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Molecular Biology
Italy
2026
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Genetics and Molecular Biology
Italy
2024

D-Index & Metrics

Molecular Biology

D-Index
132
Citations
59546
World Ranking
176
National Ranking
2

Research.com Recognitions

  • 2026 - Research.com Molecular Biology in Italy Leader Award
  • 2025 - Research.com Molecular Biology in Italy Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in Italy Leader Award
  • 2023 - Research.com Genetics and Molecular Biology in Italy Leader Award
  • 2023 - Research.com Molecular Biology in Italy Leader Award
  • 2022 - Research.com Genetics and Molecular Biology in Italy Leader Award
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Paolo M. Comoglio is affiliated with the University of Turin in Italy. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with a significant focus on Medicine. Comoglio's work further specializes in subfields such as Molecular Biology, Oncology, Hepatology, Cancer Research, and Pathology and Forensic Medicine.

The scientist's main research topics include:

  • Liver physiology and pathology
  • PI3K/AKT/mTOR signaling in cancer
  • Cancer Diagnosis and Treatment
  • Tumors and Oncological Cases
  • Oral and Maxillofacial Pathology
  • Cancer, Hypoxia, and Metabolism
  • Cancer Cells and Metastasis

Comoglio has contributed to several recent publications, exemplifying a focus on cancer biology, signaling pathways, and therapeutic vulnerabilities. Selected recent papers include:

  • Cancer of unknown primary stem-like cells model multi-organ metastasis and unveil liability to MEK inhibition (2021), Nature Communications
  • ERBB3 overexpression due to miR-205 inactivation confers sensitivity to FGF, metabolic activation, and liability to ERBB3 targeting in glioblastoma (2021), Cell Reports
  • Activation of the MET receptor attenuates doxorubicin-induced cardiotoxicity in vivo and in vitro (2020), British Journal of Pharmacology
  • Real-world histopathological approach to malignancy of undefined primary origin (MUO) to diagnose cancers of unknown primary (CUPs) (2022), Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin
  • hOA-DN30: a highly effective humanized single-arm MET antibody inducing remission of 'MET-addicted' cancers (2022), Journal of Experimental & Clinical Cancer Research

Frequent co-authors collaborating with Comoglio include:

  • Carla Boccaccio
  • Federica Verginelli
  • Alberto Pisacane
  • Gennaro Gambardella
  • Antonio D'Ambrosio

Comoglio's work is often published in notable scientific venues, with multiple publications in the following journals:

  • Cell Reports
  • Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin
  • Journal of Experimental & Clinical Cancer Research
  • EMBO Molecular Medicine
  • Cancer Research

Among distinctions, Paolo M. Comoglio has been recognized as a Member of the European Molecular Biology Organization (EMBO).

Best Publications

  • Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth

    F Bussolino;M F Di Renzo;M Ziche;E Bocchietto

  • Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene.

    Selma Pennacchietti;Paolo Michieli;Maria Galluzzo;Massimiliano Mazzone

  • Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.

    Luca Tamagnone;Stefania Artigiani;Hang Chen;Zhigang He

  • MET signalling: principles and functions in development, organ regeneration and cancer.

    Livio Trusolino;Andrea Bertotti;Paolo M. Comoglio

  • A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family

    Carola Ponzetto;Alberto Bardelli;Alberto Bardelli;Zhu Zhen;Flavio Maina

  • Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (HERACLES): A proof-of-concept, multicentre, open-label, phase 2 trial

    Andrea Sartore-Bianchi;Livio Trusolino;Cosimo Martino;Katia Bencardino

  • A molecularly annotated platform of patient-derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer.

    Andrea Bertotti;Giorgia Migliardi;Francesco Galimi;Francesco Sassi

  • Drug development of MET inhibitors : targeting oncogene addiction and expedience

    Paolo M. Comoglio;Silvia Giordano;Livio Trusolino

  • Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-MET.

    L Naldini;E Vigna;R P Narsimhan;G Gaudino

  • Scatter-factor and semaphorin receptors: cell signalling for invasive growth

    Livio Trusolino;Paolo M. Comoglio

  • Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor.

    L. Naldini;K.M. Weidner;E. Vigna;G. Gaudino

  • Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor.

    Luigi Naldini;Luca Tamagnone;Elisa Vigna;Martin Sachs

  • Invasive growth: a MET-driven genetic programme for cancer and stem cells

    Carla Boccaccio;Paolo M. Comoglio

  • Regulation of scatter factor/hepatocyte growth factor responses by Ras, Rac, and Rho in MDCK cells.

    A J Ridley;P M Comoglio;A Hall

  • Induction of epithelial tubules by growth factor HGF depends on the STAT pathway

    Carla Boccaccio;Margherita Andò;Luca Tamagnone;Alberto Bardelli

  • Amplification of the MET Receptor Drives Resistance to Anti-EGFR Therapies in Colorectal Cancer

    Alberto Bardelli;Simona Corso;Andrea Bertotti;Sebastijan Hobor

  • Expression of the Met/HGF receptor in normal and neoplastic human tissues.

    M. F. Di Renzo;R. P. Narsimhan;M. Olivero;S. Bretti

  • Tyrosine kinase receptor indistinguishable from the c-met protein.

    S. Giordano;C. Ponzetto;M. F. Di Renzo;C. S. Cooper

  • A Signaling Adapter Function for α6β4 Integrin in the Control of HGF-Dependent Invasive Growth

    Livio Trusolino;Andrea Bertotti;Paolo M Comoglio

  • Plexin A Is a Neuronal Semaphorin Receptor that Controls Axon Guidance

    Margaret L Winberg;Jasprina N Noordermeer;Luca Tamagnone;Paolo M Comoglio

Frequent Co-Authors

Silvia Giordano
Silvia Giordano University of Turin
Alberto Bardelli
Alberto Bardelli University of Turin
Enzo Medico
Enzo Medico University of Turin
Luigi Naldini
Luigi Naldini Vita-Salute San Raffaele University
Luca Tamagnone
Luca Tamagnone Catholic University of the Sacred Heart
Giovanni Gaudino
Giovanni Gaudino University of Hawaii at Manoa
Guido Tarone
Guido Tarone University of Turin
Filippo G. Giancotti
Filippo G. Giancotti Columbia University
Pier Carlo Marchisio
Pier Carlo Marchisio Vita-Salute San Raffaele University

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