte growth factor by proteolytic conversion of a single chain form to a heterodimer.

    D Naka;T Ishii;Y Yoshiyama;K Miyazawa

  • Proteolytic activation of hepatocyte growth factor in response to tissue injury.

    K Miyazawa;T Shimomura;D Naka;N Kitamura

  • TGF-β regulates isoform switching of FGF receptors and epithelial–mesenchymal transition

    Takuya Shirakihara;Kana Horiguchi;Keiji Miyazawa;Shogo Ehata

  • Targets of transcriptional regulation by two distinct type I receptors for transforming growth factor-beta in human umbilical vein endothelial cells.

    Tatsuru Ota;Makiko Fujii;Takashi Sugizaki;Masami Ishii

  • Activation of Hepatocyte Growth Factor in the Injured Tissues Is Mediated by Hepatocyte Growth Factor Activator

    Keiji Miyazawa;Takeshi Shimomura;Naomi Kitamura;Naomi Kitamura

  • Chromatin Immunoprecipitation on Microarray Analysis of Smad2/3 Binding Sites Reveals Roles of ETS1 and TFAP2A in Transforming Growth Factor β Signaling

    Daizo Koinuma;Shuichi Tsutsumi;Naoko Kamimura;Hirokazu Taniguchi

Frequent Co-Authors

Kohei Miyazono
Kohei Miyazono University of Tokyo
Naomi Kitamura
Naomi Kitamura Tokyo Institute of Technology
Takeshi Imamura
Takeshi Imamura Ehime University
Tetsuro Watabe
Tetsuro Watabe Tokyo Medical and Dental University
Hiroaki Kataoka
Hiroaki Kataoka University of Miyazaki
Hiroyuki Aburatani
Hiroyuki Aburatani University of Tokyo
Akio Mori
Akio Mori University of Tokyo
Yasuyuki Morishita
Yasuyuki Morishita University of Tokyo
Hiroshi Itoh
Hiroshi Itoh Yamaguchi University
Masahiko Kuroda
Masahiko Kuroda Tokyo Medical University

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